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Annual Meeting 2016

Meeting Program

(Information is subject to change.)

Overview | Friday | Saturday | Sunday | Monday | Tuesday | Wednesday | Thursday

Monday, June 27, 2016
7:00 AM–6:00 PM REGISTRATION OPEN – Texas Ballroom Foyer
7:00 AM–6:00 PM SPEAKER READY ROOM OPEN – Crockett A
7:00 AM–8:00 AM 2017 PROGRAM COMMITTEE MEETING – Republic B
7:30 AM–8:00 AM MORNING COFFEE AND PASTRIES – Texas Ballroom B
8:00 AM–9:00 AM KEYNOTE SPEAKER – Texas Ballroom D
  Translating Rapid Whole Genome Sequences into Precision Medicine for Babies in Intensive Care Nurseries (L4)
  Chairperson: Sonja A. Rasmussen, Centers for Disease Control and Prevention
  Speaker: Stephen F. Kingsmore, Rady Pediatric Genomics and Systems Medicine Institute
9:00 AM–12:00 Noon WILEY-BLACKWELL SYMPOSIUM – Texas Ballroom D
  (Joint with DNTS)
  Neurodevelopmental Deficits from Fetal Exposure to Methamphetamine, Cocaine, and Alcohol: Emerging Mechanisms and Human Consequences
  Chairpersons: Charles V. Vorhees, Cincinnati Children's Hospital Medical Center and Peter G. Wells, University of Toronto
9:00 AM–9:05 AM   Introduction
9:05 AM–9:45 AM S14 Oxidative Stress Mechanisms of Neurodevelopmental Deficits Initiated by Methamphetamine and Ethanol
    Peter G. Wells, University of Toronto
9:45 AM–10:25 AM S15 Effects of Methamphetamine on Brain and Behavioral Development
    Charles V. Vorhees, Cincinnati Children's Hospital Medical Center
10:25 AM–10:40 AM   Break–Texas Ballroom B
10:40 AM–11:20 AM S16 Dopaminergic Mechanisms of Cocaine-Initiated Neurodevelopmental Deficits
    Gregg D. Stanwood, Florida State University
11:20 AM–12:00 Noon S17 Human Neurodevelopmental, Behavioral, and Growth Consequences of Exposure to Prenatal Methamphetamine and Alcohol
    Lynne M. Smith, Harbor-UCLA Medical Center
9:00 AM–12:00 Noon PLATFORM SESSION 2 – Texas Ballroom F
  Developmental Teratology and Toxicology
Chairpersons: Barbara F. Hales, McGill University and Alan M. Hoberman, Charles River Laboratories
  Presenting author is underlined.
9:00 AM–9:15 AM   Introduction
9:15 AM–9:30 AM 11 Untreated and Ethanol-Exposed DNA Repair-Deficient Oxoguanine Glycosylase 1 (Ogg1) Knockout Progeny May Be Susceptible to Postnatal Neurodevelopmental Abnormalities Mediated by Epigenetic Mechanisms
Bhatia S
1, Wells PG1,2. 1Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada, 2Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
9:30 AM–9:45 AM 12 MARCKS Acetylation Regulated by TIP60 and SIRT2 Prerequisite for Phosphorylation Dismantles Its Cellular Organelle Protection and Neural Tube Closure in Diabetes
Yang P
, Xu C, Reece EA, Yang P. University of Maryland, Baltimore, Baltimore, MD, United States.
9:45 AM–10:00 AM 13 Ocular Features and Limb Anomalies in Patients with Microcephaly and Presumed Zika Virus Congenital Infection in Pernambuco, Brazil
Ventura CV1,3, Ventura LO1,2, Maia M3, Belfort Jr R3. 1Altino Ventura Foundation (FAV), Recife, PE, Brazil, 2HOPE Eye Hospital, Recife, PE, Brazil, 3Federal University of São Paulo (Unifesp), São Paulo- SP, Brazil. 
10:00 AM–10:15 AM 14 Genetic Susceptibility to Thyroid Hormone Disruption and Immunotoxicity in PCB-Treated Mice
Curran CP
, Colter BH, Villalona Y, Caudill S. Northern Kentucky University, Highland Heights, KY, United States.
10:15 AM–10:30 AM 18 QAC-Induced Neural Tube Defects by Dosing and Environmental Exposure
Hrubec TC1,2, Melin VE1,2, Shea CS1, Potineni H2, Razvi RM1, Patel HR1, Repine CM1, Chapman TW1. 1E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States, 2VA-MD College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.
10:30 AM–10:45 AM   Break—Texas Ballroom B
10:45 AM–11:00 AM 16 The Germ Cell-Specific Loss of the Copper Transporter, Ctr1, during Embryogenesis Results in Severe Disruption of Spermatogenesis in Mice
Di Bona KR1, Ghaffari R2, Richburg JH1,2. 1Center for Molecular and Cellular Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX, United States, 2Institute of Cellular and Molecular Biology, College of Natural Sciences, The University of Texas at Austin, Austin, TX, United States.
11:00 AM–11:15 AM 17 Adverse Effect of Valproic Acid on an In Vitro Gastrulation Model Entails Activation of Retinoic Acid Signaling: A Potential Mechanism for Its Teratogenic Action
Marikawa Y, Li A. University of Hawaii, Honolulu, HI, United States.
11:15 AM–11:30 AM 15 Differences in Ambient and Oral Exposure to Quaternary Ammonium Compounds in Mice
Razvi RM1, Patel HR1, Repine CM1, Chapman TW1, Melin VE1,2, Shea CS1,2, Hrubec TC1,2. 1E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States, 2VA-MD College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.
11:30 AM–11:45 AM 19 Lack of Active Placental Transfer of Certolizumab Pegol: Preclinical and Clinical Data
Mahadevan U1, Porter C2, Armstrong-Fisher S3,4, Baker T5, Kevorkian L5, Nesbitt A5. 1UCSF Medical Center, San Francisco, CA, United States, 2Department of Immunopathology, NHS Grampian, Aberdeen, United Kingdom, 3Academic Transfusion Medicine Unit, University of Aberdeen, Aberdeen, United Kingdom, 4Scottish National Blood Transfusion Service, Aberdeen, United Kingdom, 5UCB Pharma, Slough, United Kingdom.
11:45 AM–12:00 Noon 20 Are Quaternary Ammonium Compounds Immunotoxic?
McDonald VA1, Hrubec TC2,3. 1Department of Biology, Virginia Tech, Blacksburg, VA, United States, 2E. Via College of Osteopathic Medicine, Virginia Campus, Blacksburg, VA, United States, 3VA-MD College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.
12:00 Noon–1:30 PM LUNCH ON YOUR OWN
  (By Invitation Only)
12:00 Noon–1:30 PM STUDENT AFFAIRS COMMITTEE MEETING – Meet at Registration
1:30 PM–5:30 PM MARCH OF DIMES SYMPOSIUM – Texas Ballroom D
New Approaches to the Treatment of Birth Defects
  Chairpersons: Jan M. Friedman, University of British Columbia and Joe Leigh Simpson, March of Dimes Foundation
1:30 PM–2:15 PM S18 Tuberous Sclerosis Complex: From Bedside to Bench and Back Again
    Hope Northrup, University of Texas Medical School at Houston
2:15 PM–3:00 PM S19 Treatment of Lysosomal Storage Diseases: Lessons for Other Genetic Disorders
    Lorne Clarke, University of British Columbia, Vancouver
3:00 PM–3:15 PM   Break–Texas Ballroom B
3:15 PM–4:00 PM S20 Bone Marrow Transplantation and Umbilical Cord Blood Transplantation for Inborn Errors of Metabolism
    Vinod K. Prasad, Duke University
4:00 PM–4:45 PM S21 In Utero Treatment of Meningomyelocele: Open and Minimally Invasive Fetal Surgery
    William E. Whitehead, Texas Children's Hospital
4:45 PM–5:30 PM S22 In Utero Treatment of Cardiac Malformations
    Wayne Tworetzky, Boston Children's Hospital
  (Joint with DNTS)
  Chairpersons: Thomas B. Knudsen, US Environmental Protection Agency and William Slikker Jr., National Center for Toxicological Research, US FDA
1:30 PM–1:35 PM   Introduction
    Thomas B. Knudsen, US Environmental Protection Agency
1:35 PM–2:20 PM S23 Assembly of Stem Cell-Derived Human Tissues for Screening Applications
    William Murphy, University of Wisconsin
2:20 PM–3:05 PM S24 Blood-Brain-Barrier Development and Function
    Sherry Ferguson, National Center for Toxicological Research, US FDA
3:05 PM–3:20 PM   Break–Texas Ballroom B
3:20 PM–4:05 PM S25 High-Throughput Screening of Zebrafish to Identify Modifiers of Nervous System Development and Function
    Randall T. Peterson, Harvard Medical School
4:05 PM–4:50 PM S26 Human Neurovascular Unit On-A-Chip: Microscale Systems for Tissue-Level Response
    John Wikswo, Vanderbilt University
4:50 PM–5:30 PM   Discussion
(Joint with DNTS and OTIS)
  Teratology Society Posters P1–P18
DNTS Posters P01–P12
OTIS Posters 1–13
Click Here to Browse Posters

Poster Session 1
(Presenter designated by underlined author.)

P1 Regulatory Research to Support Food-Contact Infant Safety Assessment at US Food and Drug Administration
Neal-Kluever AP1, Aungst J1, Wu Y1, Liu J2, Shackelford M1, Ogungbesan A1, Gu Y1, Jacobs K1. 1US Food and Drug Administration, CFSAN/OFAS/DFCN, College Park, MD, United States, 2Oak Ridge Institute for Science and Education, Oak Ridge, TN, United States.

P2 Pre- and Postnatal Toxicity Assessment in Rabbits with Evacetrapib, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor
Hilbish KG1, Breslin WJ1, Cannady EA1, Edwards TL2. 1Lilly Research Laboratories, Corporate Center, Indianapolis, IN, United States, 2WIL Research, Ashland, OH, United States.

P3 Identification of the Novel Serum Biomarkers for the Prenatal Noninvasive Diagnosis of Neural Tube Defects
Yuan YZ. Shengjing Hospital, China Medical University, Shenyang, China.

P4 The Association between Maternal Diabetes and Congenital Heart Defect Phenotypes in Texas and Updated Meta-Analysis
Hoang TT1, Marengo LK2, Mitchell LE1, Canfield MA2, Agopian AJ1. 1University of Texas School of Public Health, Houston, TX, United States, 2Texas Department of State Health Services, Houston, TX, United States.

P5 Seeing Spots in Front of Your Eyes?—Investigating Nuclear Cataracts in Fetal Rats
Bailey GP1, Van Heerden M1, Roosen W1, Ndifor A2. 1PD&S, Janssen Research and Development, Beerse, Belgium, 2Janssen Research and Development, La Jolla, California, United States.

P6 The WHO Essential Medicines List Ignores the Concerns of the Pregnant Women
Lamm SH1,2, Polifka JE3, Ferdosi H1. 1Center for Epidemiology and Maternal and Child Health, Consultants in Epidemiology and Occupational Health (CEOH), Washington, DC, United States, 2Georgetown University School of Medicine, Washington, DC, United States, 3University of Washington School of Medicine, Seattle, WA, United States.

P7 Skeletal Development in the Fetuses Following Administration of Diazepam to Pregnant Rats
Fadel RA1,2, Dessouki SK2, Mostafa NM2, Daoud AW2. 1Arabian Gulf University, Manama, Bahrain, 2Suez Canal University, Ismailia, Egypt.

P8 Degenerative Changes in the Cervical Spine Are More Common in Middle-Aged Patients with Thalidomide Embryopathy Than in Healthy Individuals
Ghassemi Jahani S-A1, Danilesson A1, Ab-Fawaz R2, Hebelka H2, Danielson B2, Brisby H1. 1Institute of Clinical Sciences Sahlgrenska Academy, Department of Orthopedics, University of Gothenburg, Gothenburg, Sweden, 2Institute of Clinical Sciences Sahlgrenska Academy, Department of Radiology, Gothenburg, Sweden.

P9 Prenatal Alcohol Exposure: Impact on Child Nutritional Outcomes
Chima HS1, Uriu-Adams JY1, Chambers CD2, Coles CD3, Yevtushok L4, Zymak-Zakutnya N5, Wertelecki W6, Keen CL1. 1University of California, Davis, Davis, CA, United States, 2University of California, San Diego, San Diego, CA, United States, 3Emory University, Atlanta, GA, United States, 4Rivne Oblast Medical Diagnostic Center and OMNI-Net, Rivne, Ukraine, 5Khmelnytsky Perinatal Hospital and OMNI-Net, Khmelnytsky, Ukraine, 6University of South Alabama, Mobile, AL, United States.

P10 Normal Offspring of 22 Year Old Male and 17 Year Old Female Recreationally Abusing Synthetic Cannabinoid K2 and Cathinone "Bath Salts"
Scalzo AJ1,2, Braddock SR1,3. 1Department of Pediatrics, Saint Louis University School of Medicine, St. Louis, MO, United States, 2Division of Medical Toxicology, St. Louis, MO, United States, 3Division of Medical Genetics, St. Louis, MO, United States.

P11 Evaluation of Reproductive Health Effects for the Caffeine in an Energy Drink
Hixon M, Beyer L. Gradient, Cambridge MA, United States.

P12 Where We've Come from: A Historical Review of Infant Survival of Spina Bifida
Pace ND. University of North Carolina at Chapel Hill, Chapel Hill, NC, United States.

P13 Effects of Micronutrient Deficient Diet on Maternal Health during Pregnancy
Memon S, Bano U. Liaquat University of Medical & Health Sciences, Jamshoro, Sindh, Pakistan.

P14 Impact of SSRI Exposure on Neural Crest Stem Cells
Cabrera RM, Vichier-Guerre C, Parker M, Pomerantz Y, Finnell RH. University of Texas at Austin, Austin, TX, United States.

P15 Report of Congenital Birth Defects in a Third Level University Hospital from the North of México: Cases from 2013 to 2015
Fernandez Gancedo A, Serrano Garza AM, Amaro Lara MK, Ibarra Ramirez M, Martinez De Villarreal L. Departamento de Genética, Facultad de Medicina y Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico.

P16 Maternal Overweight and Obesity as Risk Factors for Congenital Cardiac Disease in a Third-Level Care Hospital from Northeast Mexico
Hinojosa Amaya AB, Fernandez Gancedo A, Ibarra Ramírez M, Martinez de Villarreal L. Departamento de Genética, Facultad de Medicina y Hospital Universitario, Monterrey, Nuevo León, Mexico.

P17 Should We Treat or Not Mildly to Moderately Depressed Pregnant Women during Pregnancy?
Dandjinou M1,2, Sheehy O2, Bérard A1,2. 1University of Montreal, Montreal, QC, Canada, 2CHU Ste Justine, Montreal, QC, Canada.

P18 A Systematic Review of Transgenerational Toxicological Studies after Gestational Exposure to Environmental Chemicals
Euling S1, Makris S1, Walker T1, Gray Jr LE2, Iyer P3. 1NCEA/ORD, US EPA, Washington, DC, United States, 2NHEERL/TAD, US EPA, Research Triangle Park, NC, United States, 3California EPA, OEHHA, Sacramento, CA, United States.


7:30 PM–10:00 PM

– Texas Ballroom A
(Open to Teratology Society, DNTS, and OTIS Students and Postdoctoral Fellows)


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