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(Download PPT-983kb)
- Spring 2000 – Interagency Coordinating Committee established
- October 2000 – Children’s Health Act authorizes NCS
- December 2000 – First Assembly meeting
- October 2001 – Advisory Committee established under FACA
- 2001-2004+ – Working groups (22) focus on hypotheses and measures development
- 2002-2004 – Sample considerations – national probability sample announced June 2004
- Fall 2003 – Expansion of Program Office Staff
- June 2004 – April 2005 – Advisory committee pause for procurement
- November 16, 2004 – Hypotheses, Study plan, Study sites, Coordinating Center RFP, Vanguard Centers RFP
- 2005 – 7 Vanguard Centers and Coordinating Center awarded to pilot the protocol
- 2007 – 17 new Centers and 40 new Locations established for Wave I
- 2008
Funding NCS for $110.9 M
National Academy of Sciences review of Research Plan
39 Wave II Study Centers and Locations awarded
New National NCS website launched
More than 2,500 individuals contributed to the scientific development thus far
- 2009
Vanguard Centers begin participant recruitment for 18- month pilot phase
July – First birth in NCS
Wave I and II deceleration
Administrative Reorganization
Fall – 16 total births
Fall – 43,000 enumeration interviews are finalized
Fall – 21,000 women identified as eligible for pregnancy screener
Fall – 16,500 have completed the screener
Fall – 210 pregnant women have agreed to participate
Fall – All Vanguard Centers participated in staff training events for the P1 visit
The NCS Public Website may be found at: http://www.nationalchildrensstudy.gov/about/Pages/default.aspx
The website is very informative and user friendly. However, you may find the information under the Research tab most relevant to your needs. The following contains brief descriptions of what can be found under this tab.
Hypotheses:
Current NCS (working) hypotheses were developed by multiple teams of scientists and will continue to be refined as the study goes forward. The working hypotheses are grouped into seven categories:
- Pregnancy Outcomes;
- Neurodevelopment & Behavior;
- Child Health & Development; Asthma;
- Obesity & Growth;
- Injury; and
- Reproductive Development.
For downloadable documents containing the specific hypotheses in these areas see:
http://www.nationalchildrensstudy.gov/research/hypotheses/Pages/hypotheses_list.aspx
NCS hypotheses were created in accordance with a federal mandate to “…plan, develop, and implement a prospective cohort study, from birth to adulthood, to… incorporate behavioral, emotional, educational, and contextual consequences to enable a complete assessment of the physical, chemical, biological and psychosocial environmental influences on children’s well-being…”
For a general overview of how the hypotheses were developed see: http://www.nationalchildrensstudy.gov/research/hypotheses/Pages/default.aspx
Adjunct Studies Information:
As the National Children’s Study proceeds, it is anticipated that adjunct studies will be proposed by both internal and external investigators from different sectors (academia, industry, government). Be aware that adjunct studies will probably require outside funding, and will be reviewed via the guidelines found on this page:
http://www.nationalchildrensstudy.gov/research/adjunctstudies/Pages/default.aspx
When examining this resource be sure to note the differences governing the various types of adjunct studies (e.g. Internal Adjunct Studies vs. Outside-Initiated Additions), as well as categories of studies requiring access to more than existing data. Also be aware of the protocols that regulate both timing and data access (see link above).
Research Publications:
A list of relevant publications is available here, via the National NCS website:
http://www.nationalchildrensstudy.gov/research/researchpublications/pages/default.aspx
Reviews & Analytic Reports:
For a selection of relevant white papers that concern (but are not limited to): sampling and design issues, assessing social and emotional development, and mini-monographs on lessons learned from previous longitudinal studies see here:
http://www.nationalchildrensstudy.gov/research/reviewsreports/Pages/default.aspx
Researchers may find these three papers particularly useful:
Final White Paper with Executive Summary: Measurement and Analysis of Exposures to Environmental Pollutants and Biological Agents during the National Children’s Study (November 2004)
And
Lessons Learned from the NIEHS/EPA Centers for Children’s Environmental Health and Disease Prevention Research for the National Children’s Study (October 2005)
And
Final Report: Biomarkers of Environmental Health and Safety Risks to Children for Use in a Longitudinal Cohort Study - Update (August 2004)
Study Design:
***The most detailed (and recent, circa 2007) version of the research plan, available to the public, is available here:***
http://www.nationalchildrensstudy.gov/research/studydesign/researchplan/Pages/Appendices.aspx
This page includes information on background & conceptual frameworks; study designs & methods; study management (adverse events, IMS, Quality Assurance, HIPPA, and Sub/Adjunct studies); and a useful selection of appendixes with information on study centers, biospecimens, environmental measures, and clinical/physical assessments.
For a HISTORICAL version of the continually evolving study plan, from 2004, see here:
http://www.nationalchildrensstudy.gov/research/studydesign/studyplan/Pages/NCS-Study-Plan-2004.pdf
A general overview of the study design – including Hypotheses, Data Collection, Measures & Outcomes, and Results – see here:
http://www.nationalchildrensstudy.gov/research/studydesign/studyplan/Pages/default.aspx
NAS Review of the NCS Research Plan
To read a copy of the National Academy of Science Review of the National Children’s Research plan, May 2008 see: http://www.iom.edu/CMS/12552/45579/58407.aspx
The NCS response to the NAS review may be found at: http://www.nationalchildrensstudy.gov/newsevents/updatesevents/announcements/Pages/ncs_response_NAS_review_082608.pdf
Other documents of interest not accessible on public websites:
- The March of Dimes Review of the National Children’s Study Research Plan Related to Preterm Birth
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