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Annual Meeting 2015

Meeting Program

(Information is subject to change.)

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Monday, June 29, 2015

 

 

7:00 AM–6:00 PM REGISTRATION OPEN – Registration Desk
   
7:00 AM–6:00 PM SPEAKER READY ROOM OPEN – St. Lambert
   
7:00 AM–8:00 AM 2016 PROGRAM COMMITTEE MEETING – St. Pierre
   
8:00 AM–9:00 AM REMEMBERING F. CLARKE FRASER – Westmount
  Chairperson: Richard H. Finnell, The University of Texas and Michel Vekemans, Hopital Necker-Enfants Malades
8:00 AM–8:08 AM Introduction
  Patrick McLeod, University of Victoria
   
8:08 AM–8:21 AM Oral Clefts
  Diana M. Juriloff, University of British Columbia
   
8:21 AM–8:34 AM Spectrum of Anomalies in the Meckel Syndrome: An Update
  Michel Vekemans, Hopital Necker-Enfants Malades
   
8:34 AM–8:47 AM Birth Defects, Imprinting, and Intergenerational Effects
  Jacquetta M. Trasler, McGill University
   
8:47 AM–9:00 AM Strain Differences in Susceptibility to Teratogen-Induced Neural Tube Defects
  Richard H. Finnell, The University of Texas
   
9:00 AM–12:00 Noon WILEY-BLACKWELL SYMPOSIUM – Westmount
Are Human Skeletal Malformations the Result of Embryonic Arterial Dysgenesis?
  Chairpersons: Lewis B. Holmes, MassGeneral Hospital for Children and David R. Hootnick, SUNY Upstate Medical University
9:00 AM–9:05 AM   Introduction
     
9:05 AM–9:45 AM S5 Embryonic Arterial Dysgenesis and Long Bone Deficiencies
    David R. Hootnick, SUNY Upstate Medical University
     
9:45 AM–10:25 AM S6 Anatomical Inferences Regarding Gestational Stage and Location of Teratogenic Events are Informed by Dissection of Malformed Human Limbs
    John M. DeSesso, Exponent
     
10:25 AM–10:40 AM   Break — Fontaine B
     
10:40 AM–11:00 AM   Discussion
     
11:00 AM–11:45 AM S8 Thalidomide-Induced Teratogenesis: Lessons and Insights Into Abnormal Development
    Neil Vargesson, University of Aberdeen
     
11:45 AM–12:00 Noon   Discussion
   
9:00 AM–12:00 Noon

REGULATORY NEURODEVELOPMENTAL TESTING: NEW GUIDING PRINCIPLES FOR HARMONIZATION OF DATA COLLECTION AND ANALYSIS WORKSHOP – Outremont
(Joint with NBTS)

  Chairpersons: Alan M. Hoberman, Charles River and Abby A. Li, Exponent Inc.
9:00 AM–9:10 AM W2 Reexamining the Developmental Neurotoxicity Study and Risk Assessment
    Francis Bailey, Health Canada Pest Management Regulatory Agency
     
9:10 AM–9:35 AM W3 Evaluating Data Variability for Neurobehavioral Measure: How Much is too Much?
    Larry P. Sheets, Bayer CropScience
     
9:35 AM–9:55 AM W4 New Insights into Analysis of Highly Variable Data: Motor Activity As a Case Study
    Wayne Bowers, Health Canada and Carleton University
     
9:55 AM–10:20 AM W5 Hypothesis-Driven Testing and Analysis: Auditory Startle As a Case Study
    Kathleen Raffaele, Office of Solid Waste and Emergency Response, US EPA
     
10:20 AM–10:35 AM   Break — Fontaine B
     
10:35 AM–11:00 AM W6 Standardization of SOPs to Evaluations: Impacts on Regulatory Decisions Using Learning and Memory as Case Studies
    Virginia C. Moser, Office of Research and Development, US EPA
     
11:00 AM–11:25 AM W7 Weight of Evidence (WOE) and Benchmark Dose (BMD) Analysis: Brain Morphometry and Startle Behavior As Examples
    Abby A. Li, Exponent Inc.
     
11:25 AM–12:00 Noon   Discussion
    Francis Bailey, Health Canada Pest Management Regulatory Agency; Alan M. Hoberman, Charles River; Angela Hofstra, Syngenta Canada; and Susan L. Makris, US Environmental Protection Agency

 

 

12:00 Noon–1:30 PM

LUNCH ON YOUR OWN

   
12:00 PM–1:30 PM BDRA EDITORIAL BOARD MEETING—St. Pierre
   

12:00 Noon–1:30 PM

PAST PRESIDENT'S AND HONOREES' LUNCHEON (By Invitation Only) – Fontaine H

   
1:30 PM–5:30 PM

MARCH OF DIMES SYMPOSIUM – Westmount
Perinatal Outcomes Following Assisted Reproductive Technologies (Joint with OTIS)

  Chairpersons: Kembra L. Howdeshell, National Institute of Environmental Health Sciences and Laxmi Kondapalli, Colorado Center for Reproductive Medicine
1:30 PM–1:35 PM   Introduction
    Kembra L. Howdeshell, National Institute of Environmental Health Sciences
     
1:35 PM–2:10 PM S9 The Occurrence of Birth Defects in Relation to Assisted Reproductive Technologies in the Massachusetts Outcomes Study of Assisted Reproductive Technology (MOSART) Database
   

Kelly D. Getz, The Children's Hospital of Philadelphia

     
2:10 PM–2:50 PM S10 The Impact of Multiple Gestations on IVF Outcomes
    Barbara Luke, Michigan State University
     
2:50 PM–3:30 PM S11 Assisted Reproduction and Changes in the Epigenome
    Winifred Mak, Yale University
     
3:30 PM–3:45 PM   Break — Fontaine B
     
3:45 PM–4:25 PM S12 Prospective Cohort Study of Autism, Neurodevelopment, and Behavior in Young Children Conceived by Assisted Reproductive Technology (ART): Cause for Concern or Reassurance?
    Laxmi A. Kondapalli, Colorado Center for Reproductive Medicine
     
4:25 PM–5:05 PM S13 States Monitoring Assisted Reproductive Technology (SMART) Collaborative: Promoting State-Based Surveillance of ART and Infertility
    Sheree Boulet, Centers for Disease Control and Prevention
     
5:05 PM–5:30 PM   Discussion
   

1:30 PM–2:30 PM

REACTIVE OXYGEN SPECIES, OXIDATIVE STRESS AND REDOX SIGNALING IN DEVELOPMENTAL TOXICOLOGY SYMPOSIUM – Mont Royal

  Chairpersons: Jason M. Hansen, Brigham Young University and Louise M. Winn, Queen's University
1:30 PM–2:10 PM S14 Oxidative Stress and Redox Signaling in Toxicology
    Barbara F. Hales, McGill University
     
2:10 PM–2:50 PM S15 Developmental Toxicants That Alter Conceptual Redox States Produce Differential Effects on the Thiol Proteome
    Craig Harris, University of Michigan
     
2:50 PM–3:30 PM S16 Reactive Oxygen Species, Embryonic Cell Signaling Pathways and Teratogenesis
    Louise M. Winn, Queen's University
     
3:30 PM–3:45 PM   Break — Fontaine B
     
3:45 PM–4:25 PM S17 Reactive Oxygen Species (ROS) Formation, Oxidative DNA Damage and Repair in Teratogenesis
    Peter G. Wells, University of Toronto
     
4:25 PM–5:05 PM S18 Dysregulation of the Redox Proteome in Teratogenesis: Mediation through Nrf2 Activation
    Jason M. Hansen, Emory University
     
5:05 PM–5:30 PM   Discussion
   
5:30 PM–7:30 PM POSTER SESSION 1 AND EXHIBITS ATTENDED – Fontaine B
(Joint with INA, NBTS, and OTIS)
Teratology Society, INA, NBTS, and OTIS Posters
Click Here to Browse Posters

Poster Session 1
(Presenter designated by underlined author.)

P1        Chromium’s Potential to Reduce Birth Defects
Keith JD, Vincent JB, Rasco JF. The University of Alabama, Tuscaloosa, AL, United States.

P2        Inhibition of Thymidylate Synthase Affects Neural Tube Development in Mice
Wang X1,2, Guan Z1, Dong Y2, Wang J1, Zhu Z1, Xu L1, Niu B1,2. 1Capital Institute of Pediatrics, Beijing, China, 2Shanxi Medical University, Taiyuan, China.

P3        N-acetyl-L-cysteine Reduces the Incidence of Specific Malformations in CD-1 Mice
Carney ME1, Miller BM1, Wells KK1, Lam XT1, Wells CB1, Herguth CM1, Hood RD2, Bailey MM1. 1Department of Biological Sciences, Emporia State University, Emporia, KS, United States, 2Ronald D. Hood & Associates, Northport, AL, United States.

P4        Antioxidant Consumption is Associated with Decreased Odds of Congenital Limb Deficiencies
Pace ND1, Siega-Riz AM1, Carmichael SL2, Shaw GM2, Desrosiers TA1, Olshan AF1. 1University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2Stanford University, Stanford, CA, United States.

P5        Lycopene Inhibits Serious Fetal Anomalies Caused by Nicotine via Modulation of Oxidative Stress, Apoptosis, and Inflammation
Park SG, Lin C, Chu SB, Yon J-M, Gwon LW, Lee BJ, Yun YW, Nam S-Y. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.

P6        The Novel Compound 4-O-methylhonokiol Ameliorates Nicotine-Induced Embryotoxicity by Modulating Oxidative Stress and the Related Gene Expression
Gwon LW, Lin C, Yon J-M, Park SG, Chu SB, Lee BJ, Yun YW, Nam S-Y. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.

P7        Punicalagin Attenuates Nicotine-Induced Placental-Yolk Sac Dysfunction Result in Oxidative Embryonic Damage via Improving Vasculogenesis and HIF-1-Mediated Transcriptional Activity
Lin C, Yon J-M, Park SG, Chu SB, Gwon LW, Lee BJ, Yun YW, Nam S-Y. College of Veterinary Medicine and Research Institute of Veterinary Medicine, Chungbuk National University, Cheongju, Republic of Korea.

P8        Maternal Restraint Effects on Cyclophosphamide Teratogenesis
Wells CB1, Carney ME1, Miller BM1, Lam XT1, Kepko DS1, Mueller ML1, Hood RD2, Bailey MM1. 1Emporia State University, Emporia, KS, United States, 2Ronald D. Hood & Associates, Northport, AL, United States.

P9        Implications of Altered Maternal IL-6 Concentrations on Infant Outcomes of Children with Prenatal Alcohol Exposure
Sowell KD1, Uriu-Adams JY1, Graham JL1, Chambers CD6, Coles CD2, Yevtushok L3, Zymak-Zakutnya N4, Wertelecki W5, Keen CL1. 1University of California, Davis, Davis, CA, United States, 2Emory University, Atlanta, GA, United States, 3Rivne Oblast Medical Diagnostic Center and OMNI-Net, Rivne, Ukraine, 4Khmelnytsky Perinatal Hospital and OMNI-Net, Khmelnytsky, Ukraine, 5University of South Alabama, Mobile, AL, United States, 6University of California, San Diego, San Diego, CA, United States.

P10      Interaction between the MTHFR 677C>T Polymorpishm and Periconceptional Folic Acid Supplementation in the Risk of Hypospadias
Dokter EMJ1,3, van Rooij IALM1, Wijers CHW1, Franke B2, van der Biezen JJ3, Feitz WFJ4, van der Zanden LFM1, Roeleveld N1,5. 1Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands, 2Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands, 3Department of Plastic Surgery and Hand Surgery, Medical Centre Leeuwarden, Leeuwarden, Netherlands, 4Department of Urology-Pediatric Urology, Radboudumc Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, Netherlands, 5Department of Pediatrics, Radboudumc Amalia Children’s Hospital, Radboud University Medical Center, Nijmegen, Netherlands.

P11      Copy Number Variants in a Population-Based Investigation of Hypoplastic Right Heart Syndrome
Dimopoulos A1, Sicko R2, Kay DE2, Rigler S3, Fan R1, Romitti P4, Browne M2, Druschel C2, Caggana M2, Brody L5, Mills JL1. 1NICHD, Bethesda, MD, United States, 2New York State Department of Health, Albany, NY, United States, 3Naval Medical Center Portsmouth, Portsmouth, VA, United States, 4University of Iowa, Iowa City, IA, United States, 5NHGRI, Bethesda, MD, United States.

P12      Rare Copy Number Variants in a Population-Based Investigation of Isolated Tracheoesophageal Fistula and Esophageal Atresia
Dimopoulos A1, Sicko R2, Kay DE2, Boghossian N3, Rigler S4, Hagen EM1, Fan R1, Romitti P5, Browne M2, Druschel C2, Caggana M2, Brody L6, Mills JL1. 1NICHD, Bethesda, MD, United States, 2New York State Department of Health, Albany, NY, United States, 3University of South Carolina, Columbia, SC, United States, 4Naval Medical Center Portsmouth, Portsmouth, VA, United States, 5University of Iowa, Iowa City, IA, United States, 6NHGRI, Bethesda, MD, United States.

P13      The Effects of Valproic Acid Exposure on p300 and Its Downstream Targets, nf-κb and pim-1, in p19 Embryonic Carcinoma Cells
Bricker JK, Winn LM. Queen’s University, Kingston, ON, Canada.

P14      Mitotic-Dependent Phosphorylation of LARG by Cdk1
Helms MC1, Grabocka E1, Martz MK1, Suzuki N2, Wedegaertner PB1. 1Thomas Jefferson University, Philadelphia, PA, United States, 2University of Tokyo, Meguro, Tokyo, Japan.

Pharmaceutical Hazard Identification and Risk Assessment

P15      Effects of Prenatal Administration of Therapeutic Doses of Topiramate on Ossification of Bones of Appendicular Skeleton in Rat Fetuses
Fadel RAR1,2, Potu BK1, Sequeira RP3, Salem A-H1,2, Abu-Hijleh MF1. 1Department of Anatomy, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain, 2Department of Anatomy, Faculties of Medicine, Suez Canal University, Ismailia, Egypt, 3Departments of Pharmacology and Therapeutics, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain.

P16      Is Exposure to Benzodiazepines during Pregnancy Increasing the Risk of Spontaneous Abortion?
Sheehy O1, Bérard A1,2. 1Research Center CHU Sainte-Justine, Montréal, QC, Canada, 2Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada.

P17      Intranasal Triamcinolone Use during Pregnancy and the Risk of Adverse Pregnancy Outcomes
Bérard AB1,2, Sheehy OS1, Kurzinger MLK3, Juhaeri JJ4. 1Research Center, CHU Ste-Justine, Montréal, QC, Canada, 2University of Montréal, Montréal, QC, Canada, 3Sanofi, R&D, Global Pharmacovigilance and Epidemiology, Paris, France, 4Sanofi, R&D, Global Pharmacovigilance and Epidemiology, Bridgewater, NJ, United States.

P18      SNRI, Bupropion, and Mirtazapine Use during Pregnancy and the Risk of PPHN
Bérard AB1,2, Sheehy OS1, Bernatsky SB3, Abrahamowitz MA3. 1CHU Ste-Justine, Montréal, QC, Canada, 2University of Montréal, Montréal, QC, Canada, 3McGill University, Montréal, QC, Canada.

P19      Antidepressant, Especially SSRI Use, during Pregnancy and the Risk of Autism Spectrum Disorder: A Meta-Analysis
Boukhris T1, Muanda-Tsobo F1, Bérard A1,2. 1Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada, 2Research Center, CHU Sainte-Justine, Montréal, QC, Canada.

P20      Pregnancy Outcome in Women Treated with Adalimumab for Rheumatoid Arthritis: An Update on the OTIS Autoimmune Diseases in Pregnancy Project
Chambers CD, Johnson DL, Luo Y, Xu R, Jones KL. University of California, San Diego, La Jolla, CA, United States.

P21      Study Design and Recruitment into the Cimzia Pregnancy Exposure Registry: An OTIS Autoimmune Diseases in Pregnancy Project
Chambers CD1, Adams J2, Xu R1, Johnson DL1, Jones KL1. 1University of California, San Diego, La Jolla, CA, United States, 2University of Massachusetts Boston, Boston, MA, United States.

P22      Use of Ondansetron during Pregnancy and Cardiac Defects in the Infant
Danielsson B1, Wikner BN1, Källen B2. 1National Board of Health of Welfare, Stockholm, Sweden, 2Tornblad Institute Lund University, Lund, Sweden.

P23      Quality of Reporting of Malaria Trials during Pregnancy and Its Impact on the Effectiveness of Antimalarial Drug: A Subgroup and a Meta-Regression Analysis
Muanda FTM1,2, Bérard AB1,2. 1University of Montréal, Montréal, QC, Canada, 2Research Center, CHU Sainte-Justine, Montréal, QC, Canada.

P24      Diseases Affecting Thalidomide Embryopathy at around 50 Years of Age
Shiga T1, Shimbo T2, Yoshizawa A1, Hinoshita F1. 1National Center for Global Health and Medicine, Toyama Shinjuku-ku, Tokyo, Japan, 2Ohta Nishinouchi Hospital, Nishinouchi, Koriyama, Fukushima, Japan.

P25      Pregnancy Prevention Programs in Europe: A Multidisciplinary Approach to Isotretinoin Use by Women
Neville AJ1, Pierini A2, Klungsøyr K3, Engeland A4, Charlton RA5, Jordon S6, Jong-van den Berg LTW7, Thayer D6, Bos H J7, Puccini A8, Gini R9, Bettoli V10, Dolk H11. 1IMER (Emilia Romagna Registry of Birth Defects), Ferrara, Italy, 2Institute of Clinical Physiology–National Research Council (IFC–CNR), Pisa, Italy, 3The Norwegian Institute of Public Health, Bergen, Norway, 4University of Bergen, Bergen, Norway, 5University of Bath, Bath, United Kingdom, 6Swansea University, Wales, United Kingdom, 7University of Groningen, Groningen, Netherlands, 8Emilia Romagna Region Health Authority, Emilia Romagna, Italy, 9The Regional Agency for Public Health of Tuscany, Tuscany, Italy, 10University of Ferrara, Emilia Romagna, Italy, 11University of Ulster, Northern Ireland, United Kingdom.

P26      Navigating Unexpected Findings in an EFD Study to Resolution: A Case Report
Katavolos P1, Prell R1, Zane D2, Deng R1, Derby M1, Halpern W1. 1Genentech, Inc., South San Francisco, CA, United States, 2Formerly of Genentech, Inc., South San Francisco, CA, United States.

P27      A Biodistribution and Mechanistic Analysis of FcRn-Mediated Transplacental Transfer of Therapeutic Antibodies In Vitro and In Vivo
Xu Y, Stuart C, Dahlen S, Zhang P, Struble EB. CBER, US Food and Drug Administration, Silver Spring, MD, United States.

P28      Examine Whether Pregnancy and Lactation Labeling is Reflected in the Optimal Sections for the Canadian Product Monograph of New Active Prescription Pharmaceutical Drugs Licensed between the Period of 2009 and 2014
Djulus JD, Pham CP, Mouchantaf RM, Valenzuela AV, Berthiaume MB. Health Canada, Ottawa, ON, Canada.
 
P29      “SEND for DART”: What Is It and When Is It Coming?
Ellison M. Instem, Staffordshire, United Kingdom.

   

7:30 PM–10:00 PM

TS/MARTA STUDENT CAREER EVENT –Salon Le Castillon
(Open to Teratology Society, NBTS, INA, and OTIS Students and Postdoctoral Fellows)

 

 





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