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Annual Meeting 2015

Meeting Program

(Information is subject to change.)

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Wednesday, July 1, 2015

 

 

6:30 AM–7:30 AM TERATOLOGY SOCIETY 34TH ANNUAL VOLLEYBALL GAME – Parc Jeanne-Mance
   
7:30 AM–8:30 AM EDUCATION COMMITTEE MEETING – Fundy
   
8:00 AM–2:00 PM REGISTRATION OPEN – Registration Desk
   
8:00 AM–2:00 PM

SPEAKER READY ROOM OPEN – St. Lambert

   
8:30 AM–9:30 AM TERATOLOGY SOCIETY AND EUROPEAN TERATOLOGY SOCIETY EXCHANGE LECTURE – Westmount
  Endocrine Disruptors: A Regulatory Solution in Search of a Problem?
  Chairpersons: Manon Beekhuijzen, WIL Research Europe BV and Susan L. Makris, US Environmental Protection Agency
  Teratology Society (L2)
Endocrine Disruptors: Are They Causing Adverse Effects in Humans?
Elaine Z. Francis, Sandcastle Toxicology Associates
  European Teratology Society (L3)
Endocrine Disruptors: Are Regulations the Solution?
Nina Hallmark, Bayer SAS
   

9:30 AM–12:30 PM

CEREBRAL PALSY: HISTORY, MECHANISMS, AND PREVENTION SYMPOSIUM – Westmount

  Chairpersons: Nigel Paneth, University of Michigan and L. David Wise (ret.)
9:30 AM–9:45 AM   Introduction
     
9:45 AM–10:15 AM S32 Birth Defects and Cerebral Palsy
    Karin B. Nelson, National Institute of Neurological Disorders and Stroke (ret.)
     
10:15 AM–10:45 AM S33 The Causation and Prevention of Cerebral Palsy
    Nigel Paneth, University of Michigan
     
10:45 AM–11:15 AM   Warkany Tea — Montréal Ballroom Foyer
     
11:15 AM–11:45 AM S34 Clinical Diagnosis and Management of Cerebral Palsy
    Peter Rosenbaum, McMasters University
     
11:45 AM–12:15 PM S35 Neuroprotection and Treatment of Cerebral Palsy
    Michael V. Johnston, Kennedy Krieger Institute
     
12:15 PM–12:30 PM   Discussion
   
9:30 AM–12:30 PM PLATFORM SESSION 4 – Mont Royal
  Alternative Models
  Chairpersons: Wafa A. Harrouk, US Food and Drug Administration and Nicole C. Kleinstreuer, ILS/NICEATM
Presenting author is underlined.
     
9:30 AM–9:45 AM   Introduction
     
9:45 AM–10:00 AM 33 Evaluation of 1066 ToxCast Chemicals in a Human Stem Cell Assay for Developmental Toxicity
   

Knudsen TB1, Judson RS1, Baker NC1,2, Leung MCK1. 1US Environmental Protection Agency, NCCT, Research Triangle Park, NC, United States, 2Lockheed-Martin, Research Triangle Park, NC, United States.

   

 

10:00 AM–10:15 AM 34 Compound Ranking Using a Biomarker-Based Human Pluripotent Stem Cell In Vitro Assay for Developmental Toxicity: Chemotype Coverage and Case Studies
   

Palmer JA, Egnash LA, Smith AM, Burrier RE, Donley ELR, Kirchner FR. Stemina Biomarker Discovery, Inc., Madison, WI, United States.

   

 

10:15 AM–10:30 AM 35 Comprehensive Maternal Serum Proteomics for Biomarkers Discovery in Noninvasive Prenatal Diagnosis of Congenital Heart Defects
   

Yuan Z, Chen L, Gu H, Li J, Wei X. Shengjing Hospital, China Medical University, Shenyang, China.

     
10:30 AM–10:45 AM 36

Vascular Developmental Toxicity of TNP-470 and 5HPP-33 Assessed with ToxCastDB and Anchored to Functional Assays for Angiogenesis and Embryogenesis

   

Knudsen TB1, Franzosa JA1, Baker NC1,2, Spencer RS2, Hunter ES1, Kleinstreuer NC3, Ellis-Hutchings R4, Carney EW4. 1US Environmental Protection Agency, Research Triangle Park, NC, United States, 2Lockheed-Martin, Research Triangle Park, NC, United States, 3ILS/NICEATM, Research Triangle Park, NC, United States, 4The Dow Chemical Company, Midland, MI, United States.

     
10:45 AM–11:15 AM   Warkany Tea—Montréal Ballroom Foyer
     
11:15 AM–11:30 AM 37 A 3-D In Vitro Mini-Brain Model to Study Parkinson’s Disease
   

Pamies D1, Wiersma DMM1, Block K1, Pardo CA2, Barreras P2, Kyro K3, Leist M4, Hartung T1, Hogberg H1. 1Center for Alternatives to Animal Testing, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States, 2Department of Neurology, Division of Neuroimmunology and Neuroinfectious Disorders, Johns Hopkins University, Baltimore, MD, United States, 3US Army Edgewood Chemical Biological Center, Aberdeen Proving Grounds, Aberdeen, MD, United States, 4Doerenkamp-Zbinden Chair for In Vitro Toxicology and Biomedicine, University of Konstanz, Universitätsstr, Konstanz, Germany.

     
11:30 AM–11:45 AM 38 Prenatal Alcohol Exposure and Cardiac Neural Crest Ablation Both Result in Similar Defects in Cardiac Function and Structure
   

Karunamuni G, Ma P, Peterson LM, Gu S, Doughman YQ, Jenkins MW, Rollins AM, Watanabe M. Case Western Reserve University, Cleveland, OH, United States.

     
11:45 AM–12:00 Noon 39 Using ToxCast/Tox21 HTS Assays to Assess Endocrine Disruption
    Kleinstreuer NC1, Allen D1, Casey WM2. 1ILS/NICEATM, Research Triangle Park, NC, United States, 2NIH/NIEHS/DNTP/NICEATM, Research Triangle Park, NC, United States.
     
12:00 Noon–12:15 PM 40 Triphenyl Phosphate and Isopropylated Triphenyl Phosphates Induce Differentiation of Murine Embryonic 3T3-L1 and Human Preadipocytes to Mature Adipocytes
   

Tung EWY, Boucher JG, Ahmed S, Atlas E. Health Canada, Ottawa, ON, Canada.

     
12:15 PM–12:30 PM 41 An Evaluation of Daphnia pulex As a Model Organism for Evaluating Multi-Stressor Interactions across the Lifespan
   

Gohlke JM1, Doke D2, Hudson SL1, Dawson JA1, Shwartz TS1, Roberts JE1. 1University of Alabama at Birmingham, Birmingham, AL, United States, 2University for Development Studies, WA, Ghana.

   

12:30 PM–1:30 PM

LUNCH ON YOUR OWN
   
12:30 PM–1:00 PM CELEBRATING ED CARNEY: SCIENTIST, FRIEND, AND MUSICIAN– Westmount
  Chairpersons: George P. Daston, Procter & Gamble Company and Belen Tornesi, AbbVie Inc.
   
1:30 PM–4:30 PM MECHANISMS OF POSTNATAL REPRODUCTIVE DEVELOPMENT/PUBERTY, AND METHODS FOR EVALUATION WORKSHOP – Westmount
  Chairpersons: Susan B. Laffan, GlaxoSmithKline and Kary E. Thompson, Bristol-Myers Squibb
1:30 PM–1:45 PM   Introduction
     
1:45 PM–2:15 PM W11 Improving the Assessment of Endocrine Disrupting Chemicals (EDC) Effects on Puberty
    Tammy E. Stoker, US Environmental Protection Agency
     
2:15 PM–2:45 PM W12 In Vivo Assessments of Puberty with Focus on Female Rodent Model
    Susan B. Laffan, GlaxoSmithKline
     
2:45 PM–3:00 PM   Break
     
3:00 PM–3:30 PM W13 Assessing the Effect of Long-Acting GLP-1 Agonists on Onset of Puberty in Rats
    Kary E. Thompson, Bristol-Myers Squibb
     
3:30 PM–4:00 PM W14 Clinical Perspectives on Environmental Influences on Pubertal Timing
    Mary M. Lee, University of Massachusetts Memorial Children’s Medical Center
     
4:00 PM–4:30 PM   Discussion
   
1:30 PM–4:30 PM PLATFORM SESSION 5 – Mont Royal
  Mechanisms of Teratogenesis
  Chairpersons: Michelle Carll Helms, Thomas Jefferson University and Sonja A. Rasmussen, Centers for Disease Control and Prevention
Presenting author is underlined.
     
1:30 PM–1:45 PM   Introduction
     
1:45 PM–2:00 PM 42 Genetic Differences in Pup Survival, Biochemistry, and Gene Expression following Developmental Exposure to Polychlorinated Biphenyls
   

Curran CP, Klinefelter K, Brown J, Bates CT, Kromme M, Hays B, Weimer J, Hampton S. Northern Kentucky University, Highland Heights, KY, United States.

   

 

2:00 PM–2:15 PM 43 Expression Profiles of a Subset of Placental Imprinted Genes May Predict Infant Neurobehavioral Outcomes
   

Green BB1, Kappil M2, Lambertini L2, Armstrong DA1, Geurin DG1, Lester BM3, Chen J2, Marsit CJ1. 1Geisel School of Medicine at Dartmouth College, Hanover, NH, United States, 2Icahn School of Medicine at Mount Sinai, New York, NY, United States, 3Alpert Medical School of Brown University and Women and Infants Hospital, Providence, RI, United States.

   

 

2:15 PM–2:30 PM 44 Disruption in Placental Expression of Imprinted Genes is Associated with Birthweight
   

Kappil M1, Lambertini L1, Guerin D2, Green B2, Marsit C2, Chen J1. 1Icahn School of Medicine at Mount Sinai, New York, NY, United States, 2Geisel School of Medicine at Dartmouth, Hanover, NH, United States.

     
2:30 PM–2:45 PM 45

Epigenetic Modifications of Histone H3 in Brains and Livers of Fetal DNA Repair-Deficient Oxoguanine Glycosylase 1 (ogg1) Knockout Mice Exposed In Utero to Ethanol

   

Bhatia S1, Wells PG1,2. 1Dept. of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada, 2Dept. of Pharmacology & Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.

     
2:45 PM–3:00 PM  

Break—Montréal Ballroom Foyer

     
3:00 PM–3:15 PM 46 Heritable Germline Chromatin Desilencing Mediated by the Environmental Alteration of the Epigenome
   

Camacho J, Kreik S, Allard P. University of California, Los Angeles, Los Angeles, CA, United States.

     
3:15 PM–3:30 PM 47 Copper Influences on Markers of Motility in Endothelial Cells: Potential Role in the Development of the Vascular System in Embryos
   

Lanoue L, Demyan L, Keen CL. University of California, Davis, CA, United States.

     
3:30 PM–3:45 PM 48 The Role of JNK Activation in Cell Survival after Cadmium Exposure in Micromass Culture of Mouse Embryo Limb Bud Cells
    Kapron CM, Alhoesh A. Trent University, Peterborough, ON, Canada.
     
3:45 PM–4:00 PM 49 The Role of Previous Miscarriages and Single Nucleotide Polymorphisms in Developmental Genes in the Etiology of Anorectal Malformations
   

van der Putte R1, Wijers CHW1, de Blaauw I2,3, Marcelis CLM4, Sloots CEJ3, Brooks A5, Broens PMA6, Brunner HG4, van der Zanden LFM1, van Rooij IALM1, Roeleveld N1,7. 1Department for Health Evidence, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands, 2Department of Surgery-Pediatric Surgery, Radboudumc Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands, 3Department of Pediatric Surgery, Sophia's Children's Hospital, Erasmus Medical Centre, Rotterdam, Netherlands, 4Department of Human Genetics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, Netherlands, 5Department of Clinical Genetics, Erasmus Medical Centre, Rotterdam, Netherlands, 6Department of Surgery, Division of Pediatric Surgery, University Medical Centre Groningen, Groningen, Netherlands, 7Department of Pedatrics, Radboudumc Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, Netherlands.

   

 

4:00 PM–4:15 PM 50 Copy-Number Variant Analysis of Classic Heterotaxy Highlights the Importance of Body Patterning Pathways
   

Hagen EM1, Sicko R2, Kay DE2, Rigler S3, Dimopoulos A1, Warmerdam B4, Ahmad S4, Doleman M4, Fan R1, Romitti P5, Browne M2, Caggana M2, Brody L6, Shaw G7, Jelliffe-Pawlowski L8,9, Mills JL1. 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States, 2New York State Department of Health, Albany, NY, United States, 3Naval Medical Center, Portsmouth, VA, United States, 4California CBDMP, Sacramento, CA, United States, 5Universtiy of Iowa, Iowa City, IA, United States, 6National Human Genome Research Institute, Bethesda, MD, United States, 7Stanford University, Stanford, CA, United States, 8California Genetic Disease Screening Program, Sacramento, CA, United States, 9Univesity of California, San Francisco, San Francisco, CA, United States.

   

 

4:15 PM–4:30 PM 51 Copy Number Variants in a Population-Based Investigation of Klippel Trenaunay Weber Syndrome
   

Dimopoulos A1, Sicko R2, Kay DE2, Rigler S3, Fan R1, Romitti P4, Browne M2, Druschel C2, Caggana M2, Brody L5, Mills JL1. 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States, 2New York State Department of Health, Albany, NY, United States, 3Naval Medical Center Porthsmouth, Porthsmouth, VA, United States, 4University of Iowa, Iowa city, IA, United States, 5National Human Genome Research Institute, Bethesda, MD, United States.

     
   
4:45 PM–6:15 PM BUSINESS MEETING – Westmount
   
6:30 PM–7:30 PM BANQUET RECEPTION – Montréal Ballroom Foyer
   
7:30 PM–11:00 PM BANQUET – Outremont

 

Travel Awards
James C. Bradford Memorial Student Poster Awards
Wilson Presentation Awards
Marie W. Taubeneck Award
Edward W. Carney Distinguished Service Award
Recognition of Other Awards Presented Throughout the Week

 

 

 

 





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