TS 2010 Annual Meeting

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Meeting Program

(information subject to change)

Sunday, June 27, 2010

8:00 AM–7:00 PM	Registration—Marriott Ballroom VI Foyer

8:00 AM–8:15 AM	President’s Welcome—Marriott Ballroom VI

8:15 AM–9:15 AM	Josef Warkany Lecture—Marriott Ballroom VI
	50 Years of Progress in Understanding the Causes of Three Common Birth Defects
	Diana M. Juriloff, University of British Columbia

9:15 AM–11:45 AM	Student/Postdoctoral Fellow Platform Session 1—Marriott Ballroom VI Wilson Presentation Award Competition Organized by the Student Affairs Committee

9:15 AM–9:30 AM	Introduction

9:30 AM–9:45 AM	Exposure of Organogenesis Stage Mouse Embryos to Hydroxyurea Induces Nuclear 4-hydroxy-2-nonenal Protein Adducts
	Schlisser AE, Hales BF. McGill University, Montreal, QC, Canada.

9:45 AM–10:00 AM	Maternal DNA Hypomethylation, Methionine Pathway Metabolites, Lifestyle Factors and Congenital Heart Defects
	Chowdhury S, Cleves MA, MacLeod SL, Zhao W, Hobbs CA. University of Arkansas for Medical Sciences, Arkansas Children’s Hospital Research Institute, Little Rock, AR, United States.

10:00 AM–10:15 AM	A Toxicity Signature for Species-Specific Disruption of Embryonic Vasculogenesis Derived from ToxCast™ In Vitro Profiling Data
	Kleinstreuer N¹, Dix D¹, Judson R¹, Kavlock R¹, Sipes N¹, Reif D¹, Chandler K^1,3, Rountree M¹, DeWoskin R², Singh A⁴, Spencer R⁴, Knudsen T¹. ¹NCCT, ORD, U.S. EPA, Research Triangle Park, NC, United States, ²NCEA, ORD, U.S. EPA, Research Triangle Park, NC, United States, ³NHEERL, ORD, U.S. EPA, Research Triangle Park, NC, United States, ⁴Lockheed Martin, Research Triangle Park, NC, United States.

10:15 AM–10:30 AM	Exposure to 2-methoxyacetic Acid Induces Limb Malformations and Histone 4 Hyperacetylation In Vitro
	Dayan C, Hales BF. McGill University, Montreal, QC, Canada.

10:30 AM–10:45 AM	Break

10:45 AM–11:00 AM	High-Throughput Screening of ToxCast™ Phase I Chemicals in an Embryonic Stem Cell Assay Reveals Potential Disruption of a Critical Developmental Signaling Pathway
	Chandler K^1,2, Hunter S¹, Jeffay S¹, Nichols H¹, Hoopes M¹, Barrier M¹, Habig J³, Knudsen T². ¹Integrated Systems Toxicology Division, U.S. EPA, Research Triangle Park, NC, United States, ²National Center for Computational Toxicology, U.S. EPA, Research Triangle Park, NC, United States, ³Endogenics, Eagle, ID, United States

11:00 AM–11:15 AM	Valproic Acid Disrupts Chondrocyte Differentiation and Increases Apoptosis In Vitro in Murine Limb Buds
	Paradis FH, Hales BF. McGill University, Montreal, QC, Canada.

11:15 AM–11:30 AM	Dissecting the Action of Bisphenol-A on Germline Maintenance Using C. elegans
	Allard P, Colaiacovo M. Harvard Medical School, Genetics, Boston, MA, United States.

11:30 AM–11:45 AM	Transfer of Dendrimers in the Perfused Human Placental Lobule In Vitro: Prospects for Use As Drug Carriers during Pregnancy
	Rinderknecht AL¹, Menjoge AR^2,3, Kannan RM^2,3, Kim CJ³, Romero R³, Faridnia M¹, Miller RK¹. ¹University of Rochester, Rochester, NY, United States, ²Wayne State University, Detroit, MI, United States, ³National Institute of Child Health and Human Development, Detroit, MI, United States.

11:45 AM–12:00 NOON	Box Lunch Pick up—Marriott Ballroom VI

12:00 NOON–1:00 PM	TS/OTIS Robert L. Brent Lecture (A Box Lunch Session)—Marriott Ballroom VI
	Ionizing Radiation Exposure to the Fetus and Infant from Medical Imaging: A Radiologist’s Perspective
	Donald P. Frush, Duke University Medical Center

1:00 PM–1:30 PM	F. Clarke Fraser Award—Marriott Ballroom VI
	Gastroschisis: A Journey to Discover the Pieces of the Puzzle
	Marcia L. Feldkamp, University of Utah

1:30 PM–2:00 PM	James G. Wilson Publication Award—Marriott Ballroom VI
	Regulation of Folate Receptor 1 Gene Expression in the Visceral Endoderm
	J. Michael Salbaum, Pennington Biomedical Research Center

2:00 PM–3:00 PM	TS/ETS Joint Exchange Lecture —Marriott Ballroom VI Pros and Cons of the Extended One-Generation Study Protocol
	Teratology Society The Cons of the Extended One-Generation Study Protocol Paul M.D. Foster, National Institute of Environmental Health Sciences
	European Teratology Society The Extended One-Generation Reproduction Toxicity Study: Improving Hazard Assessment and Saving Animals? Aldert H. Piersma, National Institute for Public Health and the Environment (RIVM), Bilthoven

3:00 PM–3:15 PM	Break

3:15 PM–5:45 PM	Vitamin B₁₂ and Neural Tube Defects: Is It Time to Fortify Food with B₁₂ Symposium—Marriott Ballroom VI
	Chairperson: James L. Mills, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH

3:15 PM–3:40 PM	Vitamin B₁₂ Deficiency and NTDs: Is There a Causal Relationship?
	James L. Mills, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH

3:40 PM–4:05 PM	Normal Vitamin B₁₂ Physiology, the Pathophysiology of B₁₂ Deficiency, and Their Relevance to Treatment and Fortification
	Ralph Carmel, New York Methodist Hospital and Weill Medical College of Cornell University

4:05 PM–4:30 PM	Should FDA Require Vitamin B₁₂ Fortification of Enriched Flour? Yes
	Godfrey P. Oakley, Emory University

4:30 PM–4:55 PM	Should We Fortify Food with B₁₂ Now? No
	Ralph Green, University of California Davis Medical Center

4:55 PM–5:45 PM	Panel Discussion and Response to Questions from the Audience

6:00 PM–8:00 PM	Joint TS/NBTS Welcome Reception and Exhibits Open —Marriott Ballroom I Silent Auction