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Annual Meeting 2017

Meeting Program

(Information is subject to change.)


Friday, June 23, 2017
3:00 PM–6:00 PM REGISTRATION OPEN – Aspen Foyer
   
3:00 PM–6:00 PM SPEAKER READY ROOM OPEN – Crestone Peak
   

Saturday, June 24, 2017
7:30 AM–6:00 PM REGISTRATION OPEN – Aspen Foyer
   
7:30 AM–6:00 PM SPEAKER READY ROOM OPEN – Crestone Peak
   
8:00 AM–8:30 AM EDUCATION COURSE COFFEE
AND PASTRIES – Aspen Ballroom
(Education Course Session 1 Registrants Only)
   
8:30 AM–12:00 Noon EDUCATION COURSE SESSION 1 – Aspen Ballroom
(Separate Registration Required)
Renal Development: Embryology, Renal Abnormalities and Teratogens, and Clinical Management and Treatment
  Organized by the Education Committee, Chairperson, Kimberly C. Brannen, Merck
8:30 AM–8:40 AM Welcome
  Teratology Society President, Sonja A. Rasmussen, Centers for Disease Control and Prevention
   
8:40 AM–8:45 AM Course Overview
  Education Committee Chairperson, Kimberly C. Brannen, Merck
   
8:45 AM–9:30 AM Embryology
  Francis Fakoya, St. George’s University
   
9:30 AM–10:15 AM Renal Abnormalities: Mechanisms and Pathways
  Indra Gupta, McGill University
   
10:15 AM–10:30 AM Break
   
10:30 AM–11:15 AM Effects on the Developing Renal System in Preclinical Models
  Kendall Frazier, GlaxoSmithKline
   
11:15 AM–12:00 Noon Clinical Management and Treatment
  Michael H. Hsieh, Children's National Health System
   
12:00 Noon–1:30 PM LUNCH ON YOUR OWN
   
12:00 Noon–1:30 PM SCIENCE COMMITTEE MEETING – Mt. Princeton
   
1:30 PM–5:00 PM EDUCATION COURSE SESSION 2 – Aspen Ballroom
(Separate Registration Required)
Epigenetics: A Primer
  Organized by the Education Committee, Chairperson, Kimberly C. Brannen, Merck
1:30 PM–1:35 PM Course Overview
  Education Committee, Chairperson, Kimberly C. Brannen, Merck
   
1:35 PM–2:20 PM Epigenetics Overview
  Heather Burris Beth Israel Deaconess Medical Center
   
2:20 PM–3:05 PM Noncoding RNAs in Development and Teratology
  Rajesh C. Miranda, Texas A&M Health Science Center
   
3:05 PM–3:20 PM Break
   
3:20 PM–4:05 PM Transgenerational and Multigenerational Effects
  Eric Nilsson, Washington State University
   
4:05 PM–4:50 PM Beneficial and Adverse Effects of Epigenetic Changes
 

B. Alex Merrick, National Toxicology Program, NIEHS

   
4:50 PM–5:00 PM Discussion
   
5:30 PM–7:30 PM STUDENT AND POSTDOCTORAL FELLOW MIXER – Pub 17
6:00 PM–9:00 PM COUNCIL 1 MEETING – Mt. Columbia
Committee Reports and Strategic Planning
   

Sunday, June 25, 2017
6:45 AM–7:45 AM STUDENT AFFAIRS COMMITTEE MEETING – Mt. Wilson
   
7:00 AM–6:00 PM REGISTRATION OPEN – Aspen Foyer
   
7:00 AM–6:00 PM SPEAKER READY ROOM OPEN – Crestone Peak
   
7:15 AM–7:45 AM MORNING COFFEE AND PASTRIES –Aspen Foyer
 

(Joint with DNTS)

7:45 AM–8:15 AM PRESIDENT'S WELCOME – Aspen Ballroom
  Teratology Society President, Sonja A. Rasmussen, Centers for Disease Control and Prevention
   
8:15 AM–9:00 AM JOSEF WARKANY LECTURE – Aspen Ballroom
  Eliminating Congenital Zika Syndrome: Lessons Learned from Rubella Elimination (L1)
  (Joint with DNTS and OTIS)
  Chairperson: Sonja A. Rasmussen, Centers for Disease Control and Prevention
  Lecturer: José F. Cordero, University of Georgia
   
9:00 AM–10:00 AM THOMAS H. SHEPARD LECTURE – Aspen Ballroom
  (Joint with OTIS)
 

From the FAS to OTIS: A Long Strange Trip

 

Chairperson: Stephen R. Braddock, Saint Louis University School of Medicine

 

Lecturer: Buzz Chernoff, California Environmental Protection Agency (Retired)

   
10:00 AM–10:30 AM SPOUSE AND GUEST MEET-AND-GREET – Mt. Wilson
  (Open to Teratology Society, DNTS, and OTIS Spouses and Guests)
   
10:05 AM–1:00 PM GRADUATE STUDENT AND POSTDOCTORAL FELLOW PLATFORM SESSION 1 – Aspen Ballroom
  Organized by the Student Affairs Committee
  Chairperson: Dana L. Shuey, Incyte
10:05 AM-10:15 AM   Introduction
     
10:15 AM-10:30 AM 1 Developmental Toxicity Testing of Cigarette Smoke and E-Cigarette Vapor Utilizing Drosophila melanogaster Primary Embryonic Stem Cell Cultures
   

Ubina TM, Juarez J, Gallardo M, Bournias-Vardiabasis N. California State University–San Bernardino, San Bernardino, CA, United States.

     
10:30 AM-10:45 AM 2 Oxidative Stress-Induced Harm Reduction Tobacco Products Misregulates the Development of Bone
   

Sparks NRL, Walker LM, Sera S, zur Nieden NI. University of California–Riverside, Riverside, CA, United States.

     
10:45 AM-11:00 AM 3

Genetic Screening for Ethanol-Sensitive Zebrafish Mutants Identifies a Requirement for Bmp Signaling in Endoderm and Jaw Development

   

Lovely CB, Swartz ME, McCarthy N, Norrie JL, Henegar T, Eberhart JE. University of Texas–Austin, Austin, TX, United States.

     
11:00 AM-11:15 AM   Break-Aspen Foyer
     
11:15 AM-11:30 AM 4 Harm-Reduction Tobacco Products Deleteriously Alter AKT and Other Survival-Related Signaling Pathways during Normal Embryonic Osteogenesis
    Walker LM, Sparks NRL, zur Nieden NI. University of California-Riverside, Riverside, CA, United States.
     
11:30 AM-11:45 AM 5

Changes to Primary Cilia Number and Function in the Neural Tube Following Neurulation-Stage Ethanol Exposure in a Mouse Model of FASD
Boschen KE, Fish EW, van Venrooy AI, Parnell SE. University of North Carolina, Chapel Hill, NC, United States.

     
11:45 AM-12:00 Noon 6

Complex Mixtures of Anti-Androgens at Concentrations below Individual Chemical Effect Levels Produces Reproductive Tract Malformations in the Male Rat
Conley JM1, Lambright CR1, Evans N1, Cardon MC1, Medlock-Kakaley E1,2, Wilson VS1, Gray LE1. 1US EPA/ORD/NHEERL/TAD/RTB, Research Triangle Park, NC, United States, 2US EPA-UNC Cooperative Toxicology Program, Research Triangle Park, NC, United States.

     
12:00 Noon-12:15 PM 7 Folic Acid As a Radioprotectant: Efficacy in Preventing X-Ray Induced Congenital Malformations
Craenen K1,2, Verslegers M1, Craeghs L1,2, Buset J1, Neefs M1, Baatout S1, Moons L2, Benotmane MA1. 1Radiobiology Unit, SCK-CEN, Mol, Belgium, 2Neural Circuit Development and Regeneration Research Group, KUL, Leuven, Belgium.
     
12:15 PM-12:30 PM 8

Effect of Maternal Depression and Prenatal Antidepressant Exposure on Placental Serotoninergic and Glucocorticoids Systems Methylation
Laurent L1, Peñaherrera M2,3, Robinson WP2,3, Oberlander TF2,3, Vaillancourt C1. 1INRS-Institut Armand Frappier, Laval, QC, Canada, 2BC Children's Hospital Research Institute, Vancouver, BC, Canada, 3University of British Columbia, Vancouver, BC, Canada.

     
12:30 PM-12:45 PM 9

Regional Differences and Correlates of Prevalence of Prenatal Alcohol Exposure in Texas As Assessed by PEth in Newborn Dry Blood Spots
Shrestha S1, Williams S1, Miranda R2, Bakhireva L1. 1University of New Mexico, Albuquerque, NM, United States, 2Texas A&M Health Science Center, College of Medicine, Bryan, TX, United States.

     
12:45 PM-1:00 PM 10

Genomic Variations in Ebstein Anomaly and Cardiomyocyte Differentiation
Giannakou AG1, Sicko SRJ2, Kay KDM2, Fan FR5, Jelliffe-Pawlowski PLL3, Shaw SG4, Mills JLM1. 1National Institutes of Health, NICHD, DIPHR, Bethesda, MD, United States, 2Wadsworth Center, NYSDOH, Albany, NY, United States, 3University of California–San Francisco, School of Medicine, San Francisco, CA, United States, 4Stanford School of Medicine, Stanford, CA, United States, Georgetown University, Washington, DC, United States.

   
1:00 PM–2:00 PM LUNCH ON YOUR OWN
   
1:00 PM–2:00 PM GRADUATE STUDENT AND POSTDOCTORAL FELLOW PROFESSIONAL DEVELOPMENT WORKSHOP – Mt. Columbia
Effective Communication: Platforms, Posters, and Professional Settings
(Advance Registration Required)
  Chairperson: Dinesh J. Stanislaus, GlaxoSmithKline
1:00 PM–1:05 PM   Introduction
    Dinesh J. Stanislaus, GlaxoSmithKline
     
1:05 PM–1:20 PM W1

Effective Platform Presentations: Do’s and Don’ts

    Nicole Churchill Kleinstreuer, NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, NIEHS
     
1:20 PM–1:35 PM W2

Effective Posters: Do’s and Don’ts

    Kary E. Thompson, Bristol-Myers Squibb
   

 

1:35 PM–2:00 PM  

Discussion About Professional Settings Interactions

   
2:00 PM–2:30 PM F. CLARKE FRASER NEW INVESTIGATOR AWARD – Aspen Ballroom
 

Antibody Therapeutics: Structure, Function, and Placental Transfer

  Chairperson: Janee Gelineau-van Waes, Creighton University School of Medicine
  Lecturer: Evi Struble, US Food and Drug Administration
   
2:30 PM–3:00 PM JAMES G. WILSON PUBLICATION AWARD – Aspen Ballroom
 

A 2015 global update on folic acid-preventable spina bifida and anencephaly

  Chairperson: Norbert Makori, Charles River
  Lecturer: Vjaya Kancherla, Emory University
   
3:00 PM–3:30 PM PATRICIA RODIER MID-CAREER AWARD FOR RESEARCH AND MENTORING – Aspen Ballroom
 

Project Newborn: What We Have Learned from 20 Years of Research on Prenatal Cocaine Exposure?

  (Joint with DNTS)
  Chairperson: Janee Gelineau-van Waes, Creighton University School of Medicine and Patricia A. Janulewicz Lloyd, Boston University School of Public Health
  Lecturer: Sonia Minnes, Case Western Reserve University
   
3:35 PM–6:30 PM WILEY-BLACKWELL SYMPOSIUM
Developmental Metabolism: Consequences to and from Neural Lineages
– Aspen Ballroom
 

Chairpersons and Scientific Liaison Coalition Representatives: Thomas B. Knudsen, National Center for Computational Toxicology, US EPA and Mary Alice Smith, University of Georgia

3:35 PM–3:50 PM   Introduction
     
3:50 PM–4:25 PM S1 Molecular Pathology of Neural Tube Defects in Diabetic Pregnancies
   

J. Michael Salbaum, Pennington Biomedical Research Center, LSU

     
4:25 PM-4:40 PM   Break - Aspen Foyer
   

 

4:40 PM–5:15 PM S2 Apoptotic Mechanism of Maternal Diabetes-Induced Neural Tube Defects
   

Peixin Yang, University of Maryland–Baltimore

   

 

5:15 PM–5:50 PM S3 Development of Neuroendocrine Systems Governing Energy Homeostasis
    Chen Liu, UT Southwestern University
     
5:50 PM–6:25 PM

S4

Modeling of Developmental Neurotoxicity Using Pluripotent Stem Cell-Derived Neurons and Astrocytes is Generating New Mechanistic Insights
    Steve Stice, University of Georgia
     
6:25 PM–6:30 PM   Closing Remarks
   
3:35 PM–6:30 PM PREGNANCY REGISTRY UPDATES SYMPOSIUM (Joint with OTIS) – Colorado Ballroom A
  Chairpersons: Christina D. Chambers, University of California-San Diego and Lewis B. Holmes, MassGeneral Hospital for Children
3:35 PM–3:40 PM   Welcome and Introduction
    Lewis B. Holmes, MassGeneral Hospital for Children
     
3:40 PM–4:00 PM S5

The Key Role of Social Media in Registry Recruitment

    Nicole Chavez, Communications Consultant
     
4:00 PM–4:20 PM

S6

"Drugs in Breast Milk": Related Data in Pregnancy Registries
    Shinya Ito, The Hospital for Sick Children
   

 

4:20 PM–4:35 PM   Break - Aspen Foyer
     
4:35 PM–4:55 PM S7 How to Interpret Different Findings for the Same Medication Across Pregnancy Registries: The Example of Keppra
    David Miller, UCB Biosciences, Inc
     
4:55 PM–5:15 PM S8 Incorporating Registry Data into the Label—Guidance for the PLRR
    Leyla Sahin, US Food and Drug Administration
     
5:15 PM–5:30 PM S9

Defect Evaluation by Infant Photographs in a Multi-Center Pharmaceutical Clinical Trial
Scheuerle AE1, Kwon P2, Joing M2. 1University of Texas Southwestern Medical Center, Dallas, TX, United States, 2NORA Therapeutics, Inc., Palo Alto, CA, United States.

     
5:30 PM–5:45 PM S11

Distribution by Week and Trimester of Onset among Pregnant Women, US Zika Pregnancy Registry, 2015–2016
Khan S1, Rice ME1, Reynolds MR1, Reagan-Steiner S1, Brown CM5, Lee EH4, Ahmad N2, Macdonald J3, Sommer JN2, Smith LC2, Honein MA1. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2New York State Department of Health, Albany, NY, United States, 3Virginia Department of Health, Richmond, VA, United States, 4New York City Department of Health and Mental Hygiene, Queens, NY, United States, 5Massachusetts Department of Public Health, Boston, MA, United States.

     
5:45 PM–6:00 PM S10

Prevalence of Small for Gestational Age and Preterm Birth Among Infants Born to Women with Laboratory Evidence of Possible Zika Virus Infection During Pregnancy, US Zika Pregnancy Registry, December 2015–December 2016
Fleck-Derderian S1, Jones AM1, Simon EL1, Newsome K1, Lee EH2, Ahmad N3, Dunn JE4, Smith LC3, White JL3, Honein MA1. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2New York City Department of Health and Mental Hygiene, New York City, NY, United States, 3New York State Department of Health, Albany, NY, United States, 4Massachusetts Department of Public Health, Boston, MA, United States.

     
6:00 PM–6:15 PM S12

Pregnancy and Lactation Labeling Rule (PLLR) in Practice: More Human Observational Data Needed
Wurst KE1, Cunnington M3, Powell M2, Lee TJ1. 1GlaxoSmithKline, Collegeville, PA, United States, 2GlaxoSmithKline, Research Triangle Park, NC, United States, 3GlaxoSmithKline, Stevenage, United Kingdom.

     
6:15 PM–6:30 PM S13

Lactation Study Challenges and Solutions
Hurst N1, Covington D2. 1PPD, Inc., Morrisville, NC, United States, 2Evidera, Wilmington, NC, United States.

   
6:35 PM–7:00 PM CELEBRATING THE LIFE OF THOMAS H. SHEPARD – Aspen Ballroom
  (Joint with OTIS)
  Chairpersons: Sonja A. Rasmussen, Centers for Disease Control and Prevention and Stephen R. Braddock, Saint Louis University School of Medicine
 

Speakers: Elaine M. Faustman, University of Washington (S14) and
Godfrey P. Oakley Jr., Emory University (S15)

   
7:00 PM–8:30 PM WELCOME RECEPTION, GRADUATE STUDENT AND POSTDOCTORAL FELLOW RESEARCH SHOWCASE, AND EXHIBITS ATTENDED – Capitol Peak A
(Joint with DNTS)
   
8:30 PM–9:00 PM NEW MEMBER "SUNDAE" NIGHT SOCIAL - Crystal Peak C
  (By Invitation Only)
   
8:30 PM–9:30 PM PUBLICATIONS COMMITTEE MEETING - Mt. Princeton

Monday, June 26, 2017
7:00 AM–6:00 PM REGISTRATION OPEN – Aspen Foyer
   
7:00 AM–6:00 PM SPEAKER READY ROOM OPEN – Crestone Peak
   
7:00 AM–8:00 AM 2018 PROGRAM COMMITTEE MEETING – Mt. Princeton
   
7:00 AM–8:00 AM BREAKFAST WITH THE TERATOLOGY MENTORS – Mt. Oxford
(Advance Signup Is Required)
 

Chairpersons: Dana L. Shuey. Incyte and Dinesh J. Stanislaus, GlaxoSmithKline

   
7:30 AM–8:00 AM MORNING COFFEE AND PASTRIES – Aspen Foyer
(Joint with DNTS)
   
8:00 AM–9:00 AM KEYNOTE ADDRESS – Aspen Ballroom
(Joint with DNTS)
  Cannabis in Colorado: The Impact of Legalization on Children and Families (L2)
  Chairpersons: Alan M. Hoberman, Charles River Laboratories and Gregg D. Stanwood, Florida State University
  Larry I. Wolk, Colorado Department of Public Health and Environment
   
9:15 AM–12:00 Noon RSA/FASD-SG, TERATOLOGY SOCIETY, OTIS, AND DNTS EXCHANGE SYMPOSIUM – Aspen Ballroom
  (Joint with DNTS)
 

Evaluation of Fetal Risk in the Context of Multiple Co-Exposures

  Chairpersons: Ludmila Bakhireva, University of New Mexico and Jeffrey R. Wozniak, University of Minnesota
9:15 AM–9:25 AM   Introduction: Methodological Challenges of Evaluating the Effect of Multiple Exposures
    Ludmila Bakhireva, University of New Mexico
     
9:25 AM–9:50 AM S16

Defining the Human Exposome

    Cynthia F. Bearer, University of Maryland
     
9:50 AM–10:15 AM S17 PK/PD Modelling for Multiple Exposures in Pregnancy
    Donald R. Mattison, Risk Sciences International
     
10:15 AM–10:40 AM   Networking Break – Aspen Foyer
     
10:40 AM–11:05 AM S18 Alcohol and Nicotine-Induced Epigenetic Changes (miRNAs)
    Rajesh C. Miranda, Texas A&M Health Sciences Center
     
11:05 AM–11:30 AM S19 Epigenetic Changes Induced by Prenatal Nicotine and Cocaine Exposure
    Pradeep Bhide, Florida State University
     
11:30 AM–11:35 AM  

Concluding Remarks

    Jeffrey R. Wozniak, University of Minnesota
   

 

11:35 AM–12:00 Noon   Panel Discussion
   
9:05 AM–11:45 AM PLATFORM SESSION 2 – Colorado Ballroom B
  Mechanistic and Clinical Teratology
Chairpersons: John M. DeSesso and Amy L. Williams, Exponent, Inc.
 

Presenting author is underlined.

9:05 AM-9:15 AM   Introduction
     
9:15 AM-9:30 AM 11

Prediction of Developmental Toxicity Potential Dictated by In Vivo Exposures with a Biomarker-Based Human Pluripotent Stem Cell Assay
Palmer JA, Smith AM, Colwell MR, Smart BJ, Ludwig MA, Burrier RE, Donley ELR, Kirchner FR. Stemina Biomarker Discovery, Inc., Madison, WI, United States

   

 

9:30 AM-9:45 AM 12

DNA Hypermethylation in Tight Junction Pathway Is Associated with Neural Tube Defects: A Genome-Wide DNA Methylation Analysis
Ren A1,2, Wang LL1,2, Lin S1,2, Zhang J1,2, Tian T1,2, Huang Y1,2. 1Institute of Reproductive and Child Health, Peking University, Beijing, China, 2Ministry of Health Key Laboratory of Reproductive Health, Peking University, Beijing, China.

     
9:45 AM-10:00 AM 13

Toxicogenomic Profiling of BDE-47 Effects in Human Primary Villous Cytotrophoblasts
Robinson JF, Hamilton EG, Ona K, Puckett KA, Kapidzic M, Fisher SJ. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco, San Francisco, CA, United States.

     
10:00 AM-10:15 AM 14

Targeted Dnmt3a Deletion Ameliorates Maternal Diabetes-Induced DNA Hypermethylation and Neural Tube Defects
Yang P, Xu C, Yang P. University of Maryland School of Medicine, Baltimore, MD, United States.

     
10:15 AM-10:30 AM 15

VDR Regulates Skeleton Development through MiR-140-5p by Transcriptional Regulation
Luo W, Yang L, Dong Y, Kong J, Yuan Z, Zhao Q. Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

     
10:30 AM-10:45 AM   Break—Aspen Foyer
     
10:45 AM-11:00 AM 16

Biliary Atresia and Maternal Nutrient Intake
Carmichael SL1, Ma C1, Van Zutphen A2,3, Moore CA4, Shaw GM1. 1Division of Neonatology and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States, 2Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, NY, United States, 3Department of Epidemiology and Biostatistics, University at Albany School of Public Health, Rensselaer, NY, United States, 4National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States.

     
11:00 AM-11:15 AM 17

Challenges of Species Selection for Development and Reproductive Toxicity Studies with A Dopamine Agonist
Zhuang Q, Rasmussen AD, Jensen KG, Bernholm K, Northeved H. Nonclinical Safety Research, H. Lundbeck A/S, Copenhagen, Denmark.

   

 

11:15 AM-11:30 AM 18

Justifying Mandatory Food Fortification with Folic Acid: Benefits Beyond Preventing Neural Tube Defects
Mills JL. Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, United States.

     
11:30 AM-11:45 AM 19

An Evaluation of Household Environments and Zika Risk Perceptions, Prevention Behaviors, and Prevention Knowledge among Pregnant Women in Puerto Rico
Turay KR1, Earle-Richardson G1, Medina-Martínez G2, Romero-Pérez M2, Chavez P3, Vega MC5, Thomas D4,5, Rivera-Garcia B5, Prue C1. 1Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Atlanta, GA, United States, 2Caduceus Staffing, Atlanta, GA, United States, 3Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA, United States, 4Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response, Atlanta, GA, United States, 5Puerto Rico Department of Health, San Juan, PR, United States.

   
12:00 Noon–1:30 PM LUNCH ON YOUR OWN
   
12:00 Noon–1:30 PM PAST PRESIDENTS' AND HONOREES' LUNCHEON – Maroon Peak
  (By Invitation Only)
   
12:00 Noon–1:30 PM MEMBERSHIP COMMITTEE MEETING – Mt. Yale
   
12:00 Noon–1:30 PM PUBLIC AFFAIRS COMMITTEE MEETING – Mt. Princeton
   
1:30 PM–4:50 PM MARCH OF DIMES SYMPOSIUM – Aspen Ballroom
The Complexities of Caring for the Pregnant and Lactating Patient with Chronic Inflammatory Disease: Maternal and Fetal Considerations
(Joint with OTIS)
  Chairpersons: Christina D. Chambers, University of California-San Diego and Melissa S. Tassinari, Independent Consultant
1:30 PM–1:35 PM   Introduction
     
1:35 PM–1:55 PM S20 Overview: Complexity of Disease Management in Pregnancy and Lactation, Consequences of Chronic Disease Itself and Polypharmacy, Use of Asthma and Lupus As Examples
    Megan E.B. Clowse, Duke University
     
1:55 PM–2:15 PM S21 Case Study: Asthma in Pregnancy
    Jennifer A. Namazy, Scripps Clinic Mission Valley
     
2:15 PM–2:35 PM S22 Case Study: Lupus in Pregnancy
    Megan E.B. Clowse, Duke University
     
2:35 PM–2:55 PM S23 Missing Data
    Christine Stallman, University of Arizona and MotherToBaby Arizona
     
2:55 PM–3:15 PM S24 Long Term Effects of Maternal Factors on Child’s Risk for Autism and Other Neurodevelopmental Concerns
   

Irva Hertz-Picciotto, University of California-Davis

     
3:15 PM–3:35 PM S25 Chronic Maternal Immune Mediated Diseases and Their Treatments: How Do We Design Good Quality Studies to Evaluate Neurodevelopment in the Offspring?
   

Gail S. Ross, Cornell University

     
3:35 PM–3:50 PM   Break - Aspen Foyer
     
3:50 PM–4:10 PM S26 Lactation and Medications
    Philip O. Anderson, University of California-San Diego
     
4:10 PM–4:30 PM S27 Pregnancy and Lactation Labeling Rule (PLLR): Placement of Human Data in Labeling
   

Tamara Johnson, US Food and Drug Administration

     
4:30 PM–4:50 PM   Panel Discussion
   
1:30 PM–5:30 PM MALE BREAST HEALTH: THE ROLE OF DEVELOPMENTAL EXPOSURES ON CHILDHOOD AND ADULT OUTCOMES SYMPOSIUM – Colorado Ballroom A
  Chairpersons: Susan Y. Euling, US Environmental Protection Agency and Suzanne E. Fenton, National Institute of Environmental Health Sciences
1:30 PM–2:15 PM S28 Species Differences in Mammary Gland Development and Susceptibility to Environmental Chemicals: Human–Animal Species Comparisons
    Ana M. Soto, Tufts University
     
2:15 PM–2:55 PM S29 Male Rat Mammary Gland Effects after Developmental Exposure to Environmental Chemicals
    Suzanne E. Fenton, National Institute of Environmental Health Sciences
     
2:55 PM–3:35 PM S30 Genesis of Male Breast Cancer: An Epidemiologic Perspective
    Louise A. Brinton, Division of Cancer Epidemiology and Genetics, NCI
     
3:35 PM–3:50 PM   Break – Aspen Foyer
     
3:50 PM–4:30 PM S31 The Role of Environmental Factors in Pubertal Gynecomastia
    Susan Y. Euling, US Environmental Protection Agency
     
4:30 PM–5:10 PM S32 The Development of Pubertal Gynecomastia and the Association to Endogenous Hormones, Growth, and Body Composition
    Mikkel G. Mieritz, Rigshospitalet
     
5:10 PM–5:30 PM   Discussion
   
5:30 PM–7:30 PM POSTER SESSION 1 AND EXHIBITS ATTENDED – Capitol Peak Ballroom
(Joint with DNTS and OTIS)
 

Teratology Society Posters P1–P14
DNTS Posters 1-21
OTIS Posters 1–14

P1        Overview of Zika en Embarazadas y Niños en Colombia (ZEN): A Prospective Cohort Study Examining Zika Virus Infection during Pregnancy and Risk of Adverse Pregnancy, Birth, and Infant Outcomes
Colombian Instituto Nacional de Salud1, US Centers for Disease Control and Prevention2, Anderson KN2. 1Colombian Instituto Nacional de Salud, Bogota, Colombia, 2US Centers for Disease Control and Prevention, Atlanta, GA, United States.

P2        Assessing Teratogenicity from the Clustering of Abnormal Phenotypes in Individual Zebrafish Larvae
Ali S2, Aalders J1, Jong T1, Richardson M1. 1Sylvius Laboratory, Institute of Biology, Leiden University, Leiden, The Netherlands, 2Department of Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.

P3        Quantitative Prediction of Microcephaly Utilizing Cell Agent-Based Modeling: Profiling the Centrosome Cycle
Zurlinden TJ1, Saili KS1, Spencer RS2, Baker NC2, Knudsen TB1. 1National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United States, 2Leidos, Research Triangle Park, NC, United States.

P4        Computational Modeling of the Neurovascular Unit to Predict Microglia Mediated Effects on Blood-Brain Barrier Formation
Zurlinden TJ1, Saili KS1, Spencer RS2, Baker NC2, Knudsen TB1. 1National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United States, 2Leidos, Research Triangle Park, NC, United States.

P5        Cardiovascular Ultrasound of Neonatal Long Evans Rats Exposed Prenatally to Trichloroacetic Acid: Effects on Heart Rate, Ejection Fraction, and Cardiac Output
Narotsky MG1, Thompson LC2, Manley AL3, Ola O4. 1Toxicity Assessment Division, ORD, US Environmental Protection Agency, Research Triangle Park, NC, United States, 2Environmental & Public Health Division, US Environmental Protection Agency, Research Triangle Park, NC, United States, 3Oak Ridge Institute for Science and Education, US Environmental Protection Agency, Research Triangle Park, NC, United States, 4Student Contractor, US Environmental Protection Agency, Research Triangle Park, NC, United States.

P6        Hazard Screening Approaches for Identifying Developmental and Reproductive Toxicity in the Workplace
Pacheco Shubin SE
1, Cohen JM2, Dodge DG3, Lewandowski TA1. 1Gradient, Seattle, WA, United States, 2Gradient, Cambridge, MA, United States, 3Gradient, Bend, OR, United States.

P7        Systems Toxicology Model of Neurovascular Development
Saili KS1, Zurlinden TJ1, Baker NC2, Knudsen TB1. 1National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United States, 2Leidos, Research Triangle Park, NC, United States.

P8        Orofacial Clefting in Response to Hedghog Pathway Antagonists is Recapitulated in a Practical Epithelial–Mesenchymal 3D Culture Model
Johnson BP2, Vitek RM2, Fink DM1, Chung H1, Geiger P2, Beebe DJ2, Lipinski RJ1. 1University of Wisconsin, Department of Comparative Biosciences, Madison, WI, United States, 2University of Wisconsin, Department of Biomedical Engineering, Madison, WI, United States.

P9        Developmental Neurotoxicity after Exposure to Pesticides: Adding a Biotransformation Component Impacts the Pathways Affected in Human Neural Progenitor Cells (hN2)
McKenzie EM1, Amosu OM1, Smith MA1, Stice SL1,2. 1University of Georgia, Athens, GA, United States, 2ArunA Biomedical, Inc, Athens, GA, United States.

P10      Characterizing the Effect of Embryonic Ethanol Exposure on Cranial Nerve Development in Zebrafish Embryos Mutant for the Ethanol-Sensitive Allele, vangl2
Buckley DM
, Eberhart JK. University of Texas–Austin, Austin, TX, United States.

P11      The Effects of Quaternary Ammonium Compounds on Development of the Microbiome
McDonald VA1, Hrubec TC2. 1Department Biological Sciences, VA Tech, Blacksburg, VA, United States, 2E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States.

P12      Abundance of Household Products Contain Quaternary Ammonium Compounds
Hrubec TC1,2, DiPeppi R1. 1E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States, 2VA-MD College of Veterinary Medicine, Blacksburg, VA, United States.

P13      Follow the White Rabbit: Does the Source of Time-Mated New Zealand White Rabbits Impact Maternal or Developmental Parameters?
Olitan TA
, Rayhon SL, McNerney ME, Thompson KE. Bristol-Myers Squibb, New Brunswick, NJ, United States.

P14      A Comparison of the Embryofetal Development Data Collected from New Zealand White (Crl:KBL[NZW]) Rabbits at Several Teratology Laboratories
Pouliot L1, Marsden E2, Lewis EM3, Robinson K1. 1Charles River, Montréal, QC, Canada, 2Charles River, Lyon, France, 3Charles River, Horsham, PA, United States.

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7:30 PM–10:00 PM TERATOLOGY SOCIETY AND
MARTA STUDENT CAREER EVENT
– Mt. Sopris
(Open to Teratology Society, DNTS, and OTIS Student and Postdoctoral Fellows)

Tuesday, June 27, 2017
7:00 AM–6:00 PM REGISTRATION OPEN – Aspen Foyer
   
7:00 AM–8:00 AM COMMUNICATIONS WORKING GROUP AND WEBSITE COMMITTEE MEETING – Mt. Princeton
   
7:00 AM–6:00 PM SPEAKER READY ROOM OPEN – Crestone Peak
   
7:30 AM–8:00 AM MORNING COFFEE AND PASTRIES – Aspen Foyer
(Joint with DNTS)
   
8:00 AM–9:00 AM ROBERT L. BRENT LECTURE - TERATOGEN UPDATE – Aspen Ballroom
(Joint with OTIS)
 

In Bed wIth the Devil: Recognizing Human Teratogenic Exposures (L3)

  Chairperson: Sonja A. Rasmussen, Centers for Disease Control and Prevention
  Speaker: Jan M. Friedman, University of British Columbia
   
9:05 AM–12:30 PM PUBLIC AFFAIRS SYMPOSIUM – Aspen Ballroom
(Joint with DNTS)
  The Toxicology of Tobacco Smoke and E-Cigarette Use during Pregnancy
  Chairpersons: Ludmila Bakhireva, University of New Mexico and John M. Rogers, US Environmental Protection Agency
9:05 AM–9:15 AM   Introduction
     
9:15 AM–9:55 AM S33 Tobacco As a Reproductive and Developmental Toxicant
    John M. Rogers, US Environmental Protection Agency
     
9:55 AM–10:35 AM S34 E-Cigarettes: What are They, What Do They Do, and What Are Potential Impacts on Pregnancy Outcomes?
    Alison Breland, Virginia Commonwealth University
     
10:35 AM–10:50 AM   Break
     
10:50 AM–11:30 AM S35 The Role of Nicotine in the Effects of Maternal Smoking during Pregnancy on Lung Development and Childhood Respiratory Disease
    Virender K. Rehan, University of California, Los Angeles
     
11:30 AM–12:10 PM S36 Neurodevelopmental Toxicity of Tobacco Smoke and Nicotine
    Edward D. Levin, Duke University
     
12:10 PM–12:30 PM   Discussion
   
9:05 AM–12:30 PM GLOBAL BURDEN OF DISEASE: MORTALITY AND SURVIVAL IN INFANTS BORN WITH BIRTH DEFECTS SYMPOSIUM – Colorado Ballroom B
  (Joint with National Birth Defects Prevention Network)
  Chairpersons: Russell Kirby, University of South Florida and Godfrey P. Oakley Jr., Emory University
9:05 AM–9:20 AM S37 Introduction: Why Study Outcomes of Children with Birth Defects?
    Russell Kirby, University of South Florida
     
9:20 AM–9:45 AM S38 Infant and Child Mortality Outcomes for Children with Trisomies
    Russell Kirby, University of South Florida
     
9:45 AM–10:10 AM S39 Perinatal Mortality in the Context of Spina Bifida
    Nelson Pace, University of North Carolina–Chapel Hill
     
10:10 AM–10:35 AM S40 Achieving Reductions in Child Mortality by Preventing Birth Defects in India and Reaching Sustainable Development Goals
    Vijaya Kancherla, Emory University
     
10:35 AM–10:50 AM   Break – Aspen Foyer
     
10:50 AM–11:15 AM S41 Reducing the Global Burden of Disease Associated with Birth Defects
    Robert.J. Berry, Emory University
     
11:15 AM–11:35 AM   Concluding Remarks
    Godfrey P. Oakley Jr., Emory University
     
11:35 AM–12:30 PM   Discussion
   
12:30 PM–2:30 PM LUNCH AND LEARN MINICOURSE – Mt. Columbia
  Epidemiology: Basic Concepts, Study Designs, and Practical Applications
  (Separate Registration Required)
  Organized by the Education Committee, Chairperson, Kimberly C. Brannen, Merck
12:30 PM–1:15 PM Basic Concepts and Methodology
  Peter Langlois, Texas Department of State Health Services
   
1:15 PM–2:00 PM The Significance of Significance Testing and Its Application to the Epidemiology of Rare Outcomes
  Sarah C. Tinker, Centers for Disease Control and Prevention
   
12:30 PM–2:30 PM LUNCH ON YOUR OWN
   
2:30 PM–3:00 PM AGNISH FELLOWSHIP LECTURE – Aspen Ballroom
  Why and How We Must Be Lifelong Educators-Even if It’s Not in Our Job Titles
  Chairperson: Kimberly C. Brannen, Merck
  Lecturer: Elaine Z. Francis, Sandcastle Toxicology Associates
   
3:05 PM–5:30 PM MARIJUANA AND CHILD DEVELOPMENT SYMPOSIUM – Aspen Ballroom
  (Joint with DNTS and OTIS)
  Chairpersons: Diana Dow-Edwards, SUNY/Downstate Medical Center and Susan L. Makris, US Environmental Protection Agency
3:05 PM-3:10 PM   Introduction
    Diana Dow-Edwards, SUNY/Health Science Center
     
3:10 PM-3:35 PM S42 Dynamic Changes in Endocannabinoid Signaling During Adolescence: Implications for Substance Use and Psychopathology
   

BJ Casey, Yale University

     
3:35 PM-4:00 PM S43 Counseling Women About Prenatal Marijuana Use: Weeding through the Data
    Torri D. Metz, University of Colorado-Denver
     
4:00 PM-4:15 PM   Break
     
4:15 PM-4:40 PM S44 Cannabis and the Adolescent Brain: What Does the Evidence Say?
   

Joanna Jacobus, University of California-San Diego

     
4:40 PM-5:05 PM S45

Cannabinoids for Treatment of Pediatric Epilepsy: The Hype and the Evidence

   

Amy R. Brooks-Kayal, University of Colorado-Denver

     
5:05 PM-5:30 PM S46 Cannabis Policy: Challenges and Future Directions
   

Susan R. B. Weiss, National Institute on Drug Abuse

   
3:05 PM–5:30 PM THE USES OF CRISPR/Cas9 TECHNOLOGY WORKSHOP – Colorado Ballroom A
  Chairperson: Alan M. Hoberman, Charles River Laboratories
3:05 PM-3:15 PM   Introduction
    Alan M. Hoberman, Charles River Laboratories
     
3:15 PM-4:00 PM W3 CRISPR-Cas9: From Mechanism to Therapy
    Jacob Corn, University of California-Berkeley
    Learning Objectives: Attendees will learn about advances in next-generation genome editing with applications to the cure of human genetic disease
     
4:00 PM-4:15 PM   Break
     
4:15 PM-5:00 PM W4 The Ethical Implications of CRISPR-Cas9
   

Krishanu Saha, University of Wisconsin-Madison

     
5:00 PM-5:30 PM   Discussion
   
5:30 PM–7:30 PM POSTER SESSION 2 AND EXHIBITS ATTENDED – Capitol Peak Ballroom
 

Teratology Society Posters P15–P43

P15      Zika Related Birth Defect Surveillance in Missouri
Wambuguh L, Garrett L, Sapkota A, McCarthy E. Missouri Department of Health and Senior Services, Bureau of Vital Statistics, Jefferson City, MO, United States.

P16      An Evaluation of the New Zealand White Rabbit Model for Zika Virus Infection during Gestation and Microcephaly in the Offspring
O'Hara MF
1, Ramachandra R2. 1Covance Drug Development, Greenfield, IN, United States, 2Covance Immunology Services, Denver, PA, United States.

P17      Behavioral Screening of the LOPAC1280 Library Reveals that Zebrafish Embryos are Unable to Discriminate Modes of Action for Neuroactive Compounds
Vliet SM1,2, Ho TC2, Volz DC2. 1Environmental Toxicology Graduate Program, University of California–Riverside, Riverside, CA, United States, 2Department of Environmental Sciences, University of California–Riverside, Riverside, CA, United States.

P18      Evaluation of Maternal Transplacental Transfer of Anti-F-Antibodies to Pups Following Immunization of Pregnant Hartley Guinea Pigs with a Recombinant Respiratory Syncytial Virus Vaccine
Murphy CJ, Goodnight SY, Murphy L, Godin CS. Smithers Avanza, Gaithersburg, MD, United States.

P19      Maternal Diabetes Suppresses Mitochondrial Fusion Leading to Heart Defects through the miR-195-Mitofusin 1/Mitofusin 2 Circuit
Zhong J, Yang P. University of Maryland School of Medicine, Baltimore, MD, United States.

P20      The Development of Type 2 Diabetes in Nonobese Male Swiss-Webster Mice: Effect of Exposure to a Gluten-Free Diet
Kepko DS1, Wells C1, Boornazian A2, Gosstola N2, Smith H2, Wing B2, Munagala A2, Thigpen H2, Rasco JF2, Bailey MM1. 1Emporia State University, Emporia, KS, United States, 2University of Alabama, Tuscaloosa, AL, United States.

P21      Survival of Infants with Spina Bifida and the Role of Maternal Pre-Pregnancy Body Mass Index
Pace ND1, Siega-Riz AM1, Olshan AF1, Chescheir NC2, Cole SR1, Desrosier TA1, Tinker SC3, Hoyt AT4, Canfield MA4, Carmichael SL5, Meyer RE6, The National Birth Defects Prevention Study3. 1Department of Epidemiology, University of North Carolina–Chapel Hill, Chapel Hill, NC, United States, 2Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina–Chapel Hill, Chapel Hill, NC, United States, 3National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States, 4Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States, 5Department of Pediatrics, Division of Neonatology and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, United States, 6Birth Defects Monitoring Program, North Carolina Department of Health and Human Services, Raleigh, NC, United States.

P22      Computational Toxicology and Computational Modeling of Embryonic Limb Development Using ToxCast High-Throughput Screening Data
Ahir B1, Spencer R2, Baker N2, Judson R3, Martin M3, Knudsen T3. 1University of Illinois College of Medicine at Chicago, Chicago, IL, United States, 2Lockheed Martin, US EPA, Research Triangle Park, NC, United States, 3National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United States.

P23      A 3D Organotypic Human Stem Cell Model to Evaluate Human Palatal Fusion
Wolf CJ, Belair DG, Becker CM, Abbott BD. US Environmental Protection Agency, Research Triangle Park, NC, United States.

P24      Assessment of Developmental Toxicity Potential of Glyphosate-Based Herbicides Using Drosophila melanogaster Primary Embryonic Stem Cell Cultures
Argueta JA, Torres A. California State University–San Bernardino, San Bernardino, CA, United States.

P25      Behavioral Profiling of Zebrafish Embryos Exposed to a Panel of Sixty Water-Soluble Compounds
Ali S1, Champagne D2, Richardson M2. 1Department of Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan, 2Sylvius Laboratory, Institute of Biology, Leiden University, Leiden, The Netherlands.

P26      Teratological Effects of a Panel of Sixty Water-Soluble Toxicants on Zebrafish Development
Ali S
1, Aalders J2, Richardson M2. 1Department of Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan, 2Sylvius Laboratory, Institute of Biology, Leiden University, Leiden, The Netherlands.

P27      Developmental Toxicity of Leucomalachite Green on Zebrafish
Wan H
, Zhang H. Guangdong Zhongke EnHealth Technology Co., Ltd., Foshan, China.

P28      Effect of Neonatal Abstinence Syndrome on Neurodevelopmental Outcomes at Six Months of Age in Infants Born to Women on Medication-Assisted Treatment for Opioid Use Disorder
Ashley M, Holbrook BD, Cano S, Lowe J, Stephen JM, Qeadan F, Leyva Y, Rayburn W, Leeman L, Bakhireva L. University of New Mexico Health Sciences Center, Albuquerque, NM, United States.

P29      Developmental Toxicity of Dimethadione and Acetylsalicylic Acid in Rats
Toy H1, Harris SB2, Mylchreest E1. 1Battelle, West Jefferson, OH, United States, 2Stephen B. Harris Group, San Diego, CA, United States.

P30      Exposure to QACs Alters Inflammatory Responses in Murine Macrophages
Nguyen HD1, McDonald VA2, Hrubec TC1,3. 1E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States, 2Department Biological Sciences, Virginia Tech, Blacksburg, VA, United States, 3VA-MD College of Veterinary Medicine, Blacksburg, VA, United States.

P31      Validation of and Disparities with Prevalence of Congenital Microcephaly: New York State 2013–2015
Fox D1, Brady L1, Pantea C1, Graham K2, Talati A2, Browne M1, Carter S3, Friedenberg E3, Vora N3,4, Lee C3,5. 1Congenital Malformations Registry, New York State Department of Health, Albany, NY, United States, 2Public Health/Preventive Medicine Residency Program, New York City Department of Health and Mental Hygiene, New York City, NY, United States, 3Division of Disease Control, New York City Department of Health and Mental Hygiene, New York City, NY, United States, 4Office of Public Health Preparedness and Response, CDC, New York City, NY, United States, 5Epidemic Intelligence Service, CDC, New York City, NY, United States.

P32      Sex and Dose-Related Differences in Behavior Following Excess Taurine Consumption by B6 Mice during Adolescence and Early Adulthood
Villalona YE, Weimer JL, Massie LA, Marczinski CA, Curran CP. Northern Kentucky University, Highland Heights, KY, United States.

P33      From Inhibition of Retinoic Acid Catabolism to Facial Malformations: Suggestions for a New Adverse Outcome Pathway
Di Renzo F1, Moretto A1,2, Eberini I1, Beronius A3, Zilliacus J3, Hanberg A3, Menegola E1. 1Università degli Studi di Milano, Milan, Italy, 2ICPS ASST Fatebenefratelli Sacco, Milan, Italy, 3Karolinska Instituted, Stockholm, Sweden.

P34      In Vitro Embryo Exposure to Retinoic Acid, Valproic Acid, Ethanol, and to the Antifungal Prochloraz Alone or in Mixture: Effects on Cranio-Facial Morphogenesis
Menegola E1, Bacchetta R1, Battistoni M1, Di Renzo F1, Metruccio F2, Moretto A1,2. 1Università degli Studi di Milano, Milan, Italy, 2ICPS ASST Fatebenefratelli Sacco, Milan, Italy.

P35      Inflammogenic and Vascular Effects of Acute Pulmonary Exposure to Titanium Dioxide Nanoparticles
Abukabda AB
, McBride CR, Nurkiewicz TR. West Virginia University, Morgantown, WV, United States.

P36      Battery of Reproductive Toxicology Studies Supporting the Safety of a Dopamine Receptor Antagonist, Molindone
Krishna G
1, Gopalakrishnan G1, Yu C1, Ganiger S2, White T3. 1Supernus Pharmaceuticals, Inc., Rockville, MD, United States, 2Advinus Therapeutics Ltd., Bengaluru, Karnataka, India, 3Aclairo Pharmaceutical Development Group, Inc., Vienna, VA, United States.

P37      Intersecting Principles of Teratology and Toxicology in Nursing Education and Community Engagement
Dodd-Butera T1, Shaputnic C2. 1California State University, San Bernardino, CA, United States, 2University of California Institute for Fetal Alcohol Spectrum Disorders Discovery, San Diego, CA, United States.

P38      Effects of Quaternary Ammonium Compounds on Neural Stem/Progenitor Cells
Meade HA1, Shea CS2, Hrubec TC2,3. 1Department of Biochemistry, Virginia Tech, Blacksburg, VA, United States, 2E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States, 3VA-MD College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.

P39      Ontogeny of the Central Nervous System across Species
Williams AL1, DeSesso JM1,2. 1Exponent, Inc., Alexandria, VA, United States, 2Georgetown University School of Medicine, Washington, DC, United States.

P40      Alcohol Exacerbates the Teratogenic Effects of Prenatal Cannabinoid Exposure in a C57BL/6J Mouse Model
Fish EW1, Boschen KE1, Murdaugh LB1, Mendoza-Romero HN1, Williams KP2, Parnell SE1. 1University of North Carolina, Chapel Hill, NC, United States, 2North Carolina Central University, Durham, NC, United States.

P41      Evaluation of Ad Libitum Feeding in Pregnant Rabbits
Rayhon SL, Seethala RK, McNerney ME, Thompson KE. Bristol-Myers Squibb Company, New Brunswick, NJ, United States.

P42      Ocular Evaluations in Juvenile Dutch Belted Rabbits
Robinson KJ, Martin AI, Pouliot L, Vezina M. Charles River, Montréal, QC, Canada.

P43      Post Natal Cardiovascular Assessment in Juvenile Beagle Dogs Using Telemetry
Adamo M, Primakova I, Kirouac A, Norton K, Robinson K. Charles River, Montréal, QC, Canada.

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Wednesday, June 28, 2017
6:30 AM–7:30 AM TERATOLOGY SOCIETY 36TH ANNUAL VOLLEYBALL GAME – Benedict Fountain Park
   
7:30 AM–8:30 AM BDR EDITORIAL BOARD MEETING - Mt. Wilson
   
7:30 AM–8:30 AM EDUCATION COMMITTEE MEETING – Mt. Princeton
   
7:30 AM–8:30 AM NOMINATION AND ELECTIONS COMMITTEE MEETING – Mt. Yale
   
7:30 AM–2:30 PM REGISTRATION OPEN – Aspen Foyer
   
7:30 AM–2:30 PM SPEAKER READY ROOM OPEN – Crestone Peak
   
8:00 AM–8:30 AM MORNING COFFEE AND PASTRIES – Aspen Foyer
(Joint with DNTS)
   
8:30 AM–9:30 AM TERATOLOGY SOCIETY AND EUROPEAN TERATOLOGY SOCIETY EXCHANGE LECTURE – Aspen Ballroom
 

Morphological Variations in Animal Studies: Useful for Human Risk Assessment or a Red Herring? (L4)

  Chairpersons: Susan L. Makris, US Environmental Protection Agency and Manon Beekhuijzen, Charles River
 

European Teratology Society
Paul C. Barrow, F. Hoffmann-La Roche Ltd.

 

Teratology Society
Christopher J. Bowman, Pfizer Inc.

   
9:35 AM–12:30 PM AN UPDATE ON THE ZIKA VIRUS SYMPOSIUM – Aspen Ballroom
(Joint with DNTS)
  Chairpersons: José F. Cordero, University of Georgia and Sonja A. Rasmussen, Centers for Disease Control and Prevention
9:35 AM–9:50 AM   Introduction
    Chairpersons: José F. Cordero, University of Georgia and Sonja A. Rasmussen, Centers for Disease Control and Prevention
     
9:50 AM–10:25 AM S47 The Zika Epidemic: An Update from the CDC
    Margaret Honein, Centers for Disease Control and Prevention
     
10:25 AM–11:00 AM S48 Neurobehavioral Aspects of Zika Virus
   

Vanessa Van den Linden, Assistance Association for Disabled Children

     
11:00 AM–11:30 AM   Warkany Tea
     
11:30 AM–12:05 PM S49 Zika Infection: From Basic Science to Treatment
    Alysson Renato Muotri, University of California-San Diego
     
12:05 PM–12:30 PM   Panel Discussion
   
11:00 AM–11:30 AM WARKANY TEA – Aspen Foyer
(Joint with DNTS)
   
12:30 PM–1:30 PM AWARDS COMMITTEE MEETING - Mt. Yale
   
12:30 PM–1:30 PM LUNCH ON YOUR OWN
   
1:30 PM–4:30 PM FROM FRONT PAGE TO THE DIGITAL STAGE: HOW TO KEEP RESEARCH RELEVANT THROUGH MODERN MEDIA WORKSHOP (W5) – Colorado Ballroom A
  Chairperson: Christine Perdan Curran, Northern Kentucky University
1:30 PM-1:50 PM Federation of American Societies for Experimental Biology's Approach to Science Policy Challenges: Getting Our Message Out
  Hudson Freeze, Federation of American Societies for Experimental Biology
   
1:50 PM-2:10 PM Working Effectively with Science Journalists: From Deadline Reporting to In-Depth Coverage
  Elena Conis, University of California-Berkeley
   
2:10 PM-2:30 PM News Versus Advocacy: Why Zika Is a Hot Story and Folic Acid Is Not
  Helen Branswell, STAT News
   
2:30 PM-2:50 PM An Industry Perspective on Science Communication
  Donna R. Farmer, Monsanto Company
   
2:50 PM-3:15 PM Effectively Using Images and Video in Scientific Communication
  Christine Perdan Curran, Northern Kentucky University
   
3:15 PM-3:30 PM Break
   
3:30 PM-4:30 PM Panel Discussion
 

Moderator: Nicole Chavez, Communications Consultant

   
1:30 PM–4:30 PM ILSI HESI WORKSHOP – Aspen Ballroom
 

Redesigning the Embryofetal Developmental Toxicity Study: Evolution or Revolution?

  Chairpersons: George P. Daston, Procter & Gamble Company and Anthony R. Scialli, Scialli Consulting LLC
1:30 PM–2:00 PM W6 Hypothesis-Driven Approaches for Assessing Developmental Toxicity
    George P. Daston, Procter & Gamble Company
     
2:00 PM–2:30 PM W7 In Vitro Data and In Silico Models for Computational Toxicology
    Thomas B. Knudsen, National Center for Computational Toxicology, US EPA
     
2:30 PM–3:15 PM W8 Redesigning the Embryofetal Developmental Toxicity Study: Revolution–Changing the Approach
    Aldert Piersma, RIVM
     
3:15 PM–3:30 PM   Break
     
3:30 PM–3:45 PM W9 Improving Dose-Response Assessment in Developmental Toxicity Testing and Risk Assessment
    Sue Makris, US Environmental Protection Agency
     
3:45 PM–4:00 PM W10 Humanized Experimental Models
    Alan Hoberman, Charles River Laboratories
     
4:00 PM–4:15 PM W11 Models of Animal Disease
    Kary E. Thompson, Bristol-Myers Squibb and Pragati Sawhney Coder, Charles River Ashland
     
4:15 PM–4:30 PM   Discussion
   
1:30 PM–4:30 PM PLATFORM SESSION 3 – Colorado Ballroom B
 

Clinical Teratology

  Chairpersons: Jeffrey H. Charlap, Charles River Laboratories and Pragati Sawhney Coder, Charles River Ashland
1:30 PM–1:45 PM   Introduction
     
1:45 PM–2:00 PM 21

Fine Mapping for Genetic Susceptibility to Valproic Acid-Induced Exencephaly in Mice
Lei Y, Wlodarczyk BJ, Cabrera RM, Finnell RH. Dell Medical School, Austin, TX, United States.

     
2:00 PM–2:15 PM 22

In Utero Exposure to the Pesticide Synergist and Sonic Hedgehog Signaling Inhibitor Piperonyl Butoxide Causes Holoprosencephaly in Mice
Everson JL, Lipinski RJ. University of Wisconsin–Madison, Madison, WI, United States.

     
2:15 PM–2:30 PM 23

Gene-Environment Interactions in Holoprosencephaly
Muenke M1, Kruszka P1, Addissie Y1, Troia A2, Kozel B2, Everson J3, Malecki K4, Lipinski R3.
1National Human Genome Research Institute, NIH, Bethesda, MD, United States, 2National Heart, Lung, and Blood Institute, NIH, Bethesda, MD, United States, 3Department of Comparative Biosciences, Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States, 4Department of Population Health Sciences, School of Medicine and Public Health, University of Wisconsin, Madison, WI, United States.

     
2:30 PM–2:45 PM 24

Hypospadias, Intrauterine Growth Restriction, and Abnormalities of the Placenta
Toufaily MH1, Roberts D2, Westgate M-N1, Hunt A-T3, Holmes LB1. 1MassGeneral Hospital for Children, Boston, MA, United States, 2Massachusetts General Hospital, Boston, MA, United States, 3Hunt Consulting Associates, Chapel Hill, NC, United States.

     
2:45 PM–3:00 PM 25

Changes in Serum Lipid Profiles in Neonatal Monkeys Associated with Sevoflurane-Induced Neurotoxicity
Slikker W1, Wang C2, Han X2, Liu F1, Gu Q1, Liu S1, Patterson T1, Paule M1, Hanig J3, Wang C1. 1National Center for Toxicological Research, US FDA, Jefferson, AR, United States, 2Center for Metabolic Origins of Disease, Sanford Burnham Prebys Medical Discovery Institute at Lake Nona, Orlando, FL, United States, 3Center for Drug Evaluation and Research, US FDA, Silver Spring, MD, United States.

     
3:15 PM–3:30 PM 26

Maternal Antihypertensive Medication Use and Selected Birth Defects in the National Birth Defects Prevention Study
Fisher SC1, Van Zutphen AR1,2, Werler MM3, Romitti PA4, Cunniff CM5. 1Congenital Malformations Registry, New York State Department of Health, Albany, NY, United States, 2Department of Epidemiology and Biostatistics, School of Public Health, University at Albany, Rensselaer, NY, United States, 3Department of Epidemiology, School of Public Health, Boston University, Boston, MA, United States, 4Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, United States, 5Department of Pediatrics, Weill Cornell Medical College, New York, NY, United States.

     
3:30 PM–3:45 PM 27

A Mysterious Story of Embryo-Foetal Developmental Toxicity in Rats with AX
Zhuang Q, Rasmussen AD, Bernholm K, Northeved H. Nonclinical Safety Research, H. Lundbeck A/S, Copenhagen, Denmark.

     
3:45 PM–4:00 PM 28

Birth Outcomes following Pregnancy Exposure to Adalimumab: The OTIS Autoimmune Diseases in Pregnancy Project
Chambers CD1, Johnson DL1, Xu R1, Luo Y1, Adam MP2, Braddock SR3, Robinson L4, Vaux K1, Jones KL1, The OTIS Collaborative Research Group1. 1University of California–San Diego, La Jolla, CA, United States, 2University of Washington, Seattle, WA, United States, 3Saint Louis University, St. Louis, MO, United States, 4University at Buffalo, Buffalo, NY, United States.

     
4:00 PM–4:15 PM 29

Birth Defect Surveillance As a Requirement for Reducing Birth Defects in a Developing Country
Fakoya FA1, Wade A2. 1St. George's University II, Newcastle Upon Tyne, United Kingdom, 2St. George's University, St. George's, Grenada.

     
4:15 PM–4:30 PM 30

Clinical Variability of the Congenital Zika Syndrome
Del Campo M1, Feitosa IML2, Garcia-Alix A3, Schuler-Faccini L2. 1University of California–San Diego, San Diego, CA, United States, 2Universidade Federal de Rio Grande do Sul, Porto Alegre, RGDS, Brazil, 3Institut de Recerca Pediatrica Hospital Sant Joan de Deu, Barcelona, Catalunya, Spain.

   
4:30 PM–6:00 PM BUSINESS MEETING – Aspen Ballroom
   
6:30 PM–7:30 PM BANQUET RECEPTION – Capitol Peak Ballroom Foyer
   
7:30 PM–11:00 PM BANQUET – Capitol Peak Ballroom

Travel Awards

James C. Bradford Memorial Student Poster Awards

Wilson Presentation Awards

Marie W. Taubeneck Award

Edward W. Carney Trainee Award

Birth Defects Research Distinguished Scholar Awards

Edward W. Carney Distinguished Service Award

Recognition of Other Awards Presented throughout the Week


Thursday, June 29, 2017
7:00 AM–10:00 AM COUNCIL 2 MEETING – Mt. Columbia
   


Monday, March 20, 2017; at 11:33:57 AM EDT
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