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Annual Meeting 2017

Meeting Program

(Information is subject to change.)

Overview | Friday | Saturday | Sunday | Monday | Tuesday | Wednesday | Thursday

Monday, June 26, 2017
7:00 AM–6:00 PM REGISTRATION OPEN – Aspen Foyer
7:00 AM–6:00 PM SPEAKER READY ROOM OPEN – Crestone Peak
7:00 AM–8:00 AM 2018 PROGRAM COMMITTEE MEETING – Mt. Princeton
(Advance Signup Is Required)

Chairpersons: Dana L. Shuey. Incyte and Dinesh J. Stanislaus, GlaxoSmithKline

(Joint with DNTS)
8:00 AM–9:00 AM KEYNOTE ADDRESS – Aspen Ballroom
(Joint with DNTS)
  Cannabis in Colorado: The Impact of Legalization on Children and Families (L2)
  Chairpersons: Alan M. Hoberman, Charles River Laboratories and Gregg D. Stanwood, Florida State University
  Larry I. Wolk, Colorado Department of Public Health and Environment
  (Joint with DNTS)

Evaluation of Fetal Risk in the Context of Multiple Co-Exposures

  Chairpersons: Ludmila Bakhireva, University of New Mexico and Jeffrey R. Wozniak, University of Minnesota
9:15 AM–9:25 AM   Introduction: Methodological Challenges of Evaluating the Effect of Multiple Exposures
    Ludmila Bakhireva, University of New Mexico
9:25 AM–9:50 AM S16

Defining the Human Exposome

    Cynthia F. Bearer, University of Maryland
9:50 AM–10:15 AM S17 PK/PD Modelling for Multiple Exposures in Pregnancy
    Donald R. Mattison, Risk Sciences International
10:15 AM–10:40 AM   Networking Break – Aspen Foyer
10:40 AM–11:05 AM S18 Alcohol and Nicotine-Induced Epigenetic Changes (miRNAs)
    Rajesh C. Miranda, Texas A&M Health Sciences Center
11:05 AM–11:30 AM S19 Epigenetic Changes Induced by Prenatal Nicotine and Cocaine Exposure
    Pradeep Bhide, Florida State University
11:30 AM–11:35 AM  

Concluding Remarks

    Jeffrey R. Wozniak, University of Minnesota


11:35 AM–12:00 Noon   Panel Discussion
9:05 AM–11:45 AM PLATFORM SESSION 2 – Colorado Ballroom B
  Mechanistic and Clinical Teratology
Chairpersons: John M. DeSesso and Amy L. Williams, Exponent, Inc.

Presenting author is underlined.

9:05 AM-9:15 AM   Introduction
9:15 AM-9:30 AM 11

Prediction of Developmental Toxicity Potential Dictated by In Vivo Exposures with a Biomarker-Based Human Pluripotent Stem Cell Assay
Palmer JA, Smith AM, Colwell MR, Smart BJ, Ludwig MA, Burrier RE, Donley ELR, Kirchner FR. Stemina Biomarker Discovery, Inc., Madison, WI, United States



9:30 AM-9:45 AM 12

DNA Hypermethylation in Tight Junction Pathway Is Associated with Neural Tube Defects: A Genome-Wide DNA Methylation Analysis
Ren A1,2, Wang LL1,2, Lin S1,2, Zhang J1,2, Tian T1,2, Huang Y1,2. 1Institute of Reproductive and Child Health, Peking University, Beijing, China, 2Ministry of Health Key Laboratory of Reproductive Health, Peking University, Beijing, China.

9:45 AM-10:00 AM 13

Toxicogenomic Profiling of BDE-47 Effects in Human Primary Villous Cytotrophoblasts
Robinson JF, Hamilton EG, Ona K, Puckett KA, Kapidzic M, Fisher SJ. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California-San Francisco, San Francisco, CA, United States.

10:00 AM-10:15 AM 14

Targeted Dnmt3a Deletion Ameliorates Maternal Diabetes-Induced DNA Hypermethylation and Neural Tube Defects
Yang P, Xu C, Yang P. University of Maryland School of Medicine, Baltimore, MD, United States.

10:15 AM-10:30 AM 15

VDR Regulates Skeleton Development through MiR-140-5p by Transcriptional Regulation
Luo W, Yang L, Dong Y, Kong J, Yuan Z, Zhao Q. Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.

10:30 AM-10:45 AM   Break—Aspen Foyer
10:45 AM-11:00 AM 16

Biliary Atresia and Maternal Nutrient Intake
Carmichael SL1, Ma C1, Van Zutphen A2,3, Moore CA4, Shaw GM1. 1Division of Neonatology and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, United States, 2Bureau of Environmental and Occupational Epidemiology, New York State Department of Health, Albany, NY, United States, 3Department of Epidemiology and Biostatistics, University at Albany School of Public Health, Rensselaer, NY, United States, 4National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, United States.

11:00 AM-11:15 AM 17

Challenges of Species Selection for Development and Reproductive Toxicity Studies with A Dopamine Agonist
Zhuang Q, Rasmussen AD, Jensen KG, Bernholm K, Northeved H. Nonclinical Safety Research, H. Lundbeck A/S, Copenhagen, Denmark.



11:15 AM-11:30 AM 18

Justifying Mandatory Food Fortification with Folic Acid: Benefits Beyond Preventing Neural Tube Defects
Mills JL. Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, Bethesda, MD, United States.

11:30 AM-11:45 AM 19

An Evaluation of Household Environments and Zika Risk Perceptions, Prevention Behaviors, and Prevention Knowledge among Pregnant Women in Puerto Rico
Turay KR1, Earle-Richardson G1, Medina-Martínez G2, Romero-Pérez M2, Chavez P3, Vega MC5, Thomas D4,5, Rivera-Garcia B5, Prue C1. 1Centers for Disease Control and Prevention, National Center for Emerging and Zoonotic Infectious Diseases, Atlanta, GA, United States, 2Caduceus Staffing, Atlanta, GA, United States, 3Centers for Disease Control and Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Atlanta, GA, United States, 4Centers for Disease Control and Prevention, Office of Public Health Preparedness and Response, Atlanta, GA, United States, 5Puerto Rico Department of Health, San Juan, PR, United States.

12:00 Noon–1:30 PM LUNCH ON YOUR OWN
  (By Invitation Only)
1:30 PM–4:50 PM MARCH OF DIMES SYMPOSIUM – Aspen Ballroom
The Complexities of Caring for the Pregnant and Lactating Patient with Chronic Inflammatory Disease: Maternal and Fetal Considerations
(Joint with OTIS)
  Chairpersons: Christina D. Chambers, University of California-San Diego and Melissa S. Tassinari, Independent Consultant
1:30 PM–1:35 PM   Introduction
1:35 PM–1:55 PM S20 Overview: Complexity of Disease Management in Pregnancy and Lactation, Consequences of Chronic Disease Itself and Polypharmacy, Use of Asthma and Lupus As Examples
    Megan E.B. Clowse, Duke University
1:55 PM–2:15 PM S21 Case Study: Asthma in Pregnancy
    Jennifer A. Namazy, Scripps Clinic Mission Valley
2:15 PM–2:35 PM S22 Case Study: Lupus in Pregnancy
    Megan E.B. Clowse, Duke University
2:35 PM–2:55 PM S23 Missing Data
    Christine Stallman, University of Arizona and MotherToBaby Arizona
2:55 PM–3:15 PM S24 Long Term Effects of Maternal Factors on Child’s Risk for Autism and Other Neurodevelopmental Concerns

Irva Hertz-Picciotto, University of California-Davis

3:15 PM–3:35 PM S25 Chronic Maternal Immune Mediated Diseases and Their Treatments: How Do We Design Good Quality Studies to Evaluate Neurodevelopment in the Offspring?

Gail S. Ross, Cornell University

3:35 PM–3:50 PM   Break - Aspen Foyer
3:50 PM–4:10 PM S26 Lactation and Medications
    Philip O. Anderson, University of California-San Diego
4:10 PM–4:30 PM S27 Pregnancy and Lactation Labeling Rule (PLLR): Placement of Human Data in Labeling

Tamara Johnson, US Food and Drug Administration

4:30 PM–4:50 PM   Panel Discussion
  Chairpersons: Susan Y. Euling, US Environmental Protection Agency and Suzanne E. Fenton, National Institute of Environmental Health Sciences
1:30 PM–2:15 PM S28 Species Differences in Mammary Gland Development and Susceptibility to Environmental Chemicals: Human–Animal Species Comparisons
    Ana M. Soto, Tufts University
2:15 PM–2:55 PM S29 Male Rat Mammary Gland Effects after Developmental Exposure to Environmental Chemicals
    Suzanne E. Fenton, National Institute of Environmental Health Sciences
2:55 PM–3:35 PM S30 Genesis of Male Breast Cancer: An Epidemiologic Perspective
    Louise A. Brinton, Division of Cancer Epidemiology and Genetics, NCI
3:35 PM–3:50 PM   Break – Aspen Foyer
3:50 PM–4:30 PM S31 The Role of Environmental Factors in Pubertal Gynecomastia
    Susan Y. Euling, US Environmental Protection Agency
4:30 PM–5:10 PM S32 The Development of Pubertal Gynecomastia and the Association to Endogenous Hormones, Growth, and Body Composition
    Mikkel G. Mieritz, Rigshospitalet
5:10 PM–5:30 PM   Discussion
5:30 PM–7:30 PM POSTER SESSION 1 AND EXHIBITS ATTENDED – Capitol Peak Ballroom
(Joint with DNTS and OTIS)

Teratology Society Posters P1–P14
DNTS Posters 1-21
OTIS Posters 1–14

P1        Overview of Zika en Embarazadas y Niños en Colombia (ZEN): A Prospective Cohort Study Examining Zika Virus Infection during Pregnancy and Risk of Adverse Pregnancy, Birth, and Infant Outcomes
Colombian Instituto Nacional de Salud1, US Centers for Disease Control and Prevention2, Anderson KN2. 1Colombian Instituto Nacional de Salud, Bogota, Colombia, 2US Centers for Disease Control and Prevention, Atlanta, GA, United States.

P2        Assessing Teratogenicity from the Clustering of Abnormal Phenotypes in Individual Zebrafish Larvae
Ali S2, Aalders J1, Jong T1, Richardson M1. 1Sylvius Laboratory, Institute of Biology, Leiden University, Leiden, The Netherlands, 2Department of Zoology, The University of Azad Jammu and Kashmir, Muzaffarabad, Pakistan.

P3        Quantitative Prediction of Microcephaly Utilizing Cell Agent-Based Modeling: Profiling the Centrosome Cycle
Zurlinden TJ1, Saili KS1, Spencer RS2, Baker NC2, Knudsen TB1. 1National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United States, 2Leidos, Research Triangle Park, NC, United States.

P4        Computational Modeling of the Neurovascular Unit to Predict Microglia Mediated Effects on Blood-Brain Barrier Formation
Zurlinden TJ1, Saili KS1, Spencer RS2, Baker NC2, Knudsen TB1. 1National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United States, 2Leidos, Research Triangle Park, NC, United States.

P5        Cardiovascular Ultrasound of Neonatal Long Evans Rats Exposed Prenatally to Trichloroacetic Acid: Effects on Heart Rate, Ejection Fraction, and Cardiac Output
Narotsky MG1, Thompson LC2, Manley AL3, Ola O4. 1Toxicity Assessment Division, ORD, US Environmental Protection Agency, Research Triangle Park, NC, United States, 2Environmental & Public Health Division, US Environmental Protection Agency, Research Triangle Park, NC, United States, 3Oak Ridge Institute for Science and Education, US Environmental Protection Agency, Research Triangle Park, NC, United States, 4Student Contractor, US Environmental Protection Agency, Research Triangle Park, NC, United States.

P6        Hazard Screening Approaches for Identifying Developmental and Reproductive Toxicity in the Workplace
Pacheco Shubin SE
1, Cohen JM2, Dodge DG3, Lewandowski TA1. 1Gradient, Seattle, WA, United States, 2Gradient, Cambridge, MA, United States, 3Gradient, Bend, OR, United States.

P7        Systems Toxicology Model of Neurovascular Development
Saili KS1, Zurlinden TJ1, Baker NC2, Knudsen TB1. 1National Center for Computational Toxicology, US EPA, Research Triangle Park, NC, United States, 2Leidos, Research Triangle Park, NC, United States.

P8        Orofacial Clefting in Response to Hedghog Pathway Antagonists is Recapitulated in a Practical Epithelial–Mesenchymal 3D Culture Model
Johnson BP2, Vitek RM2, Fink DM1, Chung H1, Geiger P2, Beebe DJ2, Lipinski RJ1. 1University of Wisconsin, Department of Comparative Biosciences, Madison, WI, United States, 2University of Wisconsin, Department of Biomedical Engineering, Madison, WI, United States.

P9        Developmental Neurotoxicity after Exposure to Pesticides: Adding a Biotransformation Component Impacts the Pathways Affected in Human Neural Progenitor Cells (hN2)
McKenzie EM1, Amosu OM1, Smith MA1, Stice SL1,2. 1University of Georgia, Athens, GA, United States, 2ArunA Biomedical, Inc, Athens, GA, United States.

P10      Characterizing the Effect of Embryonic Ethanol Exposure on Cranial Nerve Development in Zebrafish Embryos Mutant for the Ethanol-Sensitive Allele, vangl2
Buckley DM
, Eberhart JK. University of Texas–Austin, Austin, TX, United States.

P11      The Effects of Quaternary Ammonium Compounds on Development of the Microbiome
McDonald VA1, Hrubec TC2. 1Department Biological Sciences, VA Tech, Blacksburg, VA, United States, 2E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States.

P12      Abundance of Household Products Contain Quaternary Ammonium Compounds
Hrubec TC1,2, DiPeppi R1. 1E. Via College of Osteopathic Medicine, VA Campus, Blacksburg, VA, United States, 2VA-MD College of Veterinary Medicine, Blacksburg, VA, United States.

P13      Follow the White Rabbit: Does the Source of Time-Mated New Zealand White Rabbits Impact Maternal or Developmental Parameters?
Olitan TA
, Rayhon SL, McNerney ME, Thompson KE. Bristol-Myers Squibb, New Brunswick, NJ, United States.

P14      A Comparison of the Embryofetal Development Data Collected from New Zealand White (Crl:KBL[NZW]) Rabbits at Several Teratology Laboratories
Pouliot L1, Marsden E2, Lewis EM3, Robinson K1. 1Charles River, Montréal, QC, Canada, 2Charles River, Lyon, France, 3Charles River, Horsham, PA, United States.

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– Mt. Sopris
(Open to Teratology Society, DNTS, and OTIS Student and Postdoctoral Fellows)


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