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Annual Meeting 2017

Meeting Program

(Information is subject to change.)

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Tuesday, June 27, 2017
7:00 AM–6:00 PM REGISTRATION OPEN – Aspen Foyer
   
7:00 AM–8:00 AM COMMUNICATIONS WORKING GROUP AND WEBSITE COMMITTEE MEETING – Mt. Princeton
   
7:00 AM–6:00 PM SPEAKER READY ROOM OPEN – Crestone Peak
   
7:30 AM–8:00 AM MORNING COFFEE AND PASTRIES – Aspen Foyer
(Joint with DNTS)
   
8:00 AM–9:00 AM ROBERT L. BRENT LECTURE - TERATOGEN UPDATE – Aspen Ballroom
(Joint with OTIS)
 

In Bed wIth the Devil: Recognizing Human Teratogenic Exposures (L3)

  Chairperson: Sonja A. Rasmussen, Centers for Disease Control and Prevention
  Speaker: Jan M. Friedman, University of British Columbia
   
9:05 AM–12:30 PM PUBLIC AFFAIRS SYMPOSIUM – Aspen Ballroom
(Joint with DNTS)
  The Toxicology of Tobacco Smoke and E-Cigarette Use during Pregnancy
  Chairpersons: Ludmila Bakhireva, University of New Mexico and John M. Rogers, US Environmental Protection Agency
9:05 AM–9:15 AM   Introduction
     
9:15 AM–9:55 AM S33 Tobacco As a Reproductive and Developmental Toxicant
    John M. Rogers, US Environmental Protection Agency
     
9:55 AM–10:35 AM S34 E-Cigarettes: What are They, What Do They Do, and What Are Potential Impacts on Pregnancy Outcomes?
    Alison Breland, Virginia Commonwealth University
     
10:35 AM–10:50 AM   Break
     
10:50 AM–11:30 AM S35 The Role of Nicotine in the Effects of Maternal Smoking during Pregnancy on Lung Development and Childhood Respiratory Disease
    Virender K. Rehan, University of California, Los Angeles
     
11:30 AM–12:10 PM S36 Neurodevelopmental Toxicity of Tobacco Smoke and Nicotine
    Edward D. Levin, Duke University
     
12:10 PM–12:30 PM   Discussion
   
9:05 AM–12:30 PM GLOBAL BURDEN OF DISEASE: MORTALITY AND SURVIVAL IN INFANTS BORN WITH BIRTH DEFECTS SYMPOSIUM – Colorado Ballroom B
  (Joint with National Birth Defects Prevention Network)
  Chairpersons: Russell Kirby, University of South Florida and Godfrey P. Oakley Jr., Emory University
9:05 AM–9:20 AM S37 Introduction: Why Study Outcomes of Children with Birth Defects?
    Russell Kirby, University of South Florida
     
9:20 AM–9:45 AM S38 Infant and Child Mortality Outcomes for Children with Trisomies
    Russell Kirby, University of South Florida
     
9:45 AM–10:10 AM S39 Perinatal Mortality in the Context of Spina Bifida
    Nelson Pace, University of North Carolina–Chapel Hill
     
10:10 AM–10:35 AM S40 Achieving Reductions in Child Mortality by Preventing Birth Defects in India and Reaching Sustainable Development Goals
    Vijaya Kancherla, Emory University
     
10:35 AM–10:50 AM   Break – Aspen Foyer
     
10:50 AM–11:15 AM S41 Reducing the Global Burden of Disease Associated with Birth Defects
    Robert.J. Berry, Emory University
     
11:15 AM–11:35 AM   Concluding Remarks
    Godfrey P. Oakley Jr., Emory University
     
11:35 AM–12:30 PM   Discussion
   
12:30 PM–2:30 PM LUNCH AND LEARN MINICOURSE – Mt. Columbia
  Epidemiology: Basic Concepts, Study Designs, and Practical Applications
  (Separate Registration Required)
  Organized by the Education Committee, Chairperson, Kimberly C. Brannen, Merck
12:30 PM–1:15 PM Basic Concepts and Methodology
  Peter Langlois, Texas Department of State Health Services
   
1:15 PM–2:00 PM The Significance of Significance Testing and Its Application to the Epidemiology of Rare Outcomes
  Sarah C. Tinker, Centers for Disease Control and Prevention
   
12:30 PM–2:30 PM LUNCH ON YOUR OWN
   
2:30 PM–3:00 PM AGNISH FELLOWSHIP LECTURE – Aspen Ballroom
  Why and How We Must Be Lifelong Educators-Even if It’s Not in Our Job Titles
  Chairperson: Kimberly C. Brannen, Merck
  Lecturer: Elaine Z. Francis, Sandcastle Toxicology Associates
   
3:05 PM–5:30 PM MARIJUANA AND CHILD DEVELOPMENT SYMPOSIUM – Aspen Ballroom
  (Joint with DNTS and OTIS)
  Chairpersons: Diana Dow-Edwards, SUNY/Downstate Medical Center and Susan L. Makris, US Environmental Protection Agency
3:05 PM-3:10 PM   Introduction
    Diana Dow-Edwards, SUNY/Health Science Center
     
3:10 PM-3:35 PM S42 Dynamic Changes in Endocannabinoid Signaling During Adolescence: Implications for Substance Use and Psychopathology
   

BJ Casey, Yale University

     
3:35 PM-4:00 PM S43 Counseling Women About Prenatal Marijuana Use: Weeding through the Data
    Torri D. Metz, University of Colorado-Denver
     
4:00 PM-4:15 PM   Break
     
4:15 PM-4:40 PM S44 Cannabis and the Adolescent Brain: What Does the Evidence Say?
   

Joanna Jacobus, University of California-San Diego

     
4:40 PM-5:05 PM S45

Cannabinoids for Treatment of Pediatric Epilepsy: The Hype and the Evidence

   

Amy R. Brooks-Kayal, University of Colorado-Denver

     
5:05 PM-5:30 PM S46 Cannabis Policy: Challenges and Future Directions
   

Susan R. B. Weiss, National Institute on Drug Abuse

   
3:05 PM–5:30 PM THE USES OF CRISPR/Cas9 TECHNOLOGY WORKSHOP – Colorado Ballroom A
  Chairperson: Alan M. Hoberman, Charles River Laboratories
3:05 PM-3:15 PM   Introduction
    Alan M. Hoberman, Charles River Laboratories
     
3:15 PM-4:00 PM W3 CRISPR-Cas9: From Mechanism to Therapy
    Jacob Corn, University of California-Berkeley
    Learning Objectives: Attendees will learn about advances in next-generation genome editing with applications to the cure of human genetic disease
     
4:00 PM-4:15 PM   Break
     
4:15 PM-5:00 PM W4 The Ethical Implications of CRISPR-Cas9
   

Krishanu Saha, University of Wisconsin-Madison

     
5:00 PM-5:30 PM   Discussion
   
5:30 PM–7:30 PM POSTER SESSION 2 AND EXHIBITS ATTENDED – Capitol Peak Ballroom
 

Teratology Society Posters P15–P43

P15      Zika Related Birth Defect Surveillance in Missouri
Wambuguh L, Garrett L, Sapkota A, McCarthy E. Missouri Department of Health and Senior Services, Bureau of Vital Statistics, Jefferson City, MO, United States.

P16      An Evaluation of the New Zealand White Rabbit Model for Zika Virus Infection during Gestation and Microcephaly in the Offspring
O'Hara MF
1, Ramachandra R2. 1Covance Drug Development, Greenfield, IN, United States, 2Covance Immunology Services, Denver, PA, United States.

P17      Behavioral Screening of the LOPAC1280 Library Reveals that Zebrafish Embryos are Unable to Discriminate Modes of Action for Neuroactive Compounds
Vliet SM1,2, Ho TC2, Volz DC2. 1Environmental Toxicology Graduate Program, University of California–Riverside, Riverside, CA, United States, 2Department of Environmental Sciences, University of California–Riverside, Riverside, CA, United States.

P18      Evaluation of Maternal Transplacental Transfer of Anti-F-Antibodies to Pups Following Immunization of Pregnant Hartley Guinea Pigs with a Recombinant Respiratory Syncytial Virus Vaccine
Murphy CJ, Goodnight SY, Murphy L, Godin CS. Smithers Avanza, Gaithersburg, MD, United States.

P19      Maternal Diabetes Suppresses Mitochondrial Fusion Leading to Heart Defects through the miR-195-Mitofusin 1/Mitofusin 2 Circuit
Zhong J, Yang P. University of Maryland School of Medicine, Baltimore, MD, United States.

P20      The Development of Type 2 Diabetes in Nonobese Male Swiss-Webster Mice: Effect of Exposure to a Gluten-Free Diet
Kepko DS1, Wells C1, Boornazian A2, Gosstola N2, Smith H2, Wing B2, Munagala A2, Thigpen H2, Rasco JF2, Bailey MM1. 1Emporia State University, Emporia, KS, United States, 2University of Alabama, Tuscaloosa, AL, United States.

P21      Survival of Infants with Spina Bifida and the Role of Maternal Pre-Pregnancy Body Mass Index
Pace ND1, Siega-Riz AM1, Olshan AF1, Chescheir NC2, Cole SR1, Desrosier TA1, Tinker SC3, Hoyt AT4, Canfield MA4, Carmichael SL5, Meyer RE6, The National Birth Defects Prevention Study3. 1Department of Epidemiology, University of North Carolina–Chapel Hill, Chapel Hill, NC, United States, 2Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, University of North Carolina–Chapel Hill, Chapel Hill, NC, United States, 3National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States, 4Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TX, United States, 5Department of Pediatrics, Division of Neonatology and Developmental Medicine, Stanford University School of Medicine, Stanford, CA, United States, 6Birth Defects Monitoring Program, North Carolina Department of Health and Human Services, Raleigh, NC, United States.

P22      Computational Toxicology and Computational Modeling of Embryonic Limb Development Using ToxCast High-Throughput Screening Data
Ahir B1, Spencer R2, Baker N2, Judson R3, Martin M3, Knudsen T3. 1University of Illinois College of Medicine at Chicago, Chicago, IL, United States, 2Lockheed Martin, US EPA, Research Triangle Park, NC, United States, 3National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United States.

P23      A 3D Organotypic Human Stem Cell Model to Evaluate Human Palatal Fusion
Wolf CJ, Belair DG, Becker CM, Abbott BD. US Environmental Protection Agency, Research Triangle Park, NC, United States.

P24      Assessment of Developmental Toxicity Potential of Glyphosate-Based Herbicides Using Drosophila melanogaster Primary Embryonic Stem Cell Cultures
Argueta JA, Torres A. California State University–San Bernardino, San Bernardino, CA, United States.

P25      Behavioral Profiling of Zebrafish Embryos Exposed to a Panel of Sixty Water-Soluble Compounds
Ali S1, Champagne D2, Richardson M2. 1Department of Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan, 2Sylvius Laboratory, Institute of Biology, Leiden University, Leiden, The Netherlands.

P26      Teratological Effects of a Panel of Sixty Water-Soluble Toxicants on Zebrafish Development
Ali S
1, Aalders J2, Richardson M2. 1Department of Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan, 2Sylvius Laboratory, Institute of Biology, Leiden University, Leiden, The Netherlands.

P27      Developmental Toxicity of Leucomalachite Green on Zebrafish
Wan H
, Zhang H. Guangdong Zhongke EnHealth Technology Co., Ltd., Foshan, China.

P28      Effect of Neonatal Abstinence Syndrome on Neurodevelopmental Outcomes at Six Months of Age in Infants Born to Women on Medication-Assisted Treatment for Opioid Use Disorder
Ashley M, Holbrook BD, Cano S, Lowe J, Stephen JM, Qeadan F, Leyva Y, Rayburn W, Leeman L, Bakhireva L. University of New Mexico Health Sciences Center, Albuquerque, NM, United States.

P29      Developmental Toxicity of Dimethadione and Acetylsalicylic Acid in Rats
Toy H1, Harris SB2, Mylchreest E1. 1Battelle, West Jefferson, OH, United States, 2Stephen B. Harris Group, San Diego, CA, United States.

P30      Exposure to QACs Alters Inflammatory Responses in Murine Macrophages
Nguyen HD1, McDonald VA2, Hrubec TC1,3. 1E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States, 2Department Biological Sciences, Virginia Tech, Blacksburg, VA, United States, 3VA-MD College of Veterinary Medicine, Blacksburg, VA, United States.

P31      Validation of and Disparities with Prevalence of Congenital Microcephaly: New York State 2013–2015
Fox D1, Brady L1, Pantea C1, Graham K2, Talati A2, Browne M1, Carter S3, Friedenberg E3, Vora N3,4, Lee C3,5. 1Congenital Malformations Registry, New York State Department of Health, Albany, NY, United States, 2Public Health/Preventive Medicine Residency Program, New York City Department of Health and Mental Hygiene, New York City, NY, United States, 3Division of Disease Control, New York City Department of Health and Mental Hygiene, New York City, NY, United States, 4Office of Public Health Preparedness and Response, CDC, New York City, NY, United States, 5Epidemic Intelligence Service, CDC, New York City, NY, United States.

P32      Sex and Dose-Related Differences in Behavior Following Excess Taurine Consumption by B6 Mice during Adolescence and Early Adulthood
Villalona YE, Weimer JL, Massie LA, Marczinski CA, Curran CP. Northern Kentucky University, Highland Heights, KY, United States.

P33      From Inhibition of Retinoic Acid Catabolism to Facial Malformations: Suggestions for a New Adverse Outcome Pathway
Di Renzo F1, Moretto A1,2, Eberini I1, Beronius A3, Zilliacus J3, Hanberg A3, Menegola E1. 1Università degli Studi di Milano, Milan, Italy, 2ICPS ASST Fatebenefratelli Sacco, Milan, Italy, 3Karolinska Instituted, Stockholm, Sweden.

P34      In Vitro Embryo Exposure to Retinoic Acid, Valproic Acid, Ethanol, and to the Antifungal Prochloraz Alone or in Mixture: Effects on Cranio-Facial Morphogenesis
Menegola E1, Bacchetta R1, Battistoni M1, Di Renzo F1, Metruccio F2, Moretto A1,2. 1Università degli Studi di Milano, Milan, Italy, 2ICPS ASST Fatebenefratelli Sacco, Milan, Italy.

P35      Inflammogenic and Vascular Effects of Acute Pulmonary Exposure to Titanium Dioxide Nanoparticles
Abukabda AB
, McBride CR, Nurkiewicz TR. West Virginia University, Morgantown, WV, United States.

P36      Battery of Reproductive Toxicology Studies Supporting the Safety of a Dopamine Receptor Antagonist, Molindone
Krishna G
1, Gopalakrishnan G1, Yu C1, Ganiger S2, White T3. 1Supernus Pharmaceuticals, Inc., Rockville, MD, United States, 2Advinus Therapeutics Ltd., Bengaluru, Karnataka, India, 3Aclairo Pharmaceutical Development Group, Inc., Vienna, VA, United States.

P37      Intersecting Principles of Teratology and Toxicology in Nursing Education and Community Engagement
Dodd-Butera T1, Shaputnic C2. 1California State University, San Bernardino, CA, United States, 2University of California Institute for Fetal Alcohol Spectrum Disorders Discovery, San Diego, CA, United States.

P38      Effects of Quaternary Ammonium Compounds on Neural Stem/Progenitor Cells
Meade HA1, Shea CS2, Hrubec TC2,3. 1Department of Biochemistry, Virginia Tech, Blacksburg, VA, United States, 2E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States, 3VA-MD College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.

P39      Ontogeny of the Central Nervous System across Species
Williams AL1, DeSesso JM1,2. 1Exponent, Inc., Alexandria, VA, United States, 2Georgetown University School of Medicine, Washington, DC, United States.

P40      Alcohol Exacerbates the Teratogenic Effects of Prenatal Cannabinoid Exposure in a C57BL/6J Mouse Model
Fish EW1, Boschen KE1, Murdaugh LB1, Mendoza-Romero HN1, Williams KP2, Parnell SE1. 1University of North Carolina, Chapel Hill, NC, United States, 2North Carolina Central University, Durham, NC, United States.

P41      Evaluation of Ad Libitum Feeding in Pregnant Rabbits
Rayhon SL, Seethala RK, McNerney ME, Thompson KE. Bristol-Myers Squibb Company, New Brunswick, NJ, United States.

P42      Ocular Evaluations in Juvenile Dutch Belted Rabbits
Robinson KJ, Martin AI, Pouliot L, Vezina M. Charles River, Montréal, QC, Canada.

P43      Post Natal Cardiovascular Assessment in Juvenile Beagle Dogs Using Telemetry
Adamo M, Primakova I, Kirouac A, Norton K, Robinson K. Charles River, Montréal, QC, Canada.

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