Fetal Origins of Adult Disease

Chairperson: John Rogers, U.S. Environmental Protection Agency

Speaker: Laura A. Cox, Southwest Foundation for Biomedical Research

Chairpersons: Jerry J. Heindel, National Institute of Environmental Health Sciences and Claudia Kappen, Pennington Biomedical Research Center

9:00 AM – 9:05 AM

Introduction

9:05 AM – 9:40 AM

Prevalence of Maternal Obesity and Pregnancy Complications

Speakers: Sonja A Rasmussen, Center for Disease Control and Prevention

9:40 AM – 10:15 AM

The Nutritional Environment during the Suckling Period Determines the Capacity for Adipose Tissue Expansion in Adult Mice

Speaker: Leslie P. Kozak, Pennington Biomedical Research Center

10:15 AM – 10:30 AM

Break

10:30 AM – 11:05 AM

Developmental Epigenetics of the Hypothalamus

Speaker: Robert A. Waterland, Baylor College of Medicine

11:05 AM – 11:40 AM

Management of the Obese Gravida: Present and Future

Speaker: Brian J. Koos, David Geffen School of Medicine at UCLA

11:40 AM – 11:45 AM

Conclusions

Chairpersons: Stanley Barone, Jr., U.S. Environmental Protection Agency and Carmen Umpierre, University of Puerto Rico, Cayey

1:15 PM–1:30 PM

Overview of Vulnerability to Environmental Chemical Exposures

Barone, Jr. S. U.S. Environmental Protection Agency, Washington, DC, United States.

1:30 PM–1:45 PM

Quantitative Analysis of Early Childhood Floor Behavior and Inhalation Exposure to Toxins

Shalot S^1,2, Hernandez M², Black K². ¹Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, United States, ²Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway, NJ, United States.

1:45 PM–2:00 PM

Prenatal Exposure to Environmental Contaminants is Related to Sub-Clinical Behavioral Impairment in Inuit Children in Arctic Quebec

Plusquellec P^1,2, Muckle G^1,2, Dewailly E^1,3, Ayotte P^1,3. ¹Public Health Research Unit, CHUQ Research Center (CHUL), Quebec City, QC, Canada, ²School of Psychology, Laval University, Quebec City, QC, Canada, ³Department of Social and Preventive Medicine, Laval University, Quebec City, QC, Canada.

2:00 PM–2:15 PM

Differential Neurobehavioral Responses in PCB-Treated Mice Having Different Ahr and Cyp1a2 Alleles

Curran C^1,2, Patel K², Willilams M³, Vorhees C³, Nebert D². ¹Northern Kentucky University, Highland Heights, KY, United States. ²University of Cincinnati, College of Medicine, Cincinnati, OH, United States, ³Cincinnati Children’s Resarch Foundation, Cincinnati, OH, United States.

2:15 PM–2:30 PM

AhR-Mediated Gene Expression in the Developing Mouse Telencephalon

Gohlke JM¹, Stockton P², Sieber S³, Foley J², Portier CJ¹. ¹Environmental Systems Biology Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States, ²Laboratory of Environmental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States, ³Microarray Group, Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, NC, United States.

2:30 PM–2:45 PM

Exposure to Pyrethroid Insecticides Alters Expression of Genes Important for Dopaminergic Neuronal Development

Demicco A¹, Richardson J², Cooper K¹, White L¹. ¹Rutgers University, New Brunswick, NJ, United States, ²University of Medicine and Dentistry of New Jersey, Piscataway, NJ, United States.

2:45 PM–3:00 PM

Profiling Developmental Toxicity of 387 Environmental Chemicals Using EPA’s Toxicity Reference Database (ToxRefDB)

Knudsen TB¹, Martin MT¹, Kavlock RJ¹, Judson RS¹, Dix DJ¹, Singh AV². ¹NCCT, U.S. EPA, Research Triangle Park, NC, United States, ²Lockheed Martin, Research Triangle Park, NC, United States.

3:00 PM–3:15 PM

Scientific Consensus Statement on Environmental Agents Associated with Neurodevelopmental Disorders

1:15 PM–1:30 PM

Exposure to Herbal Products during Pregnancy and the Risk of Low Birth Weight

Moussally KM^1,2, Koren GK³, Berard AB^1,2. ¹Faculty of Pharmacy, University of Montreal, Montreal, QC, Canada, ²Research Center, CHU Sainte-Justine, Montreal, QC, Canada, ³Motherisk Program, Hospital for Sick Children, Toronto, ON, Canada.

1:30 PM–1:45 PM

Maternal Nutrition and Risk for Gastroschisis: Findings from the National Birth Defects Prevention Study

Feldkamp ML^1,2, Stone MB^1,2, Carmichael SL³, Shaw GM^3,4, Moore CA⁵, Botto LD^1,2. ¹Dept. of Pediatrics, University of Utah, Salt Lake City, UT, United States, ²Utah Birth Defect Network, Salt Lake City, UT, United States, ³March of Dimes Research Division, Children’s Hospital Oakland Research Institute, Oakland, CA, United States, ⁴Dept. of Pediatrics, Stanford University, Palo Alto, CA, United States, ⁵NCBDDD, Centers for Disease Control and Prevention, Atlanta, GA, United States.

1:45 PM–2:00 PM

Gestational Diet Influences Neonatal Osteogenesis and Adult Skeletal Structure

Prater MR^1,2, Liang C². ¹Edward Via VA College of Osteopathic Medicine, Blacksburg, VA, United States, ²VA-MD Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.

2:00 PM–2:15 PM

Characterization of Teratogen Present in Tap Water

Mallela MK¹, Przybyla J¹, Etzkorn FA¹, Blodgett DJ¹, Hrubec TC^1,2. ¹Virginia Polytechnic Institute and State University, Blacksburg, VA, United States, ²E. Via Virginia College of Osteopathic Medicine, Blacksburg, VA, United States.

2:15 PM–2:30 PM

Altered Nutrient Status in Alcohol-Exposed Women during Mid-Gestation

Uriu-Adams JY¹, Gross HB¹, Chambers CD², Ensunsa JL¹, Green K¹, Yevtushok L³, Wertelecki WW⁴, Keen CL¹. ¹University of California, Davis, Davis, CA, United States, ²University of California, San Diego, San Diego, CA, United States, ³Rivne Diagnostic Center, Rivne, Ukraine, ⁴University of South Alabama, Mobile, AL, United States.

2:30 PM–2:45 PM

Docosahexanoic Acid: A Potential Protector against the Developmental Effects of Prenatal Alcohol Exposure

Fraser SL^1,2, Muckle G^1,2, Jacobson J³, Jacobson SW³. ¹School of Psychology, Laval University, Quebec, QC, Canada, ²Centre de Recherche du Centre Hospitalier Universitaire de Québec, Québec, QC, Canada, ³Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI, United States.

2:45 PM–3:00 PM

Implications of Altered Gene Expression in Embryo and Placenta during Diabetic Pregnancy

Kappen C¹, Pavlinkova G², Kruger C¹, Salbaum JM¹. ¹Pennington Biomedical Research Center, Baton Rouge, LA, United States, ²Academy of Sciences of the Czech Republic, Prague, Czech Republic.

3:00 PM–3:15 PM

Lipid Mediators Link Cell Cycle Progression with Placental and Neural Tube Defects after Maternal Fumonisin or FTY720

Chairpersons: Christina D. Chambers, University of California, San Diego and Christopher J. Stodgell, University of Rochester School of Medicine & Dentistry

3:30 PM – 3:35 PM

Introduction

3:35 PM – 4:00 PM

Overview of the Epidemiology of Autism Spectrum Disorder and Approaches to Finding Its Causes

Speaker: Craig J. Newschaffer, Drexel University School of Public Health

4:00 PM – 4:25 PM

The Autisms: Disorders of the Developing Brain with Public Health Implications

Speaker: Edwin Trevathan, National Center on Birth Defects & Developmental Disabilities, CDC

4:25 PM – 4:50 PM

"Pregnancy/Birth” and “Baby Sib” Studies of Autism Spectrum Disorders

Speaker: Ezra S. Susser, Columbia University

4:50 PM – 5:15 PM

Genetic and Environmental Risk Factors for Autism Spectrum Disorders

Speaker: Christopher J. Stodgell, University of Rochester School of Medicine & Dentistry

5:15 PM – 5:30 PM

Question/Answer – Panel Discussion