Program

Meeting Agenda

Teratology Society 2018 Annual Meeting—Mechanisms, Models, Mothers and Babies: Bringing Birth Defects Research into Practice

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Only sessions designated with CME are eligible for Continuing Medical Education credit.

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3:00 PM–6:00 PM


7:30 AM–6:00 PM


8:00 AM–8:30 AM


8:30 AM–12:00 Noon

Organized by the Education Committee, Chairperson, Julia Y. Hui, Celgene Corporation



8:30 AM–8:40 AM


8:40 AM–8:45 AM


8:45 AM–9:30 AM


9:30 AM–10:15 AM


10:15 AM–10:30 AM


10:30 AM–11:15 AM


11:15 AM–12:00 Noon


12:00 Noon–1:30 PM


1:30 PM–5:00 PM

Organized by the Education Committee, Chairperson, Julia Y. Hui, Celgene Corporation



1:30 PM–1:35 PM


1:35 PM–2:20 PM


2:20 PM–3:05 PM


3:05 PM–3:20 PM


3:20 PM–4:05 PM


4:05 PM–4:50 PM


4:50 PM–5:00 PM


5:30 PM–7:30 PM


6:30 PM–9:00 PM


7:30 AM–6:00 PM


7:00 AM–8:00 AM


7:30 AM–8:00 AM


8:00 AM–8:15 AM


8:15 AM–9:00 AM


9:05 AM–12:05 PM



9:05 AM–9:10 AM


9:10 AM–9:30 AM
1


9:30 AM–9:50 AM
2


9:50 AM–10:10 AM
3


10:10 AM–10:30 AM
4


10:30 AM–10:45 AM


10:45 AM–11:05 AM
5


11:05 AM–11:25 AM
6


11:25 AM–11:45 PM
7


11:45 PM–12:05 PM
8


12:05 PM–1:30 PM


12:05 PM–1:30 PM


12:30 PM–1:30 PM


12:30 PM–1:30 PM


1:30 PM–2:00 PM


2:00 PM–2:30 PM


2:35 PM–5:30 PM
CME

Chairpersons: Brian Johnson, University of Wisconsin-Madison and Thomas B. Knudsen,
National Center for Computational Toxicology, US EPA



2:35 PM–2:40 PM


2:40 PM–3:15 PM
S1


3:15 PM–3:45 PM
S2


3:45 PM–4:15 PM
S3


4:15 PM–4:30 PM


4:30 PM–5:00 PM
S4


5:00 PM–5:30 PM
S5


2:35 PM–5:30 PM
CME

Chairpersons: Christina D. Chambers, University of California–San Diego and Lewis B. Holmes, MassGeneral Hospital for Children



2:35 PM–2:55 PM
W1


2:55 PM–3:15 PM
W2


3:15 PM–3:35 PM
W3


3:35 PM–3:55 PM
W4


3:55 PM–4:15 PM
W5


4:15 PM–4:30 PM


4:30 PM–4:50 PM
W6


4:50 PM–5:05 PM
W7


5:05 PM–5:20 PM
W8


5:20 PM–5:30 PM


5:35 PM–6:00 PM


6:00 PM–7:30 PM


P1            An In Vitro Screen of a Panel of Perfluoroalkyl Substances and an In Vivo Assessment of Effects on Placental and Fetal Growth
Blake BE, Cope H, Fenton SE. Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States.

P2            Transcriptomic and Methylomic Profiling of BDE-47 Effects on Human Primary Villous Cytotrophoblasts
Robinson JF1, Williams Puckett KA1,2, Kapidzic M1, Hamilton EG1, Chen H1, Ona K1, Park J-S3, Costello JF4, Fisher SJ1. 1Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of CaliforniaSan Francisco, San Francisco, CA, United States, 2San Francisco State University, Department of Biology, San Francisco, CA, United States, 3Environmental Chemistry Laboratory, Department of Toxic Substances Control, Berkeley, CA, United States, 4Department of Neurological Surgery, University of California–San Francisco, San Francisco, CA, United States.

P3            Characterization of Placental Promoter and Imprint Control Regions (ICRs) Reveals Differentially Methylated Regions across Birthweight Categories
Deyssenroth MA1, Marsit CJ2, Chen J1, Lambertini L1. 1Icahn School of MedicineMount Sinai, New York, NY, United States, 2Emory University Rollins School of Public Health, Atlanta, GA, United States.

P4            Effects of Quaternary Ammonium Compounds on Expression of Placental Growth Factors and Cytokines
Payne SE1, Byrd CE1, Hrubec T1,2. 1Edward via College of Osteopathic Medicine, Virginia Campus, Blacksburg, VA, United States, 2Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.

P5            Concentrations of Selected Heavy Metals in Placental Tissues and Risk of Neonatal Orofacial Clefts
Pi X1, Ren A1, Li Z1, Jjin L1, Wang B1. 1Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University, Haidian, Beijing, China.

P6            Abstract withdrawn.

P7            Prevalence of Maternal Marijuana and Tobacco Co-Use through Umbilical Cord Tissue Analysis
Higginbotham AM, Jones JT. United States Drug Testing Laboratories, Des Plaines, IL, United States.

P8            Smoking during Pregnancy As a Risk Factor for Development and Severity of Neonatal Abstinence Syndrome Severity among Newborns Prenatally Exposed to Opioids
Bailey BA, Wood DL, Justice NA, Shah DS. East Tennessee State University, Johnson City, TN, United States.

P9            Prevalence and Predictors of Opioid Use during Pregnancy over 15 years in the Québec Pregnancy Cohort
Sheehy O1, Berthod C2,3, Bérard A3,4. 1Research Center, CHU Sainte-Justine, Montréal, QC, Canada 2Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada, 3Research Center, CHU Sainte-Justine, Montréal, QC, Canada, 4Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada.

P10         Prevalence and Determinants of ADHD Medication Use in Québec Children between 1998 and 2015
Boukhris T1,2, Lemelin M1,2, Sheehy O2, Bérard A1,2. 1University of Montréal, Montréal, QC, Canada, 2CHU Sainte-Justine Research Center, Montréal, QC, Canada.

P11         Individual Benzodiazepine Exposure during Early Pregnancy and the Risk of Spontaneous Abortion
Zhao J-P1, Sheehy O1, Bérard A1,2. 1Research Center, CHU Sainte-Justine, Montréal, QC, Canada, 2Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada.

P12         Antidepressants Use during Pregnancy and the Risk of Gestational Diabetes Mellitus
Dandjinou M1,2, Sheehy O2, Bérard A1,2. 1Faculty of Pharmacy, University of Montréal, Montréal, QC, Canada, 2CHU Sainte-Justine Research Center, Montréal, QC, Canada.

P13         Countries with an Immediate Potential for Primary Prevention of Spina Bifida and Anencephaly: Mandatory Fortification of Wheat Flour with Folic Acid
Kancherla V. Emory University Rollins School of Public Health, Atlanta, GA, United States.

P14         Considerations for Juvenile Spin-Off from a Nonhuman Primate Enhanced Pre-Postnatal Development Study
York KA1, Chellman GJ2, Newcomb DL2. 1Charles River Laboratories, Reno, NV, United States, 2Charles River Laboratories, Reno, NV, United States.

P15         Oxytocin Priming Facilitates Milk Collection from Long-Tailed Macaques (Macaca fascicularis)
Baker AE1, Edwards J1, Hustvet D1, Ervin T1, Weinbauer GF2. 1Covance Laboratories Inc, Madison, WI, United States, 2Covance Preclinical Services, GmbH, Münster, Germany.

P16         A Qualification/Feasibility Oral Gavage Study in Neonatal Sprague-Dawley Rats and CD-1 Mice
Gordon C, Gueorguieva A, Stoute M, Tavcar R. CiToxLAB North America, Laval, QC, Canada.

P17         Dose Adjustments and Study Designs for Rodent Juvenile Animal Studies
Posobiec LM, Laffan SB. GlaxoSmithKline, King of Prussia, PA, United States.

P18         Juvenile Animal Studies: Suitable Dosing Vehicles and Volumes
Primakova I, Robinson K, Pouliot L. Charles River Laboratories, Montréal, QC, Canada.

P19         Juvenile Development of an Antimalarial in the Hra:(NZW)SPF Rabbit As a Model
Andenmatten N1, Marsh K2, Lewis EM3, Hoberman A3, Mantena R2, Ottinger S4, Tornesi B2. 1Medicines for Malaria Venture, Geneva, Switzerland, 2AbbVie, North Chicago, IL, United States, 3Charles River Laboratories, Inc., Horsham, PA, United States, 4Takeda Development Center, Cambridge, MA, United States.

P20         NTP Developmental and Reproductive Toxicity Evaluation Data Available in CEBS (Chemical Effects in Biological Systems) Database
Fostel J1, Lea IA2. 1Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States, 2ASRC Federal Vistronix, Morrisville, NC, United States.

P21         Applying Systematic Review Methods to Identify and Characterize Health Effects of Diisobutyl Phthalate on the Developing Fetus in Laboratory Animals
Yost EE1, Euling SY2, Weaver JA1, Beverly B1, Keshava N2, Mudipalli A1, Arzuaga X2, Blessinger T2, Dishaw L1, Hotchkiss A1, Makris SL2. 1US Environmental Protection Agency, ORD, National Center for Environmental Assessment, Research Triangle Park, NC, United States, 2US Environmental Protection Agency, ORD, National Center for Environmental Assessment, Washington, DC, United States.

P22         Strategies and Advancements to Evaluate Developmental Neurotoxicity at the National Toxicology Program
Ryan KR1, Hsieh J-H1, Parham F1, Shapiro A1, Sipes N1, Collins B1, Maull E1, Paules RS1, Walker N1, Behl M1. 1Division of the National Toxicology Program, NIEHS, Research Triangle Park, NC, United States.

7:30 PM–8:00 PM


7:00 AM–6:00 PM


7:00 AM–8:00 AM


7:00 AM–8:00 AM


7:00 AM–8:00 AM


7:00 AM–8:00 AM


7:30 AM–8:00 AM


8:00 AM–9:00 AM


9:05 AM–12:00 Noon
CME

Chairpersons: Natalie Johnson, Texas A&M School of Public Health and Peter H. Langlois, Texas Department of State Health Services



9:05 AM–9:10 AM


9:10 AM–9:45 AM
S6


9:45 AM–10:20 AM
S7


10:20 AM–10:35 AM


10:35 AM–11:10 AM
S8


11:10 AM–11:45 AM
S9


11:45 AM–12:00 Noon


9:05 AM–12:00 Noon

Chairperson: Jan M. Friedman, University of British Columbia



9:05 AM–9:30 AM
S10


9:30 AM–10:00 AM
S11


10:00 AM–10:30 AM
S12


10:30 AM–10:45 AM


10:45 AM–11:15 AM
S13


11:15 AM–11:45 AM
S14


11:45 AM–12:00 Noon


9:05 AM–10:15 AM



9:05 AM–9:15 AM


9:15 AM–9:30 AM
9


9:30 AM–9:45 AM
10


9:45 AM–10:00 AM
11


10:00 AM–10:15 AM
12


10:35 AM–12:00 Noon



10:35 AM–10:40 AM


10:40 AM–11:10 AM
W9


11:10 AM–11:40 AM
W10


11:40 AM–12:00 Noon


12:00 Noon–1:30 PM


12:00 Noon–1:30 PM


12:00 Noon–1:30 PM



12:00 Noon–12:10 PM


12:10 PM–12:40 PM
W11


12:40 PM–1:30 PM


1:30 PM–2:00 PM


2:05 PM–5:20 PM
CME

Chairpersons: Evi Struble, US Food and Drug Administration and Susan L. Makris, US Environmental Protection Agency



2:05 PM–2:10 PM


2:10 PM–2:50 PM
S15


2:50 PM–3:30 PM
S16


3:30 PM–3:45 PM


3:45 PM–4:25 PM
S17


4:25 PM–4:45 PM
S18


4:45 PM–5:05 PM
S19


5:05 PM–5:20 PM


2:05 PM–5:20 PM
CME

Chairpersons: Diana Dow-Edwards, SUNY Downstate Medical Center and Grace S. Lee, US Food and Drug Administration



2:05 PM–2:10 PM


2:10 PM–2:45 PM
S20


2:45 PM–3:20 PM
S21


3:20 PM–3:35 PM


3:35 PM–4:10 PM
S22


4:10 PM–4:45 PM
S23


4:45 PM–5:20 PM
S24


2:05 PM–5:20 PM



2:05 PM–2:20 PM


2:20 PM–2:35 PM
13


2:35 PM–2:50 PM
14


2:50 PM–3:05 PM
15


3:05 PM–3:20 PM
16


3:20 PM–3:35 PM


3:35 PM–3:50 PM
17


3:50 PM–4:05 PM
18


4:05 PM–4:20 PM
19


4:20 PM–4:35 PM
20


4:35 PM–4:50 PM
21


4:50 PM–5:05 PM
22


5:05 PM–5:20 PM
23


5:30 PM–7:00 PM


P23         How Reliable are Preliminary EFD Studies for the Detection of Teratogenicity and Embryo-Fetal Toxicity?
Barrow P. Roche Pharmaceutical Research and Early Development, F. Hoffmann-La-Roche Ltd, Basel, Switzerland.

P24         Ensuring Closure: Defining the End of Dosing in Sprague Dawley Rat and New Zealand White Rabbit Embryo-Fetal Development Studies
Rayhon SL, Olitan T, Danberry T, Thompson KE. Bristol-Myers Squibb Company, New Brunswick, NJ, United States.

P25         Syngeneic vs. Allogeneic Pregnancy in Mice: Impact on Implantation?
Danberry T1, Villano C1, McElroy P2, Edwards T2, McNerney M1, Thompson KE1. 1Bristol-Myers Squibb Company, New Brunswick, NJ, United States, 2Charles River Laboratories, Ashland, OH, United States.

P26         Evaluation of Outbred, Syngeneic, and Allogeneic Pregnancy with Sprague Dawley, F344, and Lewis Rat Strains
McGlinchey EM1, Edwards T2, Thompson KE3, Lewis EM1. 1Charles River Laboratories, Inc., Horsham, PA, United States, 2Charles River Laboratories, Inc., Ashland, OH, United States, 3Bristol-Myers Squibb Company, New Brunswick, NJ, United States.

P27         Optimal Method for Revitalization of Overstained and Under-Cleared Rat Fetuses during Teratology Studies
Gilmore R, Flavin J, Dandekar D. Xenometrics LLC, A CiToxLab Group of Companies, Stilwell, KS, United States.

P28         Sensitivity of Micro-Computed Tomography (micro-CT) Imaging versus Alizarin Red Staining in Embryo-Fetal Development Toxicity Studies
Quigley KM1, Tatiparthi AK1, Qualls CD1, Murray KM1, Lewis SL1, Donahue DA1, Staudner HA1, Weinbauer GF2, Groeller AK3, Nesbitt NE3. 1Covance Laboratories Inc., Greenfield, IN, United States, 2Covance Preclinical Services, GmbH, Münster, Germany, 3Covance Laboratories Inc, Greenfield, IN, United States.

P29         Histopathology from Repeat‑Dose Toxicity Studies Is a Poor Predictor of Rat Female Fertility Effects in Retrospective Analysis
Laffan SB1, White T2, Ziejewski MK1, Vidal JD3, Stanislaus DJ1. 1GlaxoSmithKline, King of Prussia, PA, United States, 2Aclairo Pharmaceutical Development Group, Vienna, VA, United States, 3MPI Research, Mattawan, MI, United States.

P30         Rabbit Fertility Studies: Fact or Fiction
Hershberger SL1, Logsdon AL1, Saul JC2, Sellers AC1, Sparks-Smith BL1, White WE1, Staudner HA1. 1Covance Laboratories Inc., Greenfield, IN, United States, 2Covance Laboratories, Ltd, Harrogate, NY, United Kingdom.

P31         Catheterization and Cannulation of the Central Ear Artery of New Zealand White Rabbits for Toxicokinetic Blood Collections
DeVries KE, McKenna M, Veenstra J. MPI Research, Mattawan, MI, United States.

P32         Disruption of Nuclear Receptor Signaling Alters Triphenyl Phosphate-Induced Cardiotoxicity in Zebrafish Embryos
Mitchell CA1, Dasgupta S2, Zhang S3, Stapleton H3, Volz DC2. 1Environmental Toxicology Graduate Program, University of CaliforniaRiverside, Riverside, CA, United States, 2Department of Environmental Sciences, University of CaliforniaRiverside, Riverside, CA, United States, 3Nicholas School of the Environment, Duke University, Durham, NC, United States.

P33         Novel Computational Tools Based on Bioinformatic and Chemoinformatic Data to Complement Zebrafish Embryo Teratogenicity Test
Quevedo C1, Muriana A1, Ipiñazar M1, Planes FJ2, Cendoya X2. 1Biobide, San Sebastian, Gipuzkoa, Spain, 2TECNUN, University of Navarra, San Sebastian, Gipuzkoa, Spain.

P34         Niclosamide Exposure Induces Epiboly Delay during Early-Zebrafish Development
Vliet SM1,2, Dasgupta S2, Volz DC2. 1Environmental Toxicology Graduate Program, University of CaliforniaRiverside, Riverside, CA, United States, 2Department of Environmental Sciences, University of CaliforniaRiverside, Riverside, CA, United States.

P35         Zebrafish Genetic Screens Identify Ethanol Susceptibility Loci Necessary for Palate Development
Lovely CB1,2, Swartz ME2, Eberhart JK2. 1University of Louisville, Louisville, KY, United States, 2University of Texas at Austin, Austin, TX, United States.

P36         Zebrafish Models of FASD: Embryonic Ethanol Exposure Causes Defective Neuronal Migration
Buckley DMM, Eberhart JK. University of TexasAustin, Austin, TX, United States.

P37         Balancing the Maternal Microbiota-Perinatal Neuroimmune Axis: Implications for Neurodevelopmental Disorders
Lebovitz Y1, McDonald V2, Hrubec T2, Theus M3. 1Virginia Polytechnic Institute and State University, Blacksburg, VA, United States, 2Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States, 3Virginia-Maryland College of Veterinary Medicine, Blacksburg, VA, United States.

P38         Does Maternal Exposure to Quaternary Ammonium Compounds Affect Inflammatory Cytokines in the Fetal Mouse Brain?
Byrd CE1, Payne SE1, Hrubec T1,2. 1Edward via College of Osteopathic Medicine, Virginia Campus, Blacksburg, VA, United States, 2Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA, United States.

P39         A Novel Epigenetic Role for the DNA Repair Enzyme Oxoguanine Glycosylase 1 (OGG1) in Neurodevelopment: Ogg1 Knockout (KO) Mice Exhibit Decreased DNA Methylation Levels in a Sex- and Brain Region-Dependent Manner
Bhatia S1, Wells PG2,3. 1Department of Pharmaceutical Sciences and Centre for Pharmaceutical Oncology, Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada, 2Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, ON, Canada, 3Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Toronto, Toronto, ON, Canada.

P40         Dysfunction of Isl1 Positive Cardiac Progenitors Contribute to Maternal Diabetes-Induced Congenital Heart Defects through Cellular Organelle Stress and DNA Hypermethylation
Yang P, Xu C, Yang P. Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Maryland School of Medicine, Baltimore, MD, United States.

P41         Hypomethylation of Genes from Several Signaling Pathways and Neural Tube Defects in Association with Exposure to Polycyclic Aromatic Hydrocarbons
Huang Y, Wang L, Lin S, Jin L, Ren A. Institute of Reproductive and Child Health, Ministry of Health Key Laboratory of Reproductive Health, Peking University, Haidian, Beijing, China.

P42         Alterations in Retinoid Signaling Affect the Development of the Coronary Vasculature
Moise AR1,2,3, Wang S3,4. 1Northern Ontario School of Medicine, Sudbury, ON, Canada, 2Biomolecular Sciences Program and Department of Chemistry and Biochemistry, Laurentian University, Sudbury, ON, Canada, 3Department of Pharmacology and Toxicology, School of Pharmacy, University of Kansas, Lawrence, KS, United States, 4Boston Children's Hospital, Harvard Medical School, Boston, MA, United States.

P43         Gender Differences in the Expression of Nervous System Genes in a Mouse Model of Valproic Acid-Induced Autism-Like Behavior Corrected by S-adenosyl Methionine
Ornoy A1, Weinsteif-Fudim L1, Ergaz Z2, Yanai J1, Turgeman G3. 1Hebrew University Hadassah Medical School, Jerusalem, Israel, 2Haddasah University Medical Center, Jerusalem, Israel 3Ariel University, Ariel, Israel.

P44         Changes in Cyp2b10 Gene Expression during Cyclophosphamide Exposure and Maternal Restraint Stress
McCuistion EA1, Mentzer RW1, Emily M1, Burnett TG1, Hood RD2, Bailey MM1. 1Emporia State University, Department of Biological Sciences, Emporia, KS, United States, 2Ronald D. Hood & Associates, Ponte Vedra, FL, United States.



7:00 PM–9:30 PM


7:00 AM–6:00 PM


7:00 AM–8:00 AM


7:30 AM–8:00 AM


8:00 AM–9:00 AM


9:05 AM–12:00 Noon
CME

Chairpersons: Chris J Stodgell, University of Rochester and Susan L. Makris, US Environmental Protection Agency



9:05 AM–9:10 AM


9:10 AM–9:45 AM
S25


9:45 AM–10:20 AM
S26


10:20 AM–10:35 AM


10:35 AM–11:10 AM
S27


11:10 AM–11:45 AM
S28


11:45 AM–12:00 Noon


9:05 AM–10:20 AM

Chairpersons: Sarah Gloria Običan, University of South Florida and Sonja A. Rasmussen, Centers for Disease Control and Prevention



9:05 AM–9:10 AM


9:10 AM–9:30 AM
S29


9:30 AM–9:50 AM
S30


9:50 AM–10:10 AM
S31


10:10 AM–10:20 AM


10:20 AM–10:35 AM


10:35 AM–12:00 Noon
CME

Chairpersons: Michael D. Collins, University of California–Los Angeles and Grace S. Lee, US Food and Drug Administration



10:35 AM–10:40 AM


10:40 AM–11:20 AM
S32


11:20 AM–11:40 AM
S33


11:40 AM–12:00 Noon
S34


10:35 AM–11:50 AM

Chairpersons: Russell S. Kirby, USF College of Public Health and TBA



10:35 AM–10:50 AM


10:50 AM–11:05 AM
24


11:05 AM–11:20 AM
25


11:20 AM–11:35 AM
26


11:35 AM–11:50 AM
27


12:00 Noon–1:30 PM

Organized by the Education Committee, Chairperson, Julia Y. Hui, Celgene Corporation



12:00 Noon–12:10 PM


12:10 PM–12:50 PM


12:50 PM–1:30 PM


12:00 Noon–1:30 PM


1:30 PM–4:30 PM
CME

Chairpersons: Barbara R. Hales, McGill University and Kembra L. Howdeshell, National Institute of Environmental Health Sciences



1:30 PM–1:45 PM


1:45 PM–2:15 PM
S35


2:15 PM–2:45 PM
S36


2:45 PM–3:15 PM
S37


3:15 PM–3:30 PM


3:30 PM–4:00 PM
S38


4:00 PM–4:30 PM
S39


1:30 PM–4:30 PM

Chairperson: Kenneth Lyons Jones, UCSD, CA MotherToBaby and Elise Madison Lewis, Charles River Laboratories



1:30 PM–1:55 PM


1:55 PM–2:30 PM
S40


2:30 PM–3:05 PM
S41


3:05 PM–3:20 PM


3:20 PM–3:55 PM
S42


3:55 PM–4:30 PM
S43


4:35 PM–6:00 PM


6:00 PM–7:30 PM


P45         Development of a High Throughput-High Content Assay to Identify the Teratogenic Potential of Organophosphates
Garcia J, Ubina TM, Argueta J, Ashour A, Bournias-Vardiabasis N. Department of Biology, California State University San Bernardino, San Bernardino, CA, United States.

P46         A Human Pluripotent Stem Cell-Based Assay Accurately Predicts the Developmental Toxicity Potency for a Series of Valproate Analogues
Palmer JA1, Burrier RE1, Donley E1, Kirchner F1, Kroese D2, Stöber R3, Churchill Kleinstreuer N4. 1Stemina Biomarker Discovery, Inc., Madison, WI, United States, 2TNO, The Hague, South Holland, The Netherlands, 3IfADo– Leibniz Research Centre for Working Environment and Human Factors, Dortmund, North Rhine-Westphalia, Germany, 4NTP Interagency Center for the Evaluation of Alternative Toxicological Methods, NIEHS, Research Triangle Park, NC, United States.

P47         Development of a Stem Cell-Based Reporter Assay for In Vitro DART Assessment
Racz PI, Brandsma I, Derr R, Hendriks G. Toxys BV, Leiden, SH, The Netherlands.

P48         Critical Window of Sensitivity: Teratogenic Effects of Methotrexate Treatment on GD 12 or 14 in New Zealand White Rabbit
Hill KG, Wahle B, Phipps D, Dandekar D. Xenometrics LLC, A CiToxLab Group of Companies, Stilwell, KS, United States.

P49         Developmental Toxicity Study of Polyhexamethylene Guanidine Phosphate in Sprague-Dawley Rats Exposed by Inhalation
Jeong J-S1, Yu W-J1, Lee J1, Lee K-H2, Choi S-J2, Yang M-J2, Lee S-Y1, Park J-D1, Lee S-H2, Bae G-H2. 1Korea Institute of Toxicology, Yuseong, Daejeon, The Republic of Korea, 2Korea Institute of Toxicology, Jeongeup, Jeollabukdo, The Republic of Korea.

P50         Developmental and Reproductive Toxicity Studies in Sprague-Dawley Rats and New Zealand White Rabbits with Palbociclib
Catlin NR1, Bowman CJ1, Engel SM1, Sacaan A2, Lewis EM3, Cappon GD1. 1Pfizer, Groton, CT, United States, 2Pfizer, La Jolla, CA, United States, 3Charles River Laboratories, Inc., Horsham, PA, United States.

P51         Developmental Toxicity Evaluation of Didecyl Dimethyl Ammonium Chloride (DDAC) in the CD® (Sprague-Dawley) Rat and New Zealand White Rabbit
Fisher LC, Burruss BL, Hostetler KA. Toxicology Regulatory Services, A SafeBridge Consultants Company, Charlottesville, VA, United States.

P52         Developmental Toxicity Evaluation of Alkyl Dimethyl Benzyl Ammonium Chloride (ADBAC) in the CD® (Sprague-Dawley) Rat and New Zealand White Rabbit
Fisher LC, Burruss BL, Hostetler KA. Toxicology Regulatory Services, A SafeBridge Consultants Company, Charlottesville, VA, United States.

P53         Two-Generation Reproductive Toxicity Evaluation of Alkyl Dimethyl Benzyl Ammonium Chloride (ADBAC) and Didecyl Dimethyl Ammonium Chloride (DDAC) in CD® (Sprague-Dawley) Rats
Fisher LC, Burruss BL, Hostetler KA. Toxicology Regulatory Services, A SafeBridge Consultants Company, Charlottesville, VA, United States.

P54         Assessment of Chlorodibromomethane Effects on Pregnancy Maintenance in a Developmental Toxicity Screen with F344 Rats
Narotsky MG1, Fuentes L1,2, Willoughby T2,3. 1US Environmental Protection Agency, ORD, National Health and Environmental Effects Research Laboratory, Toxicity Assessment Division, Research Triangle Park, NC, United States, 2Oak Ridge Institute for Science Education (ORISE), Oak Ridge, TN, United States, 3US Environmental Protection Agency, ORD, National Health and Environmental Effects Research Laboratory, Integrated Systems Toxicology Division, Research Triangle Park, NC, United States.

P55         Assessment of Diiodoacetic Acid Effects on Eye Malformations in a Developmental Toxicity Screen with F344 Rats
Fuentes L1,2, Narotsky MG2. 1Oak Ridge Institute for Science Education (ORISE), Oak Ridge, TN, United States, 2US Environmental Protection Agency, ORD, National Health and Environmental Effects Research Laboratory, Toxicity Assessment Division, Research Triangle Park, NC, United States.

P56         SCY-078, a Novel IV/Oral Triterpenoid Antifungal Treatment, Is Not Embryo/Feto-Toxic
Carruthers CM1, Barat S, Thomas P2, Lewis EM2. 1Scynexis, Inc., Jersey City, NJ, United States, 2Charles River Laboratories, Inc., Horsham, PA, United States.

P57         Fetal Toxicity of Cynara scolymus
Gotardo AT, Mattos MIS, Górniak SL. Research Center of Veterinary Toxicology (CEPTOX), Department of Pathology, School of Veterinary Medicine and Animal Science, University of São Paulo, Pirassununga, SP, Brazil.

P58         Investigation of Pre- and Postnatal Developmental Toxicity of Caffeine in Rats
Yang S1, Ding Z2, Lei G1, McPherson S1. 1Wuxi Apptec (Suzhou) Co. Ltd, Suzhou, Wuzhong, China 2WuxiAppTec (Suzhou) Co, Ltd, Suzhou, Wuzhong, China.

P59         Prenatal and Early-Life Exposure to Arsenic: Effects on Tuberculosis Pathogenesis
Rychlik KA1, Sanchez I1, Attreed S1, Sanchez S2, Castriota F2, Zhang H1, Steinmaus CM2, Smith MT2, Sille F1. 1The Johns Hopkins University, Baltimore, MD, United States, 2University of CaliforniaBerkeley, Berkeley, CA, United States.

P60         Does Early-Life Exposure to Estrogenic Chemicals Warrant an Age Dependent Adjustment Factor in Carcinogen Risk Assessments?
Dai M1, Euling SY2, Foos B2. 1Oak Ridge Institute for Science and Education, Office of Children's Health Protection, Washington, DC, United States, 2United States Environmental Protection Agency, Office of Children's Health Protection, Washington, DC, United States.

P61         Evaluation of DART Data Pertaining to Reclassification of Chloroform as a Proposition 65 Reproductive Toxicant
Williams AL1, Bates C1, DeSesso JM1,2. 1Exponent, Inc., Alexandria, VA, United States, 2Georgetown University School of Medicine, Washington, DC, United States.

P62         The Epidemiology of Chloroform Exposure and Developmental Outcomes: A Systematic Review
Pace ND
1, Chang ET2,3. 1Exponent, Inc., Oakland, CA, United States, 2Exponent, Inc., Menlo Park, CA, United States, 3Stanford Cancer Institute, Stanford, CA, United States.

P63         The Influence of Pesticides on Birth Defects and Fetal Development at Broad Spatial Scales
Rumschlag SL, Kirby R, Rohr JR. University of South Florida, Tampa, FL, United States.

P64         An Investigation of Racial-Ethnic Disparities in Location of Delivery, Hospital Transfer, and Survival Among Infants with Congenital Diaphragmatic Hernia
Carmichael SL, Ma C, Shaw GM, Sylvester KG, Hintz SR. Stanford University, Stanford, CA, United States.

P65         Maternal Genitourinary Infections and Risk of Birth Defects in the National Birth Defects Prevention Study
Howley MM1, Feldkamp ML2, Papadopoulos EA1, Fisher SC1, Arnold KE3, Browne ML1,4. 1New York State Department of Health, Albany, NY, United States, 2University of Utah Health Sciences, Salt Lake City, UT, United States, 3Centers for Disease Control and Prevention, Atlanta, GA, United States, 4University at Albany School of Public Health, Albany, NY, United States.

P66         Using Supervised Machine Learning Methods to Develop a List of Medications of Greatest Concern during Pregnancy Using Supervised Machine Learning Methods to Develop a List of Medications of Greatest Concern during Pregnancy
Ailes EC1, Zimmerman J2, Lind JN1, Fan F2, Shi K2, Reefhuis J1, Broussard CS1, Frey MT1, Cragan JD1, Petersen EE3, Polen KD1, Honein MA1, Gilboa SM1. 1National Center on Birth Defects and Developmental Disabilities, CDC, Atlanta, GA, United States, 2Deloitte Consulting LLP, New York, NY, United States, 3National Center for Chronic Disease Prevention and Health Promotion, Atlanta, GA, United States.

P67         National Population-Based Estimates for Selected Birth Defects, 2010–2014
Mai C1, Isenburg J1, Canfield M2, Meyer R3, Alverson C1, Lupo PJ4, Fox D5, Cho SJ6, Correa A7, Kirby R8. 1Centers for Disease Control and Prevention, Atlanta, GA, United States, 2Texas Department of State Health Services, Austin, TX, United States, 3North Carolina Department of Health and Human Services, Raleigh, NC, United States, 4Baylor College of Medicine, Houston, TX, United States, 5New York State Department of Health, Albany, NY, United States, 6Minnesota Department of Health, St. Paul, MN, United States, 7University of Mississippi Medical Center, Jackson, MS, United States, 8University of South Florida, Tampa, FL, United States.

P68         How Does Information about Pregnancy from Social Media Compare to Real-World Data?
Wurst KE, Clayton LM, Powell MS. GlaxoSmithKline, King of Prussia, PA, United States.

P69         A Population-Based Analysis of Factors Associated with Timeliness of Surgical Repair among Infants with Myelomeningocele
Kancherla V1, Ma C2, Grant G2, Shaw GM2, Hintz SR2, Carmichael SL2. 1Emory University Rollins School of Public Health, Atlanta, GA, United States, 2Stanford University, Stanford, CA, United States.

P70         Proportion of Critical Congenital Heart Defects Attributable to Unhealthy Prepregnancy Body Mass Index among Women with Live Births in Florida, 2004–2013
Lowry J1, Lake-Burger H1, Salemi J2, Tanner JP3, Kirby R3. 1Florida Department of Health, Tallahassee, FL, United States, 2Baylor College of Medicine, Houston, TX, United States, 3University of South Florida, Tampa, FL, United States.

P71         Abstract withdrawn.

P72         A Phenotypic Spectrum Overlaps VACTERL and TACRD Associations
Katzman PJ, Patel N, Metlay LA. University of Rochester Medical School, Rochester, NY, United States.

P73         Normal and Abnormal Development of Human Stapes and Its Relation to the Middle Ear Pathologies: A Morphological Approach
Cortés OD, Martinez Burckhartd RJ, López Serna DMN. Facultad de Medicina de la Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico.

P74         California: Pregnancy and Birth Outcomes of Registry-Enrolled Pregnancies Affected by Travel-Associated Zika Virus Infection
Sowunmi S, Eckert V, Griffin A. California Birth Defects Monitoring Program, California Department of Public Health, Richmond, CA, United States.

P75         Density of CD68+ (Hofbauer) Cells in Zika Infected Placentas
Corchuelo S1, Mercado M2, Borbon M1, Rico A3, Parra E3, Ospina M4. 1Gesath, Bogotá, DC, Colombia, 2Dirección de Investigación en Salud Pública, Instituto Nacional de Salud, Bogotá, DC, Colombia, 3Dirección de Redes en Salud Pública, Instituto Nacional de Salud, Bogotá, DC, Colombia, 4Dirección General, Instituto Nacional de Salud, Bogotá, DC, Colombia.

P76         The Use of Metabolomics in the Study of Mild Hypospadias
Pineyro C1, Chorna N2, Perez-Brayfield MR3, Jorge JC1. 1Department of Anatomy and Neurobiology, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, United States, 2Department of Biochemistry, PR-INBRE Metabolomics Research Center, University of Puerto Rico, Medical Sciences Campus, San Juan, PR, United States, 3Division of Urology, School of Medicine, University of Puerto Rico, San Juan, PR, United States.

P77         The Detection of Prenatal Marijuana Exposure using Meconium and Umbilical Cord: A Comparison Using Matched Pairs
Jones MJ1, Jones JT1, Hulen JR1. 1United States Drug Testing Laboratories, Des Plaines, IL, United States.



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Chairpersons: Jan M. Friedman, University of British Columbia and Godfrey P. Oakley Jr., Emory University



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Chairpersons: Katerine Saili, US Environmental Protection Agency and Mary Alice Smith, University of Georgia



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Chairperson: Natasha Catlin, Pfizer, Inc. and Kembra L. Howdeshell, National Institute of Environmental Health Sciences



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