Clinical Teratology: In Bed with the Devil?

Speaker: Jan M. Friedman, University of British Columbia

9:15 AM–9:30 AM

Introduction

9:30 AM–9:45 AM

Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) As a Target for Teratogen-Induced Oxidative Stress During Organogenesis

Schlisser AE, Hales BF. McGill University, Montreal, QC, Canada.

9:45 AM–10:00 AM

Tissue Drug Concentrations, Oxidative DNA Damage and Embryopathies in Acatalasemic and Catalase-Overexpressing Embryos Exposed In Utero to Phenytoin

Perstin J¹, Wells PG¹,². ¹Department of Pharmaceutical Sciences, University of Toronto, Toronto, ON, Canada, ²Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

10:00 AM–10:15 AM

Effects of Trichloroethylene on Heart Development

Makwana O, King NMP, Ahles L, Granzier H, Selmin O, Runyan RB. University of Arizona, Tucson, AZ, United States.

10:15 AM–10:30 AM

Ethanol Embryopathies, Oxidative Stress and Protection by a Free Radical Spin Trapping Agent

Miller L¹, Wells PG². ¹Dept. of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada, ²Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

10:45 AM–11:00 AM

Resistance of CD-1 Mouse Embryos in Culture and DNA Repair-Deficient Ogg-1 Knockout Mice In Vivo to the Embryopathic Effects of Thalidomide or Its Hydrolysis Products

Lee CJJ¹, Wiley MJ², Wells PG¹,³. ¹Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada, ²Dept. of Surgery, University of Toronto, Toronto, ON, Canada, ³Dept. of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.

11:00 AM–11:15 AM

A Large-Scale In Situ Hybridization Assay for Transcription-Regulating Genes: A Mouse Embryo Gene Expression Database

Shimizu H^1,2, Yokoyama S^1,3, Hashimoto M¹, Uchibe K^1,4, Kiso M¹, Asahara H^1,5. ¹The National Research Institute for Child Health and Development, Setagaya, Tokyo, Japan, ²University of California, Los Angeles, Los Angeles, CA, United States, ³Waseda University, Tokorozawa, Saitama, Japan, ⁴Okayama University, Okayama, Japan, ⁵The Scripps Research Institute, La Jolla, CA, United States.

11:15 AM–11:30 AM

Nanoparticles and the Maternal-Retal Barrier: Do They Cross?

Rinderknecht A¹, Oberdorster G¹, de Mesy Bentley K², Gelein R¹, Elder A¹, Brewer K³, Miller R^1,3. ¹University of Rochester, Department of Environmental Medicine, Rochester, NY, United States, ²University of Rochester, Department of Pathology, Rochester, NY, United States, ³University of Rochester, Department of Obstetrics and Gynecology, Rochester, NY, United States.

11:30 AM–11:45 AM

Role of Nitrite in Glyceryl Trinitrate (GTN) Induced Microphthalmia in Quail Embryos

Bardai GK^1,2, Sunahara GI², Hales BF¹. ¹McGill University, Montreal, QC, Canada, ²National Research Council of Canada, Montreal, QC, Canada.

11:45 AM–12:00 NOON

Valproic Acid Alters the Expression of Hdac1 and Hif1a in Murine Limb Buds

Paradis FH, Hales BF. McGill University, Montreal, QC, Canada.

Brent Lecture: Use of Natural Products During Pregnancy

Chairperson: Janee Van Waes, University of Nebraska

Speaker: Gideon Koren, Hospital for Sick Children

(European Teratology Society and Teratology Society Exchange)

Chairperson: Jochen Buschmann, Fraunhofer

European Teratology Society Speaker: Luc de Schaepdrijver, Janssen Pharmaceutica, Johnson and Johnson

Teratology Society Speaker: Melissa Tassinari, Pfizer Inc.

Prematurity: A Clinical Dilemma

Chairpersons: Michael Katz, March of Dimes and Jose Cordero, University of Puerto Rico Graduate School of Public Health

3:30 PM – 3:40 PM

Introduction

Speaker: Michael Katz, March of Dimes

3:40 PM – 4:15 PM

Global Prevalence and Opportunities for Intervention in Middle- and Low-Income Countries

Speaker: Christopher P. Howson, March of Dimes

4:15 PM – 4:25 PM

Risk for Increase in Preterm Births in Puerto Rico: Not the Usual Suspects

Speaker: Jose F. Cordero, University of Puerto Rico Graduate School of Public Health

4:25 PM – 4:55 PM

The Role of Infection and Inflammation in Preterm Labor and Fetal Injury

Speaker: Roberto Romero, National Institute of Child Health and Human Development

4:55 PM – 5:25 PM

Genetic and Genomic Analysis of Preterm Birth

Speaker: Louis J. Muglia, Vanderbilt University Medical Center

5:25 PM – 5:55 PM

Pre-Term Labor: Signals and Mechanisms Revealed in Animal Models

Speaker: Stephen J. Lye, Samuel Lunenfield Research Institute

5:55 PM – 6:00 PM

Conclusions