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Annual Meeting 2016

Meeting Program

(Information is subject to change.)

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Tuesday, June 28, 2016
6:30 AM–6:00 PM REGISTRATION OPEN – Texas Ballroom Foyer
– Texas Ballroom D
  (Sunrise Mini Course Registrants Only)
7:00 AM–8:30 AM SUNRISE MINI COURSE – Texas Ballroom D
(Separate Registration Required)
  "Big Data"
  Organized by the Education Committee, Chairperson, Chris J Stodgell, University of Rochester
7:00 AM–7:45 AM   Diagnosis and Management of Big Data: Practical Considerations for Prospective Biomedical Studies
    Jeanne Holden-Wiltse, University of Rochester School of Medicine and Dentistry
7:45 AM–8:30 AM   Novel Approaches for the Assessment of Environmentally-Induced Birth Defects
    Rebecca C. Fry, UNC Gillings School of Global Public Health
7:00 AM–6:00 PM SPEAKER READY ROOM OPEN – Crockett A
8:00 AM–8:30 AM MORNING COFFEE AND PASTRIES – Texas Ballroom B
(Joint with OTIS)
  Preventing the Preventable: Where Do We Stand on Fetal Alcohol Spectrum Disorders in 2016?
  Chairperson: Sonja A. Rasmussen, Centers for Disease Control and Prevention
  Speaker: Christina D. Chambers, University of California San Diego
9:00 AM–12:30 PM PUBLIC AFFAIRS SYMPOSIUM – Texas Ballroom D
(Joint with DNTS and OTIS)
  Depression and Its Treatment in Pregnancy
  Chairpersons: Kembra L. Howdeshell, National Institute of Environmental Health Sciences and Asher Ornoy, Hebrew University Hadassah Medical School
9:00 AM–9:05 AM   Introduction
Kembra L. Howdeshell, National Institute of Environmental Health Sciences
9:05 AM–9:45 AM S27 Depression Treatment in Pregnancy: Are We Asking the Right Questions?
Katherine L. Wisner, Northwestern University
9:45 AM–10:25 AM S28 What Can Prenatal Exposure to SSRI Antidepressants Teach Us About Child Development?
Timothy Oberlander, University of British Columbia
10:25 AM–10:40 AM   Break—Texas Ballroom B
10:40 AM–11:20 AM S29 The Safety of Tricyclic Antidepressants and Mood Stabilizers in Pregnancy: What Should We Use for the Treatment of Bipolar Disorders?
Asher Ornoy, Hebrew University Hadassah Medical School
11:20 PM–12:00 Noon S30 New Insights into How SSRIs Shape the Developing Brain: From Mice to Public Health Implications
Jay Gingrich, Columbia University, Sackler Institute of Developmental Psychobiology
12:00 Noon–12:30 PM   Panel Discussion: Mild Psychiatric Diseases in Pregnancy—To Treat or Not Treat
  Chairpersons: Patience Browne, US Environmental Protection Agency and Nicole Churchill Kleinstreuer, NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, NIEHS
9:00 AM–9:30 AM W2 An Exposure-Based Validation List for Developmental Toxicity Screening Assays
    George P. Daston, Procter & Gamble Company
9:30 AM–10:00 AM W3 An Expert-Driven Approach to Identifying Reference Developmental Toxicants
    Elizabeth A. Maull, National Toxicology Program, NIEHS
10:00 AM–10:30 AM W4 Performance of Alternative Assays Against A Range of Reference Developmental Toxicants
    Nicole Churchill Kleinstreuer, National Institute of Environmental Health Sciences,NTP, NICEATM
10:30 AM–10:45 AM   Break–Texas Ballroom B
10:45 AM–11:15 AM W5 A Performance Based Approach to Validation of Computational Tools for Developmental and Reproductive Toxicity
    Patience Browne, US Environmental Protection Agency
11:15 AM–11:45 AM W6 A High-Throughput Screening Assay to Detect Thyroperoxidase Inhibitors
    Steven O. Simmons, National Center for Computational Toxicology, US EPA
11:45 AM–12:15 PM W7 High-Content Screening of Developmental Neurotoxicity in Zebrafish Embryos
    David C. Volz, University of California, Riverside
12:15 PM–12:30 PM   Discussion
12:30 Noon–1:30 PM LUNCH ON YOUR OWN
– Texas Ballroom E
  Chairperson: Cynthia A. Moore, Centers for Disease Control and Prevention
1:30 PM–1:50 PM S31 Increasing Prevalence of Gastroschisis Worldwide
    Kathryn E. Arnold, Centers for Disease Control and Prevention
1:50 PM–2:10 PM S32 The Embryology of Gastroschisis
    Thomas W. Sadler, Consultant
2:10 PM–2:30 PM S33 Genetic and Nongenetic Risk Factors for Gastroschisis
    Sonja A. Rasmussen, Centers for Disease Control
2:30 PM–2:50 PM S34 Potential Role of Common Exposures in Young Women: Sexual Activity, Contraception, Medications, and Drugs
    Christina D. Chambers, University of California, San Diego
2:50 PM–3:10 PM S35 Investigating the Association between Gastroschisis and Biomarkers of Chlamydia Infection and Inflammation
    Marcia Lynn Feldkamp, University of Utah
3:10 PM–3:30 PM   Discussion
  (Joint with OTIS)
  Chairpersons: Richard K. Miller, University of Rochester Medical Center and Sarah G. Obican, University of South Florida
1:30 PM–1:40 PM   Introduction
    Sarah G. Obican, University of South Florida
1:40 PM–2:10 PM S36 Predicting Fetal and Newborn Health: The Role of the Placenta
    Richard K. Miller, University of Rochester Medical Center
2:10 PM–2:50 PM S37 In Utero Imaging of the Human Placenta: Approaches for Diagnosis of Fetal Health
    Alfred Z. Abuhamad, Eastern Virginia School of Medicine
2:50 PM–3:30 PM S38 Human Placental Pathology–Diagnosis in the 21st Century: New Approaches and Techniques
    Carolyn Margaret Salafia, Placental Analytics, Inc.
3:30 PM–3:45 PM   Break–Texas Ballroom B
3:45 PM–4:25 PM S39 Unexpected Beginnings: Role of Pregnancy and Parturition in Establishing Our Microbiome 
    Maxim D. Seferovic, Baylor College of Medicine, Houston
4:25 PM–5:05 PM S40 Placenta-Specific microRNAs and Pregnancy Health
    Yoel Sadovsky, Magee Womens Research Institute, University of Pittsburgh
5:05 PM–5:30 PM   Discussion
3:30 PM–3:45 PM BREAK – Texas Ballroom B
3:45 PM–5:30 PM PLATFORM SESSION 3 – Texas Ballroom E
Chairpersons: James L. Mills, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH and Cynthia A. Moore, Centers for Disease Control and Prevention
  Presenting author is underlined.
3:45 PM–4:00 PM   Introduction
4:00 PM–4:15 PM 21 Exposure to Valproate during Pregnancy: Facial Features and Signs of Autism
Stadelmaier R1, Nasri H2, Deutsch C3, Bauman M4, Adams J5, Stodgell C6, Holmes LB2. 1Albert Einstein College of Medicine, New York, NY, United States, 2MassGeneral Hospital for Children, Boston, MA, United States, 3Eunice Kennedy Shriver Center, Waltham, MA, United States, 4Boston University School of Medicine, Boston, MA, United States, 5University of Massachusetts, Boston, Boston, MA, United States, 6University of Rochester School of Medicine, Rochester, NY, United States.
4:15 PM–4:30 PM 22 Maternal Use of Selective Serotonin-Reuptake Inhibitors and Risk of Persistent Pulmonary Hypertension of the Newborn: An Update of the Current Evidence and Clinical Implications
Alwan S
1, Bandoli G2, Chambers CD2. 1University of British Columbia, Vancouver, BC, Canada, 2University of California, San Diego, San Diego, La Jolla, CA, United States.
4:30 PM–4:45 PM 23 Effects of Opioid Maintenance Therapy on Infant Brain Development
Stephen JM1,2, Flynn L1, Van Meter J1,2, Lowe J2, Bakhireva LN2. 1The Mind Research Network, Albuquerque, NM, United States, 2University of New Mexico, Albuquerque, NM, United States.
4:45 PM–5:00 PM 24 The Need of Orthopedic Care and Physical Activity Level in a Group of Middle-Aged Individuals with Thalidomide Embryopathy
Ghassemi Jahani S-A, Danilesson A, Karlsson J, Brisby H. Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Department of Orthopaedic, Gothenburg, Sweden.
5:00 PM–5:15 PM 25 Health Related Quality of Life and Socio-Demographics in Middle-Aged Individuals with Thalidomide Embryopathy
Danilesson AJ, Ghassemi Jahani S-A. Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg, Department of Orthopaedic, Gothenburg, Sweden.
5:15 PM–5:30 PM 26 Betaine Supplementation Reduces Congenital Defects Induced by Prenatal Alcohol Exposure
Karunamuni G1, Gu S1, Doughman YQ1, Sheehan MM1, Ma P1, Peterson LM1, Linask KK2, Jenkins MW1, Rollins AM1, Watanabe M1. 1Case Western Reserve University, Cleveland, OH, United States, 2University of South Florida, St. Petersburg, FL, United States.
  Teratology Society Posters P19–P46
Click Here to Browse Posters

Poster Session 2
(Presenter designated by underlined author.)

P19 A Six-Month Juvenile Toxicity Study in Cynomolgus Monkeys with Tabalumab: A Human IgG4 Monoclonal Antibody
Breslin WJ1, Newcome DL2, Chellman GJ2, Martin JA1, Blackbourne JL1. 1Lilly Research Laboratories, Indianapolis, IN, United States, 2Charles River Laboratories, Reno, NV, United States.

P20 Seleno-L-methionine Toxicity and Maternal Age in the Model Organism Daphnia pulex
Roberts JE2, Schwartz TS3, Gohlke JM1. 1Virginia Tech, Blacksburg, VA, United States, 2University of Alabama at Birmingham, Birmingham, AL, United States, 3Auburn University, Auburn, AL, United States.

P21 Testing the Waters to Account for Metabolism in the T47D-kbluc Estrogen Receptor Transcriptional Activation Assay
Hannas BR1, Kann L1, Luna L1, LeBaron MJ1, Johnson KJ1, Rasoulpour RJ2. 1Dow Chemical Company, Midland, MI, United States, 2Dow AgroSciences, Indianapolis, IN, United States.

P22 Possible Infant Exposure Reservoirs of Cronobacter Species in Households
Chan MY1,2,3,4, McKenzie EM1,3,4, Williams A1,4, McIntosh TG1,2,4, Smith MA1,2,3,4. 1Department of Environmental Health Science, Athens, GA, United States, 2Center for Food Safety, Athens, GA, United States, 3Regenerative Bioscience Center, Athens, GA, United States, 4University of Georgia, Athens, GA, United States.

P23 A Combinational Approach of Literature Search, (Q)SAR, Read Across, Chemical Grouping, and Professional Judgement in Assessing Developmental Toxicity Potential of Personal Care Ingredients and Their Manufacturing Reagents in Screening for Safer and Innovative Alternatives.
Kim ST1, Sieber S1, Schatz A2. 1Ashland Inc., Dublin, OH, United States, 2Ashland Inc., Bridgewater, NJ, United States.

P24 An In Vitro Teratogen Screen Using 3-D Neuroepithelial Organoids
Steele JW, Sengal AG, Cabrera RM, Finnell RH. Dell Pediatric Research Institute, Department of Nutritional Sciences, University of Texas at Austin, Austin, TX, United States.

P25 Increased Susceptibility to Mammary Carcinogenesis following a Prenatal Exposure to BPA Analogs
Tucker DK1,2, Fenton SE2, Bouknight SA3. 1University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 2NTP Laboratory, NIEHS, Research Triangle Park, NC, United States, 3Pathology Associates, Inc., Charles River Laboratories, Durham, NC, United States.

P26 Aberrant Upstream Kinase Signaling Negatively Impacts Osteogenesis by Impairing FOXO-Mediated Oxidative Stress Response
Walker L, Sparks N, zur Nieden N. University of California, Riverside, Riverside, CA, United States.

P27 Acetylsalicylic Acid: Oral (Gavage) Developmental Toxicity in Sprague-Dawley Rats
Miller L, Gilbert KS. Southern Research, Birmingham, AL, United States.

P28 The Role of Environmental Factors in Pubertal Gynecomastia
Euling S1, Glenn B1, Alcala C2. 1NCEA/ORD, US EPA, Washington, DC, United States, 2Association of Schools and Programs of Public Health Environmental Health Fellow at NCEA/ORD, US EPA, Washington, DC, United States.

P29 A Rat Model for Folate Receptor Antibody-Mediated Behavioral Deficits: Implications of Folate Receptor Autoantibodies in Autism
Desai A, Sequeira J, Quadros E. SUNY Downstate Medical Center, Brooklyn, NY, United States.

P30 Effect of Prenatal Oral Administration of Vernonia amygdalina on the Mothers and Litters of Wistar Rats
Balogun WG1,2, Adebayo IA1, Kamaldin J1, Enaibe BU2. 1Universiti Sains Malaysia, Kepala Batas, Penang, Malaysia, 2University of Ilorin, Ilorin, Kwara, Nigeria.

P31 Assessment of Iodoform Effects on Pregnancy Maintenance and Eye Malformations in a Developmental Toxicity Screen with F344 Rats
Narotsky MG1, Manley AL2, Ola O3. 1US Environmental Protection Agency, Research Triangle Park, NC, United States, 2Oak Ridge Institute for Science and Education (ORISE), Oak Ridge, TN, United States, 3Student Services Contractor, Raleigh, NC, United States.

P32 Development of a 3-D Co-Culture Model Using Human Stem Cells for Studying Embryonic Palatal Fusion
Wolf CJ, Becker C, Das KP, Watkins AM, Belair DG, Abbott BD. US Environmental Protection Agency, Research Triangle Park, NC, United States.

P33 Fertility and Developmental Toxicity Assessment in Rats and Rabbits with Evacetrapib, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor
Hilbish KG1, Breslin WJ1, Cannady EA1, Edwards TL2. 1Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN, United States, 2WIL Research, Ashland, OH, United States.

P34 Retinoic Acid and Maternal Diabetes Developmental Toxicity is Mediated by Gap Junction Disruption in Cardiomyocytes in Culture
Memon S1, Pratten M2. 1Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan, 2The University of Nottingham, Nottingham, United Kingdom.

P35 Estrous Cyclicity Is Altered Following Lung Exposure to Multiwalled Carbon Nanotubes in Mice
Johansson HKL, Lund SP, Kyjovska Z, Jackson P, Wallin H, Vogel U, Hougaard KS. Danish Nanosafety Centre, National Research Centre for the Working Environment, Copenhagen, Denmark.

P36 A 2015 Global Update on Folic Acid-Preventable Spina Bifida and Anencephaly
Kancherla V1, Arth A1, Pachón H1,2, Zimmerman S2, Johnson Q2, Oakley G1. 1Emory University Rollins School of Public Health, Atlanta, GA, United States, 2Food Fortification Initiative, Atlanta, GA, United States.

P37 Vitamin E Decreases the Incidence of Neural Tube Defects Induced by Benzo(a)pyrene in ICR Mice
Ren AG, Lin SS, Wang LL, Huang Y. Peking University, Beijing, China.

P38 BMI and Pregnancy Weigh Gain As Risk Factor for NTD: A Case Study in a Northeast Mexican Third Level Hospital
Fernandez Gancedo A, Hinojosa Amaya AB, Ibarra Ramirez M, Martinez De Villarreal L. Departamento de Genética, Facultad de Medicina y Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, Nuevo Leon, Mexico.

P39 Histone Modifications in Proliferating and Differentiating Human Neural Progenitor Cells after Acute Chlorpyrifos and Arsenic Exposures
Park JJ1,2, Kim HY1,2, Wegner SH1,2, Van Ness KP1, Pacheco SE2, Workman T2, Hong S1, Griffith W2, Faustman EM1,2. 1University of Washington, Seattle, WA, United States, 2Institute of Risk Analysis and Risk Communication, Seattle, WA, United States.

P40 Maternal Psychological Stress and Cyclophosphamide Teratogenisis in CD-1 Mice
Wells CB1, Carney ME1, Miller BM1, Lam XT1, Kepko DS1, Mueller ML1, Hood RD2, Bailey MM1. 1Emporia State University, Emporia, KS, United States, 2Ronald D. Hood & Associates, Northport, AL, United States.

P41 Organotypic Modeling Platform for Adverse Outcome Pathways of Male Reproductive and Developmental Processes
Wilder CS1,2, Wegner SH1,2, Smith MN1,2, Harris S1,2, Hong SW1,2, Griffith WC1,2, Faustman EM1,2. 1Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, United States, 2Institute for Risk Analysis and Risk Communication, University of Washington, Seattle, WA, United States.

P42 Comparing Micro-CT Imaging and Alizarin Red Staining Methods to Examine Fetal Rabbit Skeletons (Dutch Belted) Obtained on Day 29 of Gestation
Solomon HM, Murzyn S, Skedzielewski T, Rendemonti J, Chapman S, Alsaid H. GlaxoSmithKline Pharmaceuticals, King of Prussia, PA, United States.

P43 Microsampling and Microdosing in Mini Rodents
Marien D, Van den Heuvel J, Claessen J, Sas C, Feyen B. Janssen Research & Development, Preclinical Development & Safety, Beerse, Belgium.

P44 Comparison of Juvenile and Adult Rat Study on Toxicokinetics and Toxicity
Wan H, McPherson S, Jin Y. WuXi AppTec, Suzhou, China.

P45 Impacts of Social Housing on Time-Mated Rabbits
Derfler K, Knepley P, Fetter A, Parsons P. Covance Research Products, Inc, Denver, PA, United States.

P46 Enhanced Pre- and Postnatal Development Studies in the Nonhuman Primate Model: Experiences with Social Housing
Henwood SM, Luetjens CM, Fuchs A, Weinbauer G. Covance Laboratories Inc., Madison, WI, United States.



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